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The Splenectomized Dog: Do We Have to Say Farewell to an Established Hemorrhagic Shock Model?

Braz, José Reinaldo Cerqueira MD, PhD; Braz, Leandro Gobbo MD

doi: 10.1213/01.ANE.0000156675.24364.54
Letters to the Editor: Letters & Announcements

Department of Anesthesiology, UNESP School of Medicine, Botucatu, São Paulo, Brazil,

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In Response:

We agree with Kemming et al.’s comments on Mycoplasma haemocanis and its effects on red cells in dogs. However, according to information from our University’s Center for the Control of Infections Diseases in Animals, the prevalence of M. haemocanis in kennel-raised dogs supplied to research laboratories in Botucatu, São Paulo, Brazil is very low. In addition, the dogs used in our study (1) were considered healthy after clinical examination and normal erythrocyte count—see the Methods section of our article. In addition, our study was carried out in acutely splenectomized dogs. As M. haemocanis is a red cell parasite that causes disease mainly in immunosuppressed or previously splenectomized dogs, we are confident that its influence was not underestimated in our study.

José Reinaldo Cerqueira Braz, MD, PhD

Leandro Gobbo Braz, MD

Department of Anesthesiology

UNESP School of Medicine

Botucatu, São Paulo, Brazil

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1. Braz JRC, do Nascimento P Jr, Paiva Filho O et al. The systemic and gastrointestinal oxygenation effects of hemorrhage shock resuscitation with hypertonic saline and hypertonic saline 6% dextran-70: a comparative study in dogs. Anesth Analg 2004;99:536–46.
© 2005 International Anesthesia Research Society