Secondary Logo

Journal Logo

Featured Articles: Special Article

Society for Obstetric Anesthesia and Perinatology: Consensus Statement and Recommendations for Enhanced Recovery After Cesarean

Bollag, Laurent MD*; Lim, Grace MD, MS; Sultan, Pervez MBChB, FRCA, MD (Res); Habib, Ashraf S. MBBCh, MSc, MHSc, FRCA§; Landau, Ruth MD; Zakowski, Mark MD; Tiouririne, Mohamed MD#; Bhambhani, Sumita MD**; Carvalho, Brendan MBBCh, FRCA, MDCH

Author Information
doi: 10.1213/ANE.0000000000005257


The first Enhanced Recovery after Surgery (ERAS) pathways were developed in the 1990s–2000s and focused on recovery after colorectal surgery.1,2 Today, numerous ERAS protocols exist for multiple surgery types.3–6 Since 2012, the National Institute for Health and Care Excellence (NICE) guidelines from the United Kingdom encouraged institutions to implement ERAS protocols in their obstetric units.7 The widespread adoption of ERAS lies in successful standardization of perioperative patient management. Care pathways have the potential to limit the variability in patient care and therefore improve outcomes such as postoperative pain and hospital length of stay, without compromising patient outcomes or satisfaction.8–10 Currently, evidence exists supporting benefits of standardizing protocols on improving maternal and fetal outcomes.11,12 The ERAS Society published 3 distinct guidelines for antenatal, intraoperative, and postoperative care for women undergoing cesarean delivery.13–15 They provide a solid foundation from which clinicians can base their perioperative management of the patient undergoing elective cesarean delivery; however, they lack details regarding important peri- and intraoperative anesthesia-related areas of patient care.

This consensus statement focuses on anesthesia-related components of an enhanced recovery pathway for cesarean delivery and provides the level of evidence for each recommendation.

Improving Quality of Care

The Institute of Medicine defines health care quality as, “[t]he degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.”16 Intuitively, the value of enhanced recovery protocols in obstetrics may be different from other surgical models. Women undergoing cesarean delivery are generally young and healthy, and therefore less likely to require preoperative optimization or have surgical complications. They are also expected to take care of their neonate and are therefore motivated to recover quickly. The traditional markers of successful implementation of ERAS may be different with Enhanced Recovery After Cesarean delivery (ERAC). For instance, reduction in maternal length of stay is influenced by multiple factors including neonatal health state and breastfeeding success, and this metric should therefore be taken in context with other measures when evaluating ERAC success. ERAC can increase the value of health care provided, by improving the global quality of care and optimizing quality of recovery after cesarean delivery.

The goal of this consensus statement is to improve maternal and neonatal outcomes with evidence-based, patient-centered care using a standardized approach that optimizes recovery from cesarean delivery. Central to this goal is a culture of critically examining and applying current knowledge through quality improvement and collaboration.

The Society for Obstetric Anesthesia and Perinatology ERAC Consensus Statement

The Society for Obstetric Anesthesia and Perinatology (SOAP) is a US- based, international professional society exclusively dedicated to optimizing maternal and perinatal health outcomes. In October 2018, SOAP Board of Directors convened a committee to review best practices and existing literature on enhanced recovery after cesarean. A consensus committee was selected, with 6 members from 6 different academic centers across the United States. Weekly phone calls were performed for 10 months between January and October 2019. Assigned members collated information regarding potential pre-, intra-, and postoperative ERAC elements that were further evaluated and subsequently discussed. Additional interventions were added/amended based on committee feedback. Of note, when there was a paucity in obstetric-specific data, elements of the consensus statement were adapted from other successful enhanced recovery programs, such as colorectal or gynecological-oncological surgical specialties.1,7–10,17–19

Three additional consultants (A.S.H., R.L., P.S.) were invited to participate in the consensus decisions and to provide further input, and a draft consensus statement was presented and approved by the SOAP Board of Directors in May 2019. The consensus statement incorporates the best available evidence on each element, with focus on the obstetric patients, and maternal and neonatal outcomes. These ERAC elements are consistent with current practice guidelines for obstetrics and obstetric anesthesia, including those issued by the American Society of Anesthesiologists (ASA) Committee on Obstetric Anesthesia and SOAP as well as the American College of Obstetricians and Gynecologists (ACOG).20–24

We present the elements that a perioperative scheduled cesarean delivery–specific enhanced recovery program should include. Specific outcomes that these recommendations are designed to improve are often interrelated (eg, the prevention of intraoperative nausea and vomiting [IONV], multimodal analgesia, and shivering control are all expected to improve mothers comfort during the cesarean delivery and their birthing experience) and include postoperative duration of hospital stay, postoperative opioid requirement, breastfeeding success rate, maternal-neonatal bonding, patient satisfaction, and care experience.

