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General Articles: Special Article

2010 Anesthesia & Analgesia Guide for Authors

2009–2010 Editorial Board, Anesthesia & Analgesia

Author Information
doi: 10.1213/ANE.0b013e3181e6cf7f
  • Free

Summary of Changes to Guide for Authors

  • We have renamed 2 sections.
  • We have added Guidelines for Personal Patient Information.
  • We have modified the article descriptions for Research Reports, Case Reports, and Brief Reports.
  • We have clarified our consent statement requirements.
  • We have added a recommendation to review CONSORT, STROBE, and PRISMA checklists when preparing submissions.
  • We have added text to encourage the use of color figures.
  • We have updated the Academic Misconduct section.
  • We have updated the Expectations of Authors section.


Anesthesia & Analgesia publishes articles that are novel or definitive and improve clinical care or guide future research. This Guide for Authors was written for authors preparing manuscripts for submission to Anesthesia & Analgesia. It explains the Editorial Board's expectations for submitted manuscripts and Journal policies on manuscript handling. The Guide contains extensive information on manuscript preparation that may be helpful regardless of where the authors submit their manuscript.

The Guide for Authors is available at When preparing a manuscript, please be certain to download the most recent version of the guide.

Please contact our Editorial Office for any questions:

  • Anesthesia & Analgesia
  • 100 Pine St.
  • Suite 230
  • San Francisco, CA 94111
  • E-mail:
  • Phone: (415) 777-2750
  • Fax: (415) 777-2803

About Anesthesia & Analgesia

Anesthesia & Analgesia, the oldest publication for the specialty of anesthesiology, is the official scientific journal of the following societies and foundations:

  • International Anesthesia Research Society (IARS)
  • Society of Cardiovascular Anesthesiologists (SCA)
  • Society for Pediatric Anesthesia (SPA)
  • Society for Ambulatory Anesthesia (SAMBA)
  • International Society for Anaesthetic Pharmacology (ISAP)
  • Society for Technology in Anesthesia (STA)
  • Anesthesia Patient Safety Foundation (APSF)
  • American Society of Critical Care Anesthesiologists (ASCCA)
  • Society of Obstetric Anesthesia and Perinatology (SOAP)

Anesthesia & Analgesia is divided into the following sections:

  • Editorials
  • Cardiovascular Anesthesiology, which includes Hemostasis and Transfusion Medicine
  • Pediatric Anesthesiology
  • Pediatric Neuroscience
  • Ambulatory Anesthesiology
  • Anesthetic Pharmacology, which includes Preclinical Pharmacology and Clinical Pharmacology
  • Technology, Computing, and Simulation
  • Patient Safety
  • Economics, Education, and Policy
  • Critical Care, Trauma, and Resuscitation
  • Neuroscience in Anesthesiology and Perioperative Medicine
  • Obstetric Anesthesiology
  • General (otherwise unspecified)
  • Analgesia, consisting of
    • ∘Pain Mechanisms
    • ∘Pain Medicine
    • ∘Regional Anesthesia
  • Cochrane Corner
  • Correspondence
  • Book, Multimedia, and Meeting Reviews
  • The Open Mind

We assign all manuscripts to one of these sections. Most sections have one or more designated Section Editors, responsible for shepherding manuscripts through the peer-review process. Authors may request a journal section at the time of manuscript submission. Requests are considered by the Editor-in-Chief when the manuscript is assigned to a section Editor.

Responsible Conduct of Research

The following pages describe the standards set by the Editorial Board of Anesthesia & Analgesia for responsible conduct of research. The Editorial Board will not consider any manuscript that does not follow these rules.

The name of the research ethical review committee varies with country and local custom. In the United States, the committee is called the IRB. Other countries may use other terms for their research ethical review committee, such as “Research Ethics Committee.” Some institutions refer to the board that reviews animal studies as the “Animal Care and Use Committee.” In this document, “IRB” is used generically to refer to the local board that reviews the ethical treatment of human or animal experimental subjects and grants institutional approval for the study.

Human Subjects

Regardless of the country of origin, all clinical investigators describing human research must abide by the Ethical Principles for Medical Research Involving Human Subjects outlined in the Declaration of Helsinki, and adopted in October 2000 by the World Medical Association. This document can be found at Investigators are encouraged to read and follow the Declaration of Helsinki. Clinical studies not meeting the Declaration of Helsinki criteria will not be considered for publication. If published research is subsequently found to be noncompliant, it will be withdrawn or retracted.

On the basis of the Declaration of Helsinki, Anesthesia & Analgesia requires that all manuscripts reporting clinical research state in the first paragraph of the Methods section that:

  1. The study was approved by the appropriate IRB, and
  2. Written informed consent was obtained from all subjects, a legal surrogate, the parents or legal guardians for minor subjects, or the requirement for written informed consent was waived by the IRB.

Human subjects should not be identifiable. Do not disclose patients' names, initials, hospital numbers, dates of birth, or other protected health care information. Retain copies of your IRB approval and documentation of written informed consent from each study subject. The editor or reviewers may request copies of these documents to address questions about IRB approval and study conduct.

Anesthesia & Analgesia fully supports the Guidelines for Personal Patient Information set forth by Lippincott, Williams & Wilkins (LWW). The LWW guidelines can be downloaded from Key elements of this policy include:

  • Photographs with bars placed over eyes of patients should not be used. If they are submitted, permission from the patient must be documented.
  • Only specific details about the subject that are essential for understanding and interpreting the results of a study, a specific case report, or case series should be provided.
  • Authors and editors should not alter or falsify details in case descriptions to provide anonymity because doing so may introduce false or inaccurate data into the medical literature.
  • Previous publication of patient information or news coverage of a case does not eliminate a patient's right to privacy and does not negate the need for patient consent for use of any patient-identifying information.
  • If “deidentification” is not possible, the editors will ask the author to obtain consent from the patient. If the patient cannot be located or refuses to consent to publication of the identifying information, the manuscript will not be published. Should this situation arise, the corresponding author and the Section Editor should discuss the possibility of deleting the identifying information instead of the entire article before the review process begins.
  • In the event that the patient cannot provide consent because of death or legal incompetency (this includes photos of cadavers), permission from the power of attorney is needed as well as proof of power of attorney.
  • If the patient is a minor, a legal guardian must provide consent.

Investigational Drugs

The Editorial Board of Anesthesia & Analgesia may exercise judgment about the ethics of a clinical trial involving investigational drugs that is more stringent than the investigator's IRB. Compliance with the Journal's guidelines should be specified in the Methods section, when appropriate.

Neuraxial or Perineural Drug Administration

Studies using drugs injected into the neuraxial (caudal, intrathecal, or epidural) or perineural space must meet at least 1 of 3 criteria:

  1. The drug is approved for neuraxial or perineural administration by the United States Food and Drug Administration (FDA) or the equivalent regulatory agency for the country in which the study took place.
  2. The drug is not approved for neuraxial or perineural use, but it is widely used and accepted for neuraxial (e.g., fentanyl) or perineural administration. The publication of dosing guidelines in multiple textbooks represents a reasonable demonstration that a drug is widely used and accepted for neuraxial or perineural administration.
  3. The study is performed under an Investigational New Drug (IND) application approved by the FDA or the equivalent agency in the investigator's country. Investigators in the United States are directed to the FDA website for further information on obtaining an investigator IND. To obtain an investigator IND, the investigator must complete forms 1571 and 1572, which are mailed to the FDA along with the investigator's curriculum vitae. Should the investigator's country not have an equivalent process, the investigator must submit a statement from the IRB that the preclinical toxicity data were reviewed for safety by a qualified expert before approval of the human trial.

