In Brief:
IMPLICATIONS: Isoflurane, at clinically relevant concentrations, inhibits angiotensin II-induced vasoconstriction, but by a mechanism that differs from that of sevoflurane. Unlike sevoflurane, the inhibitory effect of isoflurane on vascular contraction is mainly mediated by an attenuation of the increase in intracellular Ca2+ in response to angiotensin II.
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