The complete consensus statement is available online (, along with resources to assist with implementation, including sample patient handouts.25

What Is an ERAC Pathway?

ERAC is best conceptualized as a continuum of care, from preconception outreach, antepartum optimization, intrapartum care which includes the anesthetic management, and concluding with postpartum in-patient care and out-patient support. ERAC protocols aim to optimize patient outcomes by modifying the inflammation and metabolic changes associated with surgery by organizing multimodal evidence-based interventions into a specific care pathway. This consensus statement presents 25 specific recommendations that the committee believes define an ERAC pathway (Tables 1–3). Although the consensus statement was developed for scheduled cesarean deliveries, many of the elements of the pathway can be successfully applied to nonscheduled cesarean deliveries.

Class of Recommendations and Level of Evidence

Tables 1–3 present specific recommendations on ERAC elements for preoperative, intraoperative, and postoperative time frames. A focused literature review related to enhanced maternal and neonatal recovery after cesarean delivery was conducted for each recommendation by 2 committee members (preoperative period: S.B., M.T.; intraoperative period: G.L., M.Z.; postoperative period: L.B., B.C.) and then reviewed by the full committee. The existing evidence and strength of recommendations were evaluated for each of the elements by assigned committee members and subsequently discussed by the entire committee, in cases of disagreement, the level was up or downgraded until consensus was achieved. The 2016 American College of Cardiology (ACC) and American Heart Association (AHA) Clinical Practice Guideline Recommendation Classification Systems26 were used to evaluate each of the element’s level of evidence.


A total of 5 preoperative ERAC elements were identified (Table 1): (1) limited fasting intervals; (2) nonparticulate liquid carbohydrate loading; (3) patient education;