Anesthesia & Analgesia will not publish a retrospective paper involving neuraxial or perineural drug administration if the treatment would be considered inappropriate or unethical in a prospective trial.

Drug Studies in Children

Anesthesia & Analgesia is committed to expanding knowledge of the clinical pharmacology of drugs in children. However, studying drugs in children when there is no pediatric indication poses ethical concerns.1 Therefore, studies of drugs in children must meet at least 1 of 3 criteria:

  1. The drug is approved for pediatric administration by the FDA or an equivalent regulatory agency.
  2. The drug is not approved for use in children, but it is widely used and accepted for pediatric administration. A reasonable demonstration that the drug is clinically accepted for use in children is when the administration in the study is consistent with the route, dose, and indication reported in multiple textbooks.
  3. The study is done under an IND application approved by the FDA or the equivalent agency in the investigator's country, as described by Schultheis et al.2 Investigators in the United States are directed to the FDA website for further information on obtaining an investigator IND.

Anesthesia & Analgesia will not publish a retrospective paper involving pediatric drug administration if the treatment would be considered inappropriate or unethical in a prospective trial.

Nonconformity in Dose, Route, or Indication (“Off-label” Use)

In the United States, FDA regulations state that drug use conforms to the package insert (“on-label”) when the dose, route of administration, and indication match the guidelines in the package insert. If the dose, route, or indication does not match the package insert, then the drug use is “off-label.” Drugs are frequently used off-label in clinical trials, and the practice is generally acceptable. However, the Editorial Board of Anesthesia & Analgesia reserves the right to not review a manuscript describing off-label administration of a drug if the Editorial Board believes the study has posed unacceptable risk to the study subjects. To preclude such a determination, investigators are encouraged to obtain an Investigator IND from the FDA or an equivalent agency in their country before initiating studies involving off-label drug administration.

Animal Subjects

Manuscripts that describe investigations performed in vertebrate animals must explicitly state that the study was approved by the authors' IRB for animal research (e.g., the Institutional Animal Care and Use Committee). The Journal expects humane and ethical treatment of all experimental animals and that the study was conducted in a manner that does not inflict unnecessary pain or discomfort upon the animal, as outlined by the United States Public Health Service Policy on Humane Care and Use of Laboratory Animals and the Guide for the Care and Use of Laboratory Animals (1996), prepared by the National Academy of Sciences' Institute for Laboratory Animal Research. This statement should appear at the beginning of the Methods section.

Multiple Publications of Human or Animal Trials

In the interest of minimizing risk to human and animal subjects, as well as promoting efficient use of scarce research funds, investigators may pose several questions and make multiple measurements in a single study, with the intent of publishing multiple manuscripts. This may be a laudable practice, or it may be an inappropriate attempt to slice a single study into “minimum publishable units.” Division of data from a single research study into multiple manuscripts is acceptable, provided the following 3 requirements are met:

  1. The cover letter for every paper derived from the study explains the need for dividing the study into multiple manuscripts. This requirement applies even if only one of the submissions is to Anesthesia & Analgesia. The Journal will consider the appropriateness of the division as part of the review process.
  2. In all manuscripts after the first published manuscript, the investigator must disclose any data that have been reported previously, with appropriate citation to the first manuscript. This practice is essential for scientific continuity. For example, should a question arise about the conduct of the study in one manuscript, readers should be able to identify all manuscripts based on the same experimental data.
  3. Measurements must not interfere with each other. Such interference may happen in ways not evident at the time of the study. For example, measurements of pain thresholds may make it impossible to measure sedative effects. The potential for interfering measurements may not be evident if the pain thresholds and sedation effects are reported in separate manuscripts that are not appropriately cross-referenced.

Registration of Clinical Trials

All clinical trials involving investigational drugs supported by a pharmaceutical firm or investigational devices supported by a device manufacturer must be registered at the time that a manuscript is submitted to Anesthesia & Analgesia for publication. The registry, registration number, principal investigator's name, and date of registration must be stated in the first paragraph of the Methods section of the manuscript. All clinical trials involving investigational drugs or devices supported by a pharmaceutical firm or device manufacturer that began after January 1, 2008 must be registered before patient enrollment. A number of registries have been approved by the International Committee of Medical Journal Editors, including (the most frequently used registry in the United States),,,, and Submissions that have been registered with the European Clinical Trials Database, EudraCT (, meet this requirement.

Conflict of Interest

A conflict of interest exists when an author's judgment about a manuscript may be influenced by secondary gain. Secondary gain typically involves personal, financial, academic, or political advancement. Examples of financial gain are easiest to identify and include direct monetary benefits, such as investments, stocks, and honoraria. When study results (as differentiated from publication per se) may affect an author's bonus, incentive payment (e.g., from likely changes in clinical workload), or salary (e.g., research about academic appointments and salary), this is also considered a conflict of interest. Academic recognition and advancement resulting from publishing high-quality papers are the appropriate reward for good work and do not represent a conflict of interest.

Potential conflicts of interest in addition to actual conflicts of interest also commonly occur and must be considered. In some disciplines, they may be unavoidable. Authors of scientific studies sponsored by industry necessarily possess a conflict of interest. Although this conflict is understood and accepted, it must be disclosed. Investigators frequently also have consulting or lecturing relationships with companies sponsoring their research. These relationships may be entirely appropriate, but must be disclosed.

Conflict of interest disclosure should be made at the time of manuscript submission for each author so that a decision can be made on whether the competing interests may have influenced the manuscript in any manner. Conflicts of interest must be disclosed for every submission, including Editorials and Letters to the Editor.

Conflicts of interest must be disclosed by creating a title page using the online form at The title page generated by this web page must include conflict of interest disclosures for each author. This title page must appear at the beginning of the manuscript.

A manuscript will not be rejected solely because of conflict of interest. However, appearance of a potential conflict of interest could result in a request that the conflict of interest be stated in the published manuscript.

Anesthesia & Analgesia does not have a threshold monetary value to determine “relevant” or “significant” conflicts of interest. Similarly, the Journal believes that there is no specific time beyond which a potential conflict of interest ceases to exist. All relevant potential conflicts of interest should be declared, regardless of monetary value or the date of the relationship. Conversely, we recognize that extensive disclosures of trivial or ancient relationships may unintentionally obfuscate relevant conflicts.

Authors are encouraged to err on the side of full disclosure. Full disclosure at the time of submission has fewer repercussions than subsequent exposure of a real or potential conflict that might have affected the study design, interpretation of data, or another aspect of a study. This does not mean that everything disclosed will appear in the article. Only what is deemed relevant at the time of publication will be included in the published article, based on discussion between the editor(s) and the author(s).

Preparing Your Manuscript

The following pages describe the types of manuscripts published by Anesthesia & Analgesia. The guidelines offer general rules on length, format, and content. These guidelines are intended to help authors write manuscripts meeting the expectations of reviewers and editors, improving chances that a manuscript will be accepted for publication. If a manuscript must deviate from these rules in any significant manner, please contact the Editorial Office in advance of submitting the manuscript to be certain that the Journal will consider publication. Additionally, please explain any significant deviations from the expected format in the “Enter Comments” section when submitting the manuscript using Editorial Manager.

