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Aorta-Right Atrial Tunnel in an Elderly Patient

Salehi, Ali, MD; Cui, Wilson W., MD, PhD

doi: 10.1213/ANE.0b013e3182a74791
Cardiovascular Anesthesiology: Echo Rounds
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From the Department of Anesthesiology, David Geffen School of Medicine UCLA, Los Angeles, California.

Patient Consent Statement: We have obtained informed consent from the patient for the publication of this report.

Accepted for publication July 11, 2013.

Funding: Not funded.

The authors declare no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site.

Reprints will not be available from the authors.

Address correspondence to Ali Salehi, MD, Department of Anesthesiology, David Geffen School of Medicine UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 3325, Los Angeles, CA 90095-7403. Address e-mail to asalehi@mednet.ucla.edu.

A 71-year-old man with decompensated heart failure due to mitral regurgitation, tricuspid regurgitation, and aortic insufficiency was admitted before his valvular surgery. Preoperative coronary angiography revealed a vessel that was near the right coronary artery (RCA) ostium (Fig. 1). Magnetic resonance imaging showed a tortuous vessel that abutted the RCA anteriorly, coursed posteriorly, and terminated near the pulmonary artery. It was thought to be an arteriovenous fistula originating from the sinus of Valsalva.

Figure 1

Figure 1

Intraoperative transesophageal echocardiography (TEE) confirmed the diagnosis of incompetent mitral, tricuspid, and aortic valves. In addition, in the midesophageal short- and long-axis views of the aortic valve, there was a large vessel exiting from the RCA ostium (Fig. 2A; Video 1, see Supplemental Digital Content 1, http://links.lww.com/AA/A594). The modified bicaval view showed a large continuous jet entering the right atrium (RA) near the superior vena cava (SVC) (Fig. 2B; Video 2, see Supplemental Digital Content 2, http://links.lww.com/AA/A595). The continuous flow was due to the constant pressure gradient between the aortic root and the RA, which differed from the tricuspid regurgitation that only occurred during systole. The proximity of the aortic root and RA suggested a fistula, possibly due to a ruptured sinus of Valsalva aneurysm. However, withdrawing the TEE probe slightly while keeping a short-axis view of the ascending aorta detected color flow Doppler signal in the extra-cardiac space between the aorta and RA (Fig. 3A). Withdrawing further, a tubular structure became apparent (Fig. 3B). After surgical exposure, a vessel was found originating from a dilated ostium that was shared by the RCA. It coursed rightward, before turning posteriorly under the RA appendage and entering the RA near the SVC, consistent with a diagnosis of aorta-right atrial tunnel. The resection of the tunnel, patch closure of its RA opening, mitral and aortic replacement, tricuspid annuloplasty, and reimplantation of RCA were successfully performed on cardiopulmonary bypass.

Figure 2

Figure 2

Figure 3

Figure 3

Aorta-right atrial tunnel is a rare congenital condition. Its incidence is unknown, because most patients are asymptomatic with only a continuous murmur on examination. Symptoms, when present, are usually due to significant left-to-right shunt, pulmonary overcirculation, arrhythmia, and heart failure due to volume overload.1 A review of published reports showed that patients may present at any age, from neonates2 to young adults.1 Our patient was unusual in his advanced age at presentation because there is only 1 previous report of aorta-right atrial tunnel in a septuagenarian.3 Furthermore, in this case, the tunnel was undiagnosed despite a previous transthoracic echocardiogram.

A number of conditions can lead to an abnormal blood return to the RA (Table 1). Coronary-cameral fistula occurs when an aberrant branch of coronary artery drains directly into one of the cardiac chambers causing ischemia and heart failure, usually in utero. Adults with aneurysmal coronary arteries have also been described, either causing external compression of the heart4 or forming a fistula that drains into the RA.5 In our patient, the RCA was of normal caliber and followed a normal course. However, we cannot dismiss the possibility that this was a very proximal fistula originated at the RCA ostium. Also in older patients, a sinus of Valsalva aneurysm and subsequent rupture into the RA is more common than aorta-right atrial tunnel. One institution reported 9 cases of aorta-right atrial tunnel compared with 66 cases of ruptured aneurysm during a 10-year period.1 The key distinction between the 2 is the extra-cardiac location of aorta-right atrial tunnel and its tortuous course. Other causes include trauma, endocarditis, and complications from surgeries involving the aortic valve, ascending aorta, and ventricular and atrial septal defects. A fistula between a saphenous vein graft and RA have also been reported in patients who had coronary bypass surgery.6 One clinical scenario worth mentioning is the Cabrol shunt. For ascending aorta surgeries with difficult hemostasis, the Cabrol shunt is a perigraft space-to-RA conduit used to decompress the perigraft space. This shunt is expected to close spontaneously but may remain open for some time.7

Table 1

Table 1

To our knowledge, this is the first published report of TEE images of aorta-right atrial tunnel. Compared with a transthoracic echocardiogram, TEE is more sensitive due to the probe’s proximity to the relevant structures and freedom to optimize echographic windows with distorted anatomy. While the aorta-right atrial tunnel in our patient originates from the right sinus and is anterior to the aorta, most originate from the left sinus and take a retro-aortic course. We were able to demonstrate the proximal origin of the tunnel from the sinus of Valsalva, its extra-cardiac location, and its termination into the RA near the SVC. Two-dimensional TEE cannot capture its tortuous course in entirety. However, by focusing on the region and using a small adjustment of probe depth and multiplane angles, we were able to capture the tubular tunnel in its short axis. Last, the case highlights that not all left-to-right shunts are necessarily intracardiac, and the continuous Doppler signal suggests the arterial origin of the shunt.