Table 1. - Preoperative ERAC Pathway Elements
Recommendation Action Comments Strength of recommendation Level of evidence
(1) Limit fasting interval • Solids up to 8 h before cesarean delivery Reduces aspiration risk while limiting hypovolemia, metabolic stress, and ketosis. Class IIb Level C-EO
• Clear fluids up to 2 h before cesarean delivery
• Data extrapolated from colorectal ERAS programs
ASA guidelines state 6–8 h based on the type of food ingested:
• A light meal or milk may be ingested for up to 6 h before elective procedures requiring general anesthesia, regional anesthesia, or procedural sedation and analgesia
• Additional fasting time (8 or more hours) may be needed in cases of patient intake of fried foods, fatty foods, or meat
(2) Nonparticulate liquid carbohydrate loading • Nonparticulate carbohydrate drink up to 2 h before cesarean delivery (nondiabetic women only)
• 45 g carbohydrate is recommended
• Examples: Gatorade 32 oz (54 g carbohydrate) clear apple juice 16 oz (56 g carbohydrate)
• Reduces maternal hypoglycemia and metabolic stress Class IIb Level C-EO
• The benefit of complex carbohydrate (eg, maltodextrin) drinks for cesarean delivery is currently undefined, and fetal effects unknown
• Can omit if mother is diabetic; follow institutional protocols for maternal diabetes/neonatal monitoring
• Most data are extrapolated from colorectal ERAS programs
• More data in cesarean population is needed specifically with respect to ideal type of carbohydrate, dose, and fetal-neonatal effects
(3) Patient education • Minimum: Handout or other standardized educational tool or interaction that includes precesarean delivery instructions, what to expect during cesarean delivery, and enhanced recovery information, provided at least 1 d before surgery • The goal of ERAC patient education is to set expectations, and to engage/empower the patient to participate more completely in their care plan and recovery
• Ideally, patient education takes place before the day of surgery
• Preoperative discussion should include ERAC goals in addition to the routine preoperative evaluation
• Patient education in general improves patient compliance with care pathways and improves outcomes in certain clinical settings; reduces patient anxiety and postoperative pain; supports patient empowerment
Class IIb Level C-NR
• Example: SOAP videos available on
• Ideal: Direct contact with patients with phone call/reminder or meeting before cesarean, to remind patient of ERAC goals
(4) Lactation/breastfeeding preparation and education • Minimum: Handout or other standardized tool or interaction that includes information on normal breastfeeding physiology, management of common lactation complications, and resources for breastfeeding support after discharge • Early breastfeeding improves newborn and maternal outcomes, including promoting emotional attachment, reducing infant infectious complications, and decreasing the risk for sudden infant death syndrome
• Breastfeeding is a public health priority because it is protective for downstream adverse health outcomes such as breast cancer and hypertension
• Every woman should be supported in her informed decision on infant feeding
Class IIa Level B-R
• Ideal: Structured prenatal classes with books, videos, and in-person lactation support in the hospital; referrals to breastfeeding support groups and/or lactation consultant after discharge
(5) Hemoglobin optimization All pregnant women should be screened for anemia per ACOG guidelines21 • Goal: Work with obstetric provider team during prenatal visits, to engage patient in understanding the importance of hemoglobin optimization; treat prenatal anemia appropriately
• Antepartum anemia is a significant predictor of postpartum anemia, which is linked to depression and fatigue
• Iron-deficiency anemia in pregnancy is linked to increased risk for low birth weight, preterm delivery, and perinatal mortality
Class IIa Level B-R
• Women with iron-deficiency anemia should be treated with supplemental orally, per os (or if refractory anemia with IV) iron in addition to prenatal vitamins
• Anemia other than iron-deficiency should be further evaluated
The included 5 preoperative elements aim to reduce fasting periods, engage patients and providers in the care plan, and promote physical health optimization. The 2016 ACC and AHA Clinical Practice Guideline Recommendation Classification Systems were used to evaluate each of the elements, based on the best available evidence.26
Abbreviations: ACC, American College of Cardiology; ACOG, American College of Obstetricians and Gynecologists; AHA, American Heart Association; ASA, American Society of Anesthesiologists; ERAC, Enhanced Recovery After Cesarean Delivery; ERAS, Enhanced Recovery After Surgery; IV, intravenous; SOAP, Society for Obstetric Anesthesia and Perinatology.

(4) lactation/breastfeeding education; (5) hemoglobin optimization.

Limit Fasting Interval (Class IIb, Level C-EO, Low-Grade Level of Evidence)

Oral intake up to the limits of the ASA guidelines is encouraged.35 Limiting preoperative fasting interval is a key component of all ERAS pathways, because it limits metabolic stress and ketosis.36 Curtailing these metabolic demands enables improved recovery quality and reduced length of stay after colorectal surgery.37 The data supporting the recommendations for limiting preoperative fasting period was derived from nonobstetric populations (Table 1).

Nonparticulate Liquid Carbohydrate Loading (Class IIb, Level C-EO, Low-Grade Level of Evidence)

In the obstetric population, a balance needs to be struck between the desire to limit preoperative fasting and selecting appropriate oral intake parameters to prevent aspiration in this high-risk population.20,35 For example, particulate carbohydrate loading is not advisable, given the historical context of lethal aspiration pneumonitis/pneumonia hazards that are well described in this patient cohort.38 Studies in nonlaboring women scheduled to undergo a cesarean delivery suggest that gastric emptying is not decreased compared to their nonpregnant counterparts.39 Therefore, carbohydrate loading with nonparticulate liquids (eg, clear apple juice) up to 2 hours before scheduled cesarean delivery is recommended.

Patient Education (Class IIb, Level C-NR, Moderate-Grade Level of Evidence)

Patient education, information material, and clear communication are essential to enhanced recovery pathways, as patient empowerment for active participation in their health care is vital to improving health outcomes.37,40–43 Malpractice claims, a potential surrogate for care quality, are lower among physicians who emphasize a positive communication style and orientate toward patient education in clinical encounters.42 For obstetric patients, patient activation and prenatal engagement, both of which emphasize patient counseling and education, are associated with positive patient experience and improved obstetric outcomes.44

Lactation/Breastfeeding Education (Class IIa, Level B-R, Moderate-Grade Level of Evidence)