Submissions to Anesthesia & Analgesia should use grammatically accurate English and American spellings. All submissions will be edited for syntax, grammar, and spelling.

Manuscript Types and Word Count

Please review the following descriptions of manuscript types and recommended word counts (also see Table 1). Word counts are for guidance and are not absolute limits. Manuscripts should be as succinct as possible. All accepted submissions must include a title page.

Abstract Requirements

Research Reports describe original clinical or laboratory investigations. A meta-analysis of a series of research papers is also a Research Report. Studies that could be easily predicted as logical extrapolations of existing pharmacology may be rejected without review. For studies of Bispectral Index or other devices, use direct computerized data collection. Research Reports include a structured Abstract (maximum 400 words), Introduction (500 words recommended, e.g., 1 page), Methods, Results, and Discussion (1500 words recommended, e.g., 3 pages). Research Reports typically should be fewer than 3000 words (excluding supplementary online data). Anesthesia & Analgesia currently accepts about 25% of submitted Research Reports.

Case Reports describe “truly exceptional” cases making an important teaching point or scientific observation. They may describe unusual and instructive cases, novel anesthetic techniques, novel use of equipment, or new information on diseases of importance to anesthesiology. The Journal is not interested in “bullet dodged” or “near miss” reports. Case Reports in which nothing happens are not interesting. Case Reports are frequently suitable for documenting unusual cases of toxicity or equipment failure. They are almost never appropriate for describing efficacy of a drug or a treatment, which should be demonstrated by an adequately powered and well-controlled clinical trial. The only exception is a demonstration of efficacy in a population, or a clinical scenario, so uncommon that a clinical trial cannot be performed. Case reports describing successful management of complex cases will only be considered if they make a truly exceptional observation. Case Reports include an unstructured Abstract (maximum of 100 words), Introduction, Case Description, and a Discussion. The Case Description and Discussion typically should be fewer than 1500 words. Case reports about one or more patients must include a statement that the patient, the patient's family, or the local IRB reviewed the case report and gave written permission for the authors to publish the report. If such permission has not been obtained, this must be disclosed in the case report, as well as the reason for not obtaining patient permission. A case report becomes a research study if the authors intend to publish the outcome at the time they are providing treatment for the patient. In this situation, the authors should obtain IRB approval and written informed consent before treating the patient. If that is not possible, the author should obtain IRB approval and patient consent to pursue publication shortly after providing treatment, and in advance of submission to Anesthesia & Analgesia. Interesting but not truly exceptional cases should be submitted as Letters to the Editor. Anesthesia & Analgesia accepts approximately 10% of submitted Case Reports.

Echo Rounds are short reports providing a focused discussion of one or more unique or interesting perioperative echocardiographic images (transesophageal, precordial, epicardial, or epiaortic) from a clinical situation in which echocardiography was central to clinical management. Submissions must provide succinct teaching points on echocardiographic views, techniques, or calculations. Teaching points must be supported by the current literature or standard reference texts of echocardiography, preferably those most accessible to the general reader. Echo Rounds should not be construed as “mini-Case Reports” and as such only the most relevant clinical details should be succinctly presented. The suggested format is to present clinical details and specific echo findings in the first third of the report and didactic discussion of the echo topic(s) in the subsequent two-thirds, followed by no more than 7 references. The report should be accompanied by no more than 3 echocardiographic still images and video clip(s), with legends, which will be available online. The still images should usually, but not always, correspond to the respective video clip(s). Authors should provide appropriate labeling (e.g., arrows and abbreviations of anatomic structures) of figures and clips (if possible) and may elect to consolidate consecutive time segments into one clip (although adequate viewing time for each segment must be provided to clearly illustrate the primary findings being discussed in the text). Selected reports may benefit from the addition of a short table or schematic figure. Authors are advised to examine previously published Echo Rounds (either via the Table of Contents or via the online Echo Rounds database at or via to avoid submission of topics previously published in this series. See page 535 for video formatting details. Echo Rounds do not include an Abstract and should not exceed 800 words in length. Echo Rounds must include a statement that the patient, the patient's family, or the local IRB reviewed the case report and gave written permission for the authors to publish the report. If such permission has not been obtained, this must be disclosed in the text, as well as the reason for not obtaining patient permission. A detailed checklist for submitting Echo Rounds is available at

Echo Didactics are solicited submissions presenting a practical clinical review of a particular echocardiographic topic (e.g., important measurements, specific anatomic evaluation, and current or emerging technologies). Echo Didactics do not include an Abstract and should include a discussion of the relevant background, the “nuts and bolts” of assessment and measurement, and new concepts. Echo Didactics should include 1 to 3 figures or short tables, 1 to 3 video clips (composite videos, as described for Echo Rounds), and appropriate references (not to exceed 10). The author should provide 3 or 4 bulleted teaching points summarizing the most important teaching points. Echo Didactics should not exceed 1000 words.

Brief Reports are intended to report clinical or laboratory research observations. Brief reports are not appropriate for hypothesis-based research, which should be reported as a Research Report. Brief Reports may be appropriate for pilot studies, provided they are limited to the observations and do not formally test a hypothesis. Brief Reports can also be used to provide initial reports of new technologies. Brief Reports require an Abstract, which may be structured or unstructured, depending on the topic (maximum of 100 words). Brief Reports contain an Introduction, Methods, Results, and a very brief (1 paragraph) Discussion. Brief Reports typically should be fewer than 1000 words.

Technical Communications describe instrumentation and analytic techniques. Technical Communications include an unstructured Abstract (maximum of 400 words), and the text of the communication, not exceeding 1500 words.

Review Articles synthesize previously published material into an integrated presentation of our current understanding of a topic. Review Articles should describe aspects of a topic in which scientific consensus exists, as well as aspects that remain controversial and are the subject of ongoing scientific disagreement and research. Review Articles are expected to be comprehensive in scope. If the author used a formal strategy to search the medical literature, this strategy should be described. Review Articles should include an unstructured Abstract of fewer than 400 words. Review Articles typically should be fewer than 5000 words. A meta-analysis is a formal statistical analysis of an existing body of literature, with the intention of producing new knowledge. A meta-analysis should be written and submitted as a Research Report, not as a Review Article.

Medical Intelligence Articles collate and evaluate previously published material to aid in evaluating new concepts or updating old concepts germane to anesthesiology. Medical Intelligence Articles are expected to be highly focused in scope. They should include an unstructured Abstract (maximum of 100 words), and the text of the review, which typically should be fewer than 2000 words.

Special Articles are manuscripts not fitting any of the above categories. They are typically invited by the Editorial Board to examine a particular topic. Occasionally, authors produce publishable scholarly texts not fitting the above models. These may be submitted as Special Articles. There are no word limits or rules for the structure of Special Articles. They may have a structured or unstructured Abstract (maximum of 400 words) or no Abstract.

Editorials provide editorial perspective on articles published in the Journal or express the general policies or opinions of the Editorial Board. They are solicited by the Editorial Board. Editorials do not have Abstracts and typically should be fewer than 1500 words.