The differential diagnosis of abnormal fistulous connection between the aorta and the RA should include the aorta-right atrial tunnel. Its complex anatomy requires multiple imaging modalities including TEE. Sometimes, as in this case, the distinction between aorta-right atrial tunnel and a coronary artery fistula remains unclear. The need for and timing of surgical intervention of patients with this pathology should be based the severity of symptoms.

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Clinician’s Key Teaching Points

By Nikolaos J. Skubas, MD, FASE, Donald Oxorn, MD, and Martin J. London, MD

  • An extra-cardiac communication between the left (more commonly) or right sinus of Valsalva and the right atrium (RA) is a rare congenital defect known as an aorto-RA tunnel. It usually presents in younger patients with a continuous murmur. Over time, the left-to-right shunt results in pulmonary volume overload. The first echocardiographic sign is often an abnormal color flow signal into the RA.
  • The differential diagnosis of an abnormal color flow signal in the RA includes a congenital fistula between a coronary artery and a cardiac chamber, an iatrogenic communication between the ascending aorta and the RA (as in a Cabrol shunt), and aneurysms of a coronary artery, a saphenous vein bypass graft, or a sinus of Valsalva, all of which may develop fistulous tracts into the RA. In addition, these pathologies may cause extrinsic compression to neighboring structures.
  • In this case of an elderly patient with multiple regurgitant valves, an arteriovenous fistula between the sinus of Valsalva and the RA was diagnosed with angiography. With intraoperative transesophageal echocardiography (TEE), a large tortuous vessel with an anterio-posterior course, abutting the right coronary artery and draining into the RA, was imaged in the midesophageal aortic valve long-axis, short-axis, and bicaval views. Its extra-cardiac course, anterior to the aorta, was verified by slowly withdrawing the TEE probe to the midesophageal ascending aorta short-axis view. Examination with color Doppler imaging revealed continuous, left-to-right flow between the aorta and the RA.
  • The proximity of the TEE probe to the atria may enable the correct diagnosis of rare, abnormal communications between cardiac structures. It may be possible to follow the tortuous course of an abnormal communication by using appropriate multiplane rotation of the transducer and making small adjustments in probe depth. Doppler color flow imaging should be used to determine the direction and duration of the abnormal flow.
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DISCLOSURES

Name: Ali Salehi, MD.

Contribution: This author helped write the manuscript.

Attestation: Ali Salehi approved the final manuscript.

Name: Wilson W. Cui, MD, PhD.

Contribution: This author helped write the manuscript.

Attestation: Wilson W. Cui approved the final manuscript.

This manuscript was handled by: Martin J. London, MD.

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REFERENCES

1. Gajjar T, Voleti C, Matta R, Iyer R, Dash PK, Desai N. Aorta-right atrial tunnel: clinical presentation, diagnostic criteria, and surgical options. J Thorac Cardiovasc Surg. 2005;130:1287–92
2. Tanaka T, Tomita H, Watanabe K, Echigo S. A case of aorto-right atrial tunnel associated with aortic and tricuspid atresia. Pediatr Int. 2005;47:466–8
3. Sung YM, Merchant N. Imaging of congenital aorta-right atrial tunnel with electrocardiogram gated 64-multi-slice computed tomography. Ann Thorac Surg. 2011;92:743
4. Alomar-Melero E, Martin TD, Janelle GM, Peng YG. An unusual giant right coronary artery aneurysm resembles an intracardiac mass. Anesth Analg. 2008;107:1161–2
5. Bittencourt MS, Seltman M, Achenbach S, Rost C, Ropers D. Right coronary artery fistula to the coronary sinus and right atrium associated with giant right coronary enlargement detected by transthoracic echocardiography. Eur J Echocardiogr. 2011;12:E22
6. Balestrini CS, Saaibi JF, Ortiz SN. Aorto-right atrial fistula secondary to rupture of an occluded old saphenous venous graft to right coronary artery. Catheter Cardiovasc Interv. 2013 Feb 13 doi: 10.1002/ccd.24859. [Epub ahead of print]
7. von Knobelsdorff-Brenkenhoff F, Buschmann EE, Pilz B, Schulz-Menger J. Persistent Cabrol shunt causing severe right heart failure. Ann Thorac Surg. 2010;90:312

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