Lactation/breastfeeding education is an important element of postpartum recovery for breastfeeding mothers and their infants.22,23,45–49 Numerous professional organizations, including the World Health Organization (WHO) and American Academy of Pediatrics (AAP), recognize the many medical and neurodevelopmental advantages of breastfeeding, and consider infant nutrition to be a public health issue rather than a lifestyle choice.45 The AAP recommends exclusive breastfeeding for 6 months and continued breastfeeding alongside solid food for 1 year or longer as desired by both mother and infant. Hospitals should therefore encourage and support the initiation and maintenance of breastfeeding.45 The US Surgeon General, Centers for Disease Control and Prevention (CDC), and The Joint Commission have issued strategies to facilitate breastfeeding in the hospital and community settings, and highlight the potential for improved breastfeeding end points with the implementation of breastfeeding-friendly practices.50–52

Hemoglobin Optimization (Class IIa, Level B-R, Moderate-Grade Level of Evidence)

Many health benefits are associated with perinatal anemia prevention and treatment, including transfusion avoidance, improved cognition and mood, and quicker postpartum recovery.21,53–57 One randomized controlled trial suggested that early prenatal iron supplementation improved postpartum depression screening scores,56 although its effect on clinical diagnosis of depression was not assessed. For other surgeries, preoperative anemia optimization is recommended as part of a multimodal patient blood management approach.54 Preoperative anemia optimization for cesarean delivery is particularly important given that: (1) pregnancy is associated with increased blood volume and dilutional anemia; (2) cesarean delivery is associated with blood loss that is higher than most abdominal surgeries; (3) prenatal anemia is a strong predictor of severe postpartum anemia55; (4) ACOG and CDC recommend screening, prevention, and treatment of anemia in pregnancy.21,53

In summary, preoperative ERAC element recommendations include patient education, minimizing preoperative fasting periods, and nonparticulate carbohydrate loading up to 2 hours before scheduled delivery, lactation/breastfeeding education, and hemoglobin optimization.