Pro/Con Editorials are scholarly discussions of clinically relevant topics providing opposing, well-founded viewpoints. They are solicited by the Editorial Board. Pro/Con Editorials do not have Abstracts and typically should be fewer than 1500 words.

Pro/Con/Core Reviews present a focused review accompanied by expert commentary for and against a specific clinical topic or technique. The Core Review includes an Abstract (unstructured, maximum of 100 words), and the text of the review, which typically should be fewer than 2500 words. It may be accompanied by figures or a video supplement. Pro/Con/Core Reviews are solicited by the Editorial Board.

Book and Multimedia Reviews report current literature in perioperative medicine, critical care, and pain management. Publishers interested in having their book or multimedia material reviewed by the Journal should first contact Dr. Paul White, Section Editor for Book, Multimedia, and Meeting Reviews at or before sending the material. All books and multimedia material for review should be sent to Paul F. White, MD, PhD, The White Mountain Institute, 144 Ashby Lane, Los Altos, CA 94022. Book Reviews typically should be fewer than 750 words.

Meeting Reports are scholarly outlines of the program and content of a scientific meeting. They may be organized temporally (day by day) or thematically (topic by topic). Authors interested in submitting meeting reports should first contact Dr. Paul White, Section Editor for Book, Multimedia, and Meeting Reviews at or to confirm that the meeting is of general interest to the readership. Meeting reports do not have Abstracts and typically should be fewer than 1500 words.

Focused Reviews summarize recent advances in a particular field with direct application to clinical practice. They are intended to efficiently communicate new knowledge to make clinical practice safer, more efficient, and up to date. They are solicited by the Editorial Board. Focused Reviews contain an unstructured Abstract, text, and references. They typically should be fewer than 1500 words.

Commentaries provide expert perspective on articles or topics published in the Journal. They are typically solicited from reviewers who provide unusually thoughtful insight during the peer-review process that should be shared with the Anesthesia & Analgesia readership. They are solicited by the Editorial Board. Commentaries contain only a title page, text, and references and do not have an Abstract. They typically should be fewer than 1500 words.

The Open Mind is a forum for thoughtful, scholarly, and well-referenced reader perspectives. The Open Mind is intended to stimulate discussion. Submissions to The Open Mind must pass the scrutiny of peer review. The Open Mind is not a forum for rants, tirades, or complaints about being overworked and underpaid.3 It is a forum for challenging myths, dogma, and superstition. Submissions to The Open Mind should not have an Abstract and typically should be fewer than 1500 words.

Letters to the Editor

Submit Letters to the Editor using Editorial Manager ( Consider the following points when composing a Letter to the Editor.4


Letters to the Editor about one or more patients must include a statement that the patient, the patient's family, or the local IRB reviewed the case report and gave written permission for the authors to publish the report. If such permission has not been obtained, this must be disclosed in the case report, as well as the reason for not obtaining patient permission. A Letter to the Editor becomes a research study if the authors intend to publish the outcome at the time they are providing treatment for the patient. The authors should obtain IRB approval and written informed consent before treating the patient. If that is not possible, the author should obtain IRB approval and patient consent to pursue publication shortly after providing treatment, and in advance of submission to Anesthesia & Analgesia.


Letters that respond to a published paper typically should be fewer than 300 words. Long critiques are difficult to follow and will likely generate a response that is also too lengthy. Letters describing an interesting or uncommon clinical experience should be limited to relevant clinical details. Unlike Case Reports, these letters should not delve into the background of diseases or therapeutic interventions. A letter describing a new gadget or technique should not exceed several paragraphs. References should be limited to a few key articles.


A letter should address a single issue. It should not discuss an entire subject, but should briefly identify the reason for submission (e.g., a flaw in methodology, relevant observations, or alternative explanation). A letter should be of interest to more than the correspondent and the author of the article in question. Quibbles involving a complex and sophisticated subject or methodology should be settled privately rather than in the Correspondence section of the Journal.

Scientific Accuracy

Letters do not necessarily have the imprimatur of external peer review. Nevertheless, scientific accuracy is crucial. If letters deal with complex or arcane issues, they will be reviewed by members of our Editorial Board or, occasionally, outside reviewers, especially when letters propose a new idea or methodology.


Letters must be respectful. Letters that attack authors, the Journal, or our readership will not be published. Letters that are self-promoting will also not be published. Just as we discourage authors of peer-reviewed articles from claiming to be first to make an observation, we similarly are not interested in letters claiming prior publication of an observation, although we will publish letters to correct the record if we believe that the claim is meritorious.


A letter written in response to a published paper should be submitted no later than 4 months after the paper has been published. A longer interval detracts from the interest, relevance, and impact.


All letters are edited and occasionally completely rewritten, to be highly focused, readable, and succinct. Accepted letters may or may not be forwarded to the author to approve the edited text.

Conflict of Interest

Conflict of interest disclosure is required for all submissions to the journal, including letters.

General Guidelines and Setup Instructions

Authors are encouraged to follow these guidelines carefully, which will improve the timeliness and quality of the review process. The Editors of Anesthesia & Analgesia may return manuscripts to authors without peer review if the manuscripts do not conform to the Journal guidelines.

  • Follow the specifications in Uniform Requirements for Manuscripts Submitted to Biomedical Journals, as updated in 2008, available at
  • Carefully think through the overall organization of your manuscript. Make sure you prepare all parts. Follow the guidance given in the subsections below to prepare each part (see
  • Write clearly. Be straightforward, unambiguous, and succinct, as described in Strunk and White's The Elements of Style.5
  • Follow the technical styles found in these texts:
    • Scientific Style and Format: The CSEManualfor Authors, Editors, and Publishers, 7th ed.6
    • ∘AMA Manual of Style: A Guide for Authors and Editors, 10th ed.7
  • First-time authors will benefit by reading the unpublished “A Step by Step Guide to Writing a Scientific Manuscript” by Wenzel, Dünser, and Lindner, available at
  • Prospective randomized clinical trials should be presented in accordance with the CONSORT statement ( The CONSORT statement includes general principles applicable to many types of investigations. Authors should review the CONSORT checklist when preparing their submission.
  • Prospective and retrospective observational trials should be presented in accordance with the STROBE statement ( Authors should review the appropriate STROBE checklist when preparing their submission.
  • Systematic reviews and meta-analyses should be presented in accordance with the PRISMA statement ( Authors should review the appropriate PRISMA checklist when preparing their submission.
  • Follow these rules when composing your manuscript:
    • ∘Create your manuscript using Microsoft Word or a compatible program.
    • ∘Please use “Standard US Paper” or “Letter” page format (width of 8.5 in. or 21.4 cm, length of 11 in. or 27.7 cm) for your manuscript before uploading the document to Editorial Manager.
    • ∘Double space all text, including references and table and figure legends.
    • ∘Begin each part (title page, abstract, text, acknowledgments, references, tables, and legends) on a new page by inserting a page break before each part.
    • ∘Number pages consecutively beginning with the title page.
  • A Transfer of Copyright form is required only for manuscripts accepted for publication. Please do not send a Transfer of Copyright until you receive a letter of acceptance from the Editorial Office. The form can be downloaded from

The Editorial Office has prepared a series of templates in Microsoft Word format that can be downloaded and used for manuscript preparation. Each template includes the appropriate formatting defaults, instructions for the type of manuscript being submitted, and a checklist for manuscript submission. The instructions and checklist should be deleted before submitting the manuscript electronically. Templates exist for:

Title Page

All submissions require a title page. Please create the title page of your manuscript by going to and completing the form. A complete title page will be generated, which you should paste into your manuscript document (typically a Microsoft Word document) as your title page. You do not need to prepare a separate title page.

