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Video Author: Jon Dean & Chris W. Fields Published on: 05.20.2022
Chemogenetic stimulation of basal forebrain cholinergic neurons, via local dialysis delivery of 0.5 mM Compound 21, in sevoflurane-anesthetized female ChAT-Cre rat produced behavioral arousal. Note that the rat is continuously inhaling sevoflurane before, during, and after recovery of the righting reflex. The traces on top of the video show the electroencephalographic activation induced by Compound 21.
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