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Featured Articles: Infographic

Got Oxygen? Hypoxia, Aging, and Its Contributions to POCD

Shah, Sonali; Weber, Garret MD*,; Nathan, Naveen MD

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doi: 10.1213/ANE.0000000000005560

In this issue of Anesthesia & Analgesia, Snyder et al1 explore postoperative cognitive dysfunction (POCD) and, specifically, the role of cerebral hypoxia. Mechanisms of cellular hypoxia are described that include increased cerebrovascular burden, excitotoxicity, and neuroinflammation among others as illustrated in this infographic. The authors offer an exhaustive, detailed description of the various processes that link cerebral hypoxia to the aging brain and offer insight into potential management strategies to better stratify patients. Future studies are required to further characterize the role of hypoxia and POCD.

    REFERENCES

    1. Snyder B, Simone SM, Giovannetti T, Floyd TF. Cerebral hypoxia: its role in age-related chronic and acute cognitive dysfunction Cerebral hypoxia: its role in age-related chronic and acute cognitive dysfunction. Anesth Analg. 2021;132:1502–1513.
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