The title page generated by the website will contain the following elements:

Title of the Article: Be concise but informative. Include species when appropriate.

Short Title: An abbreviated title of no more than 60 characters, including letters and spaces. The short title appears in the abbreviated table of contents in the journal, and also appears in the footer of the published article.

List of Authors: First name, middle initial, and last name of each author, with highest academic degree(s) and e-mail address, for each author. Each author must:

  • Indicate his or her institution at the time the work was performed. If the author has moved since the work was performed, the current institution may appear in parentheses, e.g., (current affiliation: Columbia University).
  • Disclose his or her role in the manuscript. Identified roles include study design, conduct of the study, data collection, data analysis, and manuscript preparation.
  • Attest to having approved the final manuscript. Additionally, for Research Reports, Brief Reports, and Technical Communications involving more than one author, at least 2 authors must attest to having reviewed the original study data and data analysis. One author must also be designated as the archival author, who is responsible for maintaining the study records.
  • Disclose all conflicts of interest, or indicate that no conflict of interest exists. All relationships between authors and any company or organization with a vested interest in the outcome of the study should be disclosed, including current or previous relationships with a potential interest in the outcome of the research project. More information on conflict of interest can be found on page 528.

Authors must contribute intellectually to the work, as described in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication, updated in 2008 ( Attributing authorship to those who have not contributed intellectually is not acceptable. For example, it is unacceptable to include senior members of a research group, chairs of academic departments, or representatives of the commercial sponsor if they do not meet the requirements for authorship. It is similarly unacceptable to exclude individuals who meet the requirements for authorship. For example, scientists from a sponsoring company who are involved in the study design, execution of the study, data analysis, and preparation of the manuscript should be coauthors of the paper, with appropriate disclosure.

If 2 authors are to be considered “co–first authors,” this should be identified as a footnote to each co–first author. The footnote will appear in the published paper, but does not appear in PubMed.

Name of Department(s) and Institution(s): Name(s) to which the work should be attributed. Multiple institutions may be listed if appropriate. The National Library of Medicine (PubMed) determines institutional affiliation from the affiliation of the first author. Anesthesia & Analgesia has no control over this process.

Corresponding Author: Name, address, telephone number, fax number, and e-mail address of author responsible for manuscript correspondence.

Reprints: Name and address of author to whom requests for reprints should be addressed or a statement that reprints will not be available from the author.

Funding Statement: The source(s) of funding, including foundations, institutions, pharmaceutical and device manufacturers, private companies, or intramural departmental sources.


Location: The Abstract should appear after the title page(s).

Content: Structured Abstracts include Background, Methods, Results, and Conclusions. Structured abstracts should provide enough detail to permit the reader to quickly understand the study and findings.

Background: State the context and purpose of the research, and the hypothesis being tested.

Methods: Define the study subjects or experimental animals, study groups, controls, data collected, primary end points, and analytic and statistical methods.

Results: State the number of subjects studied, key findings, and statistical significance.

Conclusions: State whether or not the hypothesis was proven, and the scientific and clinical conclusions drawn from the study.

Unstructured Abstracts summarize the article, including salient observations and conclusions.

Word Count: Please state the number of words in the abstract after the abstract text.


The text of Research Reports is usually, but not necessarily, divided into the following sections: Introduction, Methods, Results, and Discussion, as described below.


  • Summarize the background in 1 or 2 sentences.
  • Offer only fundamental background information for the work.
  • Succinctly state the purpose of the study.
  • If the study tests specific hypotheses, state the hypotheses.
  • Do not review the topic.
  • The introduction typically should be fewer than 500 words.


  • State the study's conformance with the Journal's requirements for human and animal trials, as described in Responsible Conduct of Research, page 525.
  • If the study involves neuraxial or perineural drug administration, drug administration in children, or “off-label” use of drugs, please state how the study conforms to the Investigational Drugs guidelines on page 526. If the drug is used “off label” and an investigator IND was not obtained, this should be stated. If an investigator IND was obtained, please include the IND number.
  • State the clinical trial registry, registration number, and date of registration if the trial is registered.
  • Inclusion and exclusion criteria: describe how observational or experimental subjects (patients or experimental animals, including controls) were selected.
  • Describe methods, materials, devices (manufacturer's name and city, state, and country location in parentheses), computer software (including revision numbers), and procedures in sufficient detail so that the experiment can be reproduced by other investigators. If the text and the references provide inadequate detail, include an Appendix or other material that would be published as Supplemental Digital Content.
  • Disclose molecular structures when describing novel compounds. Structural disclosure may be waived, at the discretion of the Editorial Board, when there is a compelling reason to publish a manuscript before the sponsor is ready to disclose the molecular structure.
  • Provide references to established methods.
  • Provide references and brief descriptions for published methods that are not well known. The Methods section should be interpretable on its own to a knowledgeable reader, who should not need access to another manuscript to understand yours.
  • Describe new or substantially modified methods, give reasons for using them, and define their limitations.
  • Identify all drugs and chemicals, including generic name(s), dosage(s), and route(s) of administration. Refer to the drugs throughout the text by their generic names, unless the subject of the research is a comparison of branded formulations, in which case the use of the brand name is more precise.
  • Describe all data handling and statistical methods.
  • If you use a methodology that you previously reported, it is acceptable to use wording identical to your previous wording. If you are not the author of the previous description of the methodology, the methodology must be rewritten with reference to the original description of the methodology.
  • Present methodologies in the same order in which the results are presented.


  • The results are the most important part of the manuscript.
  • Present results in logical sequence in the text, tables, and illustrations.
  • Account for all subjects, e.g., number enrolled but not randomized and number withdrawn and for what reasons.
  • Do not repeat large amounts of material in the text that are also presented in tables or figures. However, commenting on key data from tables or figures is necessary to highlight the main findings.
  • Emphasize important observations.
  • In text, tables, and illustrations, present P values as the actual value, rounded to the nearest 100th if greater than 0.01 (e.g., P = 0.04) rather than as an inequality (e.g., P < 0.05). Inequality may be used in footnotes describing symbols that designate statistical significance in tables and figures (e.g., *P < 0.05) and when statistical software uses an inequality to report very small P values (e.g., P < 0.001).
  • Use consistent rules for presenting numerical results. For example, if a numerical result appears in the Abstract, the Results, and a table, be certain that it is reported with the same precision in each instance.
  • In general, determining that the difference between 2 groups is greater than 0 at P < 0.05 is not an interesting result. Even the most trivial difference might be statistically significant if enough subjects were studied. The important questions are: (1) What are the confidence bounds for the difference between groups? and (2) Is the difference large enough to matter scientifically or clinically?


