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Target-Controlled Infusions: Paths to Approval

Dryden, Paul E. BS, MBA

doi: 10.1213/ANE.0000000000001018
Anesthetic Pharmacology: Special Article

Target-controlled infusion of IV anesthetic drugs is approved worldwide with the exception of the United States. The purpose of this special article is to review regulatory pathways that could lead to target-controlled infusion (TCI) clearance or approval in the United States.

Published ahead of print October 29, 2015

From ProMedic, Inc., Bonita Springs, Florida.

Accepted for publication August 24, 2015.

Published ahead of print October 29, 2015

Funding: None.

Conflict of Interest: See Disclosures at the end of the article.

Reprints will not be available from the author.

Address correspondence to Paul E. Dryden, BS, MBA, ProMedic, Inc., 24301 Woodsage Dr., Bonita Springs, FL 34134. Address e-mail to

© 2016 International Anesthesia Research Society