  • Discussions should be focused and succinct.
    • ∘The Discussion should not be a comprehensive review of the literature.
    • ∘The Discussion need not cite every previous study in the field.
    • ∘The Discussion typically should be fewer than 1000 words.
    • ∘The Discussion should not contain inflated claims or product advertisements, e.g., “this new product is conveniently packaged and may transform anesthesia and perioperative medicine.” Claims of being the first to publish a finding are best made in retrospect. Do not claim to be the first to report something. It only invites angry Letters to the Editor.
  • Where possible, structure your Discussion in the same order that the results were presented in the Results section.
  • Emphasize new and important aspects of the study and the conclusions that follow.
  • State the limitations of the study, including the limitations of the materials and methods. State how the limitations temper the conclusions.
  • Succinctly relate the observations to other relevant studies.
  • Do not repeat data presented in the Results section, except as required for clarity.
  • In the last paragraph, link the conclusions with goals of the study. If the study tested a hypothesis, state whether the hypothesis was proven, not proven, or the study was inconclusive.
  • Avoid statements and conclusions that are not completely supported by the data.


  • Use a separate page for each table.
  • Double space each table's entries.
  • Do not submit tables as photographs or pasted images.
  • Tables must be submitted as text in the same manuscript document.
  • Number the tables consecutively. Each table should have a brief title. Each column in a table should have a brief name.
  • Use footnotes (not table titles or column headings) for explanatory matter and definitions of abbreviations. Abbreviations must be described with footnotes, even if they are defined in the text or in other tables.
  • For footnotes, use lower-case italicized letters in alphabetical order.
  • Cite each table in the text in consecutive order.
  • If you include a block of data, a table, or a figure from another source, whether published or unpublished, acknowledge the original source.

Figures and Illustrations

  • For useful information on preparing digital art, please review the detailed instructions at
  • You are encouraged to read The Visual Display of Quantitative Information by Edward Tufte8 at, a superb treatise on statistical graphics, charts, and tables.
  • Design figures and illustrations with their published size in mind, i.e., 1 or 2 columns wide. Large figures will be reduced.
  • Anesthesia & Analgesia publishes in full color, and encourages authors to use color to increase the clarity of figures. Standard colors should be used (black, red, green, blue, cyan, magenta, orange, and gray). Avoid colors that are difficult to see on the printed page (e.g., yellow) or are visually distracting (e.g., pink). Figure backgrounds and plot areas should be white, not gray. Axis lines and ticks should be black and thick enough to clearly frame the image. Axis labels should be large enough to be easily readable, and printed in black.
  • The default formatting provided with Microsoft Excel is not acceptable for scientific graphics. There are numerous programs for creating scientific graphics that are more suitable than Excel (e.g., R, Origin, Prism, SigmaPlot, StatGraphics, and S+). If you decide to use Microsoft Excel to create figures, please use fonts that are clear and appropriately sized for all axis names and labels. In general, sans serif fonts (e.g., Arial or Helvetica) are better for tables than serif fonts.
  • Number figures consecutively. Supply a brief title for each. Cite figures in the text in consecutive, numerical order.
  • If a figure has already been published, acknowledge the original source. You must obtain and submit written permission from the copyright holder to reproduce the material when you submit the manuscript for review. Unpublished figures require permission of the author. Permission is required to reproduce any previously published material except for documents or figures in the public domain.
  • Define all abbreviations used in each figure. Repeat definitions of any abbreviations used in subsequent legends.


  • All references must be generally available to readers. Cite references to articles only if they are published in peer-reviewed journals included in the Index Medicus. Unacceptable references include abstracts appearing only in meeting programs or abstracts more than 3 years old. These should be listed as footnotes. Number references consecutively in the order in which they are first mentioned in the text. Double space between all lines of each reference and between references.
  • Cite references in text, tables, and legends using superscripted numbers after the punctuation in the order in which the citations appear in the text, tables, and figure legends (e.g., Wong et al.1 described …).
  • The titles of journals must be abbreviated according to the style used in Index Medicus.
  • Verify all references against the original documents or Medline (
  • Submit copies of “in press” references to Editorial Manager when the manuscript is submitted.
  • Check the citation list for duplicate entries.
  • Use the formats of the example references shown in Table 2 as guides for formatting references.
Table 1
Table 1:
Reference Formats

Supplemental Digital Content

Supplemental digital content provides additional material too detailed for inclusion in the manuscript or material not readily presented in printed form. For example, supplemental digital content may include audio and video files, spreadsheets, additional figures and tables, appendices, data files, and statistical analysis programming code. If supplemental digital content is submitted, be sure to remove all patient identifiers from the material.

Supplemental digital content should be labeled as to whether they are to be published in the print journal or as an online supplement, or not published and are for reviewers only. Please also cite the supplemental digital content in the text along with a very brief description, for example, “Supplemental Video 1, dilated right coronary artery….”

Because supplemental digital content is part of the overall submitted manuscript, make every effort to have the supplement clearly formatted and organized. More detailed instructions can be found online at

Authors are urged to share raw data whenever possible. Raw data are invaluable to the community of investigators working to move a discipline forward. Excel spreadsheets are frequently used to share raw data. If authors are not comfortable sharing data online as supplemental digital content, they should indicate as a footnote on the title page which author (if any) can be contacted via e-mail for the raw data. All data shared as a web supplement should be appropriately deidentified to protect patient privacy.


Please follow the guidelines below for submitting supplemental video (including video for Echo Rounds and Echo Didactics) and audio files:

  • The preferred video file formats are MPEG-4 (MP4), QuickTime (MOV), and Windows Media Video (WMV). Please preview video clips on both Windows and Macintosh platforms to be certain they play correctly. The review process will be delayed if the Editorial Office cannot play the video clip.
  • Deliver still images from video clips in high-resolution JPEG or TIFF formats.
  • Individual video clips should not exceed 10 MB.
  • Use video-compression software to reduce video size if necessary. Optimal video frame dimensions are 480 × 360 pixels and 640 × 480 pixels. Videos of 320 × 240 pixels have inadequate resolution for teaching purposes. Video clips are typically 15 to 25 seconds.
  • Combinations of clips: If several video clips are combined, for example, several transesophageal echocardiographic loops, please provide adequate time for each segment and leave a suitable gap between the videos. Use appropriate labeling to ensure that the viewer can understand the timing of the pathology and events. Labeling can be added with video editing programs, such as Adobe Premiere or iMovie.
  • Patient Identifiers: Remove all patient identifiers including the date of the study from video clips and still images.
  • For echocardiographic video, please consult Masking Personal Health Information on Real-time Echocardiographic Images by Rokey and Vick.9


  • Submit audio files in WAV or MP3 formats.

Units of Measurement

Anesthesia & Analgesia serves an international audience. For this reason, Système International (SI) units are preferred.

We recognize that authors and readers unfamiliar with SI units have difficulty interpreting them. Authors may make undetected errors if they convert their measurements to SI units. To minimize the chance of conversion errors, authors should submit manuscripts using the units of measurement used in the study, or the units that are used clinically at the author's institution. These are the units that will appear in the published manuscript.

Readers may readily convert published units to units of their choice using commonly available conversion tables. Anesthesia & Analgesia provides a spreadsheet for unit conversion, available at http://www.aaeditor/units.xls.

A more complete conversion table can be found in the AMAManual of Style : A Guide for Authors and Editors, Chapter 15: Units of Measure, Table 4: Conversions from Conventional Units to Système International (SI) Units, pp 486 to 503.10


AAWP: Avoid Abbreviations Whenever Possible. The added length of spelling out words is more than compensated for by the increased readability of your manuscript when words are spelled out.

Idiosyncratic abbreviations make text particularly difficult to read. Abbreviations widely used within a narrow discipline can make a manuscript uninterpretable to the interested reader from outside that discipline.

Do not create new or unusual abbreviations. For example, if the paper refers to the paw pressure test, just call it the paw pressure test throughout the paper, not the PPT.

When it is necessary to use an abbreviation, at the first mention of an abbreviated term in the abstract, text, each figure legend, and each table, spell out in full and follow immediately with the abbreviation (enclosed within parentheses). For subsequent uses of the term in the same section, use only the abbreviation, without parentheses. Some authors use abbreviations to decrease the word count of a manuscript. Please don't do this. Clarity is more important than brevity. In general, if a term is used fewer than 5 times, an abbreviation is probably unnecessary.

Write as you speak. An electrocardiogram might be called an ECG, or EKG, so it is acceptable to abbreviate it as ECG or EKG (after it is spelled out on first use). However, spell out words if there is any possible ambiguity. This will help clarify the manuscript on morphine sulfate kinetics in multiple sclerosis patients with severe mitral stenosis undergoing maxillary sinus surgery analyzed with Microsoft Excel.

Consult the following sources for abbreviations:

Submitting the Manuscript

  1. Go to Editorial Manager at, or access the same site from either or, where the link can be found under “For Authors.”
  2. If you have not previously submitted a manuscript to Anesthesia & Analgesia or had one reviewed for the Journal, you must click “Register” to create a username and password and create an account. Otherwise, just log in with your username and password.

What Happens After Submission?

Manuscripts are reviewed by the Editorial Office to make certain that the submission contains all parts and is properly formatted. The Editorial Office will not forward manuscripts to the Editor-in-Chief if the manuscript is not complete. An e-mail will be sent to the author describing how to finalize the manuscript.

Manuscripts are then forwarded to the Editor-in-Chief, who makes an initial assessment of the manuscript. If the manuscript does not appear meritorious, or is not appropriate for Anesthesia & Analgesia, the manuscript will be returned with an explanation that it has not been forwarded for external peer review.

If the manuscript appears meritorious and appropriate for the Journal, the Editor-in-Chief assigns the manuscript to the appropriate Section Editor, or serves as Section Editor if the manuscript falls within the “General” section of the Journal. Authors are encouraged to suggest the section of the Journal they believe is best suited for their manuscript. The Editor-in-Chief considers authors' suggestions when assigning a manuscript to a section within Anesthesia & Analgesia.

The Section Editor makes an initial assessment of the manuscript. The Section Editor determines whether the manuscript is meritorious and verifies that the assignment of the manuscript to his or her section is appropriate. If the manuscript meets these criteria, it is sent for peer review.

Authors may recommend specific reviewers, or request that their work not be assessed by specific reviewers. These recommendations are considered when assigning reviewers, but the handling editor may choose to not follow these recommendations.

Acceptance of manuscripts is based on the importance of the findings, originality, and scientific rigor. Reviewers submit their critiques of the manuscript to the Section Editor, using Editorial Manager. The Section Editor drafts an initial decision letter, weighing the views of the reviewers and his or her own impressions of the manuscript. This decision letter is forwarded to the Editor-in-Chief, who may modify the decision. The decision letter is then forwarded to the Editorial Office for final editing and then sent to the author by e-mail.

Anesthesia & Analgesia currently accepts about one-quarter of the manuscripts submitted, making it among the most selective journals in the specialty. If a manuscript is rejected and the author believes that the reviewers' critiques can be addressed, the author may appeal the rejection by sending a letter to editor@ If the author chooses to submit the paper elsewhere, we strongly encourage the author to first revise the manuscript, based on the reviews received from Anesthesia & Analgesia, to have the best chance of publication elsewhere. Rejected manuscripts resubmitted without permission will be rejected without further review.

Sometimes we recommend that a rejected manuscript or Case Report be resubmitted to Anesthesia & Analgesia as a Letter to the Editor. This occurs when the manuscript is not exceptional enough for publication, but contains an interesting observation that our readers would value. If the manuscript or Case Report is rejected, with a recommendation to resubmit as a Letter to the Editor, the manuscript or Case Report must be revised to meet the guidelines for Letters to the Editor. Additionally, the Correspondence Editor is under no obligation to accept a Letter to the Editor submitted at the suggestion of a Section Editor. The letter will be evaluated on its own merits.

Authors can expect an initial decision on submitted manuscripts or letters within 6 weeks. Nearly all accepted manuscripts undergo several rounds of revision and copyediting to produce the best possible published paper.

Once the Section Editor decides that a manuscript is ready for publication, a provisional acceptance letter is forwarded to the Editor-in-Chief. If the Editor-in-Chief accepts the recommendation, your manuscript is accepted and you will receive an e-mail. The manuscript is then reviewed by the Editorial Office for proper English and clear writing. The Editorial Office may return the manuscript to the Section Editor or Editor-in-Chief if portions are incomprehensible, or may contact authors for clarifications about unclear text or references. Once the Editorial Office prepares your manuscript to conform with journal style, the manuscript will be forwarded to the publisher.

The publisher further edits the manuscript and prepares a “galley proof” of the typeset manuscript. You will receive this from the publisher by e-mail link. It is essential that you carefully review your galley proof, including the spelling of the names and affiliations of every author. Failure to return the galley proof may prevent publication. Manuscripts are in the publication queue when the galley proof is created, so please review your galley proof within 2 working days to ensure that any corrections are caught before the Journal is printed. Errors in printed manuscripts are almost always present in the galley proof, and would have been caught before publication if the author had carefully reviewed the galley proof. The galley proof will also include “author queries,” which must be answered.

The usual time from acceptance to publication is 4 to 6 months. This can be as short as 2 months for very brief communications, and as long as 1 year for manuscripts included in a collection of related papers.

Academic Misconduct

Anesthesia & Analgesia is a member of the Committee on Publications Ethics (COPE) Code of Conduct for Editors of Biomedical Journals, and adheres to COPE's Good Publication Practice (see

The U.S. Public Health Service's Office of Research Integrity has devoted a considerable amount of effort to help institutions and authors understand responsible conduct of research. We strongly recommend that authors utilize this excellent resource, available at

We will limit our discussion to just 3 areas of academic misconduct: plagiarism, duplicate publication, and data falsification. Plagiarism is the use of previously published material without attribution. There is an excellent summary of what constitutes plagiarism at∼wts/pamphlets/plagiarism.shtml. The ability to rapidly search text fragments using Google and similar search tools on the Internet makes plagiarism very easy to identify.

Self-plagiarism is the use of your own previously published material without attribution. This is a common practice when a laboratory frequently uses the same methodology. In this setting, the description of an assay or an analysis technique may be identical in multiple papers. This is acceptable. However, with this sole exception, manuscripts that plagiarize previously published material, even if it is the author's own work, will be rejected if identified during peer review and will be retracted if the plagiarism is discovered after publication.

Authors uncomfortable with writing in English occasionally use sentences from a published manuscript simply to obtain grammatically correct text. This is still plagiarism. This is generally discovered during the review process and will result in rejection of the submission and possible sanction. Authors uncomfortable with writing in English are strongly encouraged to ask for editing help from colleagues proficient with scientific English. Duplicate publication is prior publication of a manuscript with considerable content overlap by the same author or coauthors. Prior publication may be in the same language, or it may be a translation (usually to English from the author's native language). If a manuscript has been published previously, the submission to Anesthesia & Analgesia will be rejected, unless it has already been published, in which case it will be retracted. Anesthesia & Analgesia uses the CrossCheck program ( to identify plagiarism. CrossCheck compares the manuscript text to both published manuscripts and text downloaded from websites.

Prior publication of an abstract does not count as duplicate publication. We request that authors inform the Journal when parts of a manuscript have previously been published as an abstract.

There is sometimes value in publishing in English an important manuscript previously published in another language. Anesthesia & Analgesia will consider such submissions. However, they must be accompanied by a letter from the copyright holder of the original publication granting Anesthesia & Analgesia permission to publish the work. Duplicate submission is concurrent submission of a nearly identical manuscript to 2 journals. Duplicate submissions identified during peer review will be immediately rejected. Duplicate submissions that are discovered after publication will be retracted. Data falsification is any manipulation of data that is not disclosed in the publication. This can include editing data (removing outliers, altering values), creating false data, or misrepresenting data analysis (e.g., describing an intent-to-treat analysis but actually performing a per-protocol analysis). Any manuscript in which the data have been falsified will be rejected if the falsification is discovered during peer review. If the manuscript has been published, it will be retracted.

Anesthesia & Analgesia reviews all allegations of academic misconduct. This review includes inquiries to the author for clarification. If inquiries to the author do not generate satisfactory replies, we will request that the author's institution assess the facts. Anesthesia & Analgesia will cooperate fully with any institutional inquiry into allegations of academic misconduct and will provide the inquiry board with copies of all submissions and correspondence. The conclusion of the author's institution is not binding on Anesthesia & Analgesia.

Sanctions against authors range from requesting a Letter to the Editor acknowledging the error and voluntarily withdrawing a manuscript, to a lifetime ban on publication in Anesthesia & Analgesia.

Expectations of Authors

The Journal has an overriding interest in research integrity. To fulfill this obligation, all authors must fulfill the following expectations:

  1. All authors must attest to having reviewed and approved the final manuscript.
  2. For Research Reports, Brief Reports, and Technical Communications a single author must be designated as the archival author. The archival author is responsible for maintaining the study records, and will be contacted should questions about the data arise after publication.
  3. For Research Reports, Brief Reports, and Technical Communications with more than 1 author, at least 2 authors must attest to
    1. Having seen the original study data.
    2. Having reviewed the data analysis.
  4. Authors are expected to participate in any external review that assesses the integrity of their research. Failure to fully cooperate with any inquiry into the integrity of their research may result in retraction of any papers related to the research by Anesthesia & Analgesia.
  5. Authors should be prepared to make original research records, informed consents, IRB approvals, spreadsheets, and analyses available for review by the Journal should questions arise during or after the peer-review process about the integrity of the data or the ethical conduct of the research. The Journal acknowledges that authors may need to redact protected health care and proprietary business information from research records to protect patient and organizational confidentiality. Anesthesia & Analgesia recognizes that authors may have legitimate reasons for not providing raw data to the Journal. If such data are not provided, the Journal may elect to not consider the manuscript. After publication, the Journal encourages authors to make data freely available to other investigators. The Journal acknowledges that the decision to share data rests with the authors, and that there are legitimate reasons for authors declining such requests.
  6. Authors understand that the Journal may make available to an author's institution any communications between the author and the Journal if requested to do so by a review panel investigating possible academic misconduct under the auspices of the institution.
  7. Authors understand that journal editors may share information about academic misconduct with the editors of other journals, as misconduct frequently involves more than a single journal.

Copyright and Retained Rights

Copyright Assignment Agreement

Once a manuscript is accepted for publication, we require all authors to sign a copyright assignment agreement. This agreement covers all submitted written material and supplementary digital content and assigns the copyright to the International Anesthesia Research Society, owner of Anesthesia & Analgesia. If excerpts from copyrighted works are included in the submitted material, authors must obtain a written release before submission and provide credit to the original publication.

In the case of material that has been written as part of the duties of an employee, an authorized representative of the employer must also sign. If the submitted material or a portion of it has been created in the course of any author's employment by the United States Government, it is called a “work of the U.S. Government” and is not subject to copyright.


Upon acceptance of the article for publication, each author must remove any prior versions of this work (normally a preprint) that may have been posted to an electronic server.

Retained Rights, Institutional Postings

Except for copyright, other proprietary rights related to the submitted material (such as patent or other rights to any process or procedure, or reuse of the material for the personal noncommercial benefit of the author) are retained by the authors. Anesthesia & Analgesia will permit the author to deposit for display a “postprint” (the final manuscript after peer review and acceptance for publication but before the publisher's copyediting, design, formatting, and other services) 12 months after publication of the final article on his/her personal website, university's institutional repository, or employer's intranet.

Compliance with National Institutes of Health (NIH) and other research funding agency accessibility requirements: A number of research funding agencies now require or request authors to submit the postprint to a repository that is accessible online by all without charge. As a service to our authors, based on your indication of funding on the copyright assignment agreement, the Journal will identify articles that require deposit and transmit the postprint of the articles to the NIH Manuscript Submission System (NIHMS). Upon NIHMS request to the author, it remains the legal responsibility of the author(s) to validate the submission with the repository.

Fair Use

Authors can republish portions of their accepted manuscript, for personal noncommercial purposes, at their discretion. When this occurs, we ask that the article be attributed as published in the Journal. If an author wishes to reproduce an article in its entirety, exactly as published in the Journal, permission should be obtained through the “Request Permission” link to the article on the journal's online website.


Anesthesia & Analgesia exists for the benefit of current and future patients under the care of health care professionals engaged in the disciplines broadly related to anesthesiology: perioperative medicine, critical care, and pain management. The Journal furthers the care of these patients by reporting the fundamental advances in the sciences of these clinical disciplines and by documenting the clinical, administrative, and educational advances that guide therapy. The Journal thus seeks a balance between outstanding basic scientific reports and definitive clinical and management investigations. The Journal welcomes original manuscripts reflecting rigorous analysis, even if unusual in style and focus.

Anesthesia & Analgesia accepts a limited number of the manuscripts submitted for publication. However, the Journal is genuinely honored by every submission. In exchange for authors' following the Guide for Authors, the Journal promises to consider every manuscript thoughtfully. In addition, the Journal promises to treat all authors with the respect and dignity they have so thoroughly earned by their dedication to improving the health and well-being of patients.


Many members of the Editorial Board of Anesthesia & Analgesia also serve on the editorial boards of other journals. Anesthesia & Analgesia acknowledges the contribution of these editorial boards to these guidelines through our overlapping editors. Neither Anesthesia & Analgesia nor the International Anesthesia Research Society (IARS) wishes to claim ownership of the principles espoused in these guidelines. The IARS hereby grants societies, journals, and individuals the right to paraphrase or quote verbatim sections of any length from these guidelines without attribution.

† U.S. Food and Drug Administration: Information for Sponsor-Investigators Submitting Investigational New Drug Applications (INDs). Available at: Accessed April 9, 2010.
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10. American Medical Association. Manual of Style: A Guide for Authors and Editors. 9th ed.Baltimore: Williams & Wilkins, 1998
© 2010 International Anesthesia Research Society