Table 2. - Intraoperative ERAC Pathway Elements
Recommendation Action Comments Strength of recommendation Level of evidence
(1) Prevent spinal anesthesia–induced hypotension • Maintain blood pressure at baseline • Spinal anesthesia–associated hypotension is primarily an afterload-driven problem Class I Level A
• Optimally managed with prophylactic vasopressor infusion, for example, phenylephrine (or norepinephrine) infusion
• Goal is to prevent intraoperative nausea/vomiting after spinal anesthesia and maintain uteroplacental perfusion
• Vasopressor regimen may need to be modified in women with preeclampsia as the degree of hypotension with spinal anesthesia may be less than that in nonpreeclamptics
• Data are well supported in literature from the obstetric population
(2) Maintain normothermia • Active warming: • Consider active warming starting preoperatively Class I Level C
• In-line IV fluid warmer
• Forced air warming
• Keep the OR temperature ideally >72°F or 23.0°C (Joint Commission guidance)
(3) Optimal uterotonic administration • Use lowest effective dose of uterotonic necessary to achieve adequate uterine tone and minimize side effects • In the case of hemorrhage caused by uterine atony, transition from ERAC to institutional hemorrhage resuscitation protocol Class II Level A
-Elective cesarean delivery:
Bolus 1 IU oxytocin; start oxytocin infusion at 2.5–7.5 IU·h−1 (0.04–0.125 IU·min−1)
-Intrapartum cesarean delivery:
3 IU oxytocin over ≥30 s; start oxytocin infusion at 7.5–15 IU·h−1 (0.125–0.25 IU·min−1)27
(4) Antibiotic prophylaxis • Antibiotic prophylaxis dosed before skin incision (do not wait until after cord clamping) Follow ACOG guidelines24 Class I Level A
(5) IONV/PONV prophylaxis • Prophylactic vasopressor infusion (see above) to decrease hypotension-associated IONV• Address uterine exteriorization and abdominal saline irrigation with surgeon• Combination of at least 2 prophylactic IV antiemetics with different mechanisms of action. Examples:
5HT3 antagonist (eg, ondansetron 4 mg)
Glucocorticoid (eg, dexamethasone 4 mg)
D2 receptors antagonist (eg, metoclopramide 10 mg)
• IONV/PONV is a major stressor for the mother and should be avoided, bearing in mind the different etiologies Class I Level B
IONV/PONV prophylaxis
• Limiting/avoiding uterine exteriorization which is associated with IONV and delayed bowel function recovery Class IIa Level C-LD
uterine exteriorization
• Abdominal saline irrigation may worsen IONV and PONV
• Dexamethasone is effective for PONV and not IONV due to delayed onset of action
• Metoclopramide is effective for IONV but not PONV
(6) Initiate multimodal analgesia Neuraxial long-acting opioidExample:• IT morphine 50–150 µgor• Epidural morphine 1–3 mgNonopioid analgesia started in OR unless contraindicated:1. Ketorolac 15–30 mg IV after peritoneum closed2. APAP IV after delivery or orally, per os before or after deliveryConsider local anesthetic wound infiltration or regional blocks such as TAP or QLB if neuraxial morphine is not administered • Use neuraxial doses consistent with SOAP Center of Excellence criteria Class I Level A
Link: Data to support preemptive analgesia in cesarean delivery are limited
• Nonopioid analgesia is ideally started before the onset of pain
• Rectal APAP may be an alternative but has lower bioavailability
• The role of wound infiltration and other regional blocks for postcesarean pain should be considered in select cases, for example, in women who could not receive neuraxial morphine, or other multimodal analgesia regimen components, or patients at risk for severe pain
(7) Promote breastfeeding and maternal-infant bonding • Skin-to-skin contact should occur as soon as possible in the operating room as appropriate based on maternal/neonatal condition • Skin-to-skin contact intraoperatively supports the “golden hour” of breastfeeding initiation within 1 h of birth Class IIa Level C
• Supports a safe transition of the infant from intrauterine life to extrauterine life
• Facilitates mother-infant bonding
• May require additional nurse support intraoperatively (follow hospital guideline for safe positioning for the newborn during skin-to-skin contact)
• Ideally the responsibility of a nonanesthesia care team member
• Ways to facilitate skin-to-skin contact intraoperatively include moving electrocardiogram leads and electrodes to the patients back to clear space on the chest; moving equipment to allow nursing personnel space to safely accomplish skin-to-skin contact; maintain efforts to keep maternal/neonatal temperature (eg, forced air warmer, warmed blankets)
(8) Intravenous fluid optimization • Limit intravenous fluids to <3 L for routine cases • In the case of hemorrhage, transition from ERAC to institutional hemorrhage resuscitation protocol Class IIa Level C
• Spinal anesthesia–associated hypotension in cesarean delivery should be primarily managed with vasopressors, instead of fluids
• Ideal intravenous fluid parameters/goals in cesarean delivery are not well established
(9) Delayed umbilical cord clamping ACOG recommends delay in umbilical cord clamping in vigorous term and preterm infants for at least 30–60 s after birth28 • Benefits: Term: improved iron stores, developmental benefits; preterm: improved transitional circulation, reduced need for transfusion, lower risk of necrotizing enterocolitis and intraventricular hemorrhage Class I Level A
• Does not increase maternal risk for blood loss or transfusion
• The ability to provide delayed cord clamping may vary among institutions and settings
Delayed cord clamping should be deferred in certain situations (eg, maternal instability, fetal/neonatal need for immediate resuscitation)28
The included 9 intraoperative elements aim to prevent spinal anesthesia–induced hypotension and IONV, initiate multimodal analgesia, support breastfeeding and maternal-infant bonding, and optimize fluid management and fetal outcomes. The 2016 ACC and AHA Clinical Practice Guideline Recommendation Classification Systems were used to evaluate each of the elements, based on the best available evidence.26
Abbreviations: 5HT3, 5 hydroxytryptamine receptor; ACC, American College of Cardiology; ACOG, American College of Obstetricians and Gynecologists; AHA, American Heart Association; APAP, acetaminophen; D2, dopamine receptor; ERAC, Enhanced Recovery After Cesarean Delivery; IONV, intraoperative nausea and vomiting; IT, intrathecal; IV, intravenous; OR, operation room; PONV, postoperative nausea and vomiting; QLB, quadratus lumborum block; SOAP, Society for Obstetric Anesthesia and Perinatology; TAP, transversus abdominis plane block.

A total of 9 intraoperative ERAC elements were identified (Table 2): (1) prevention of spinal-induced hypotension; (2) maintenance of normothermia; (3) optimized uterotonic administration; (4) antibiotic prophylaxis; (5) IONV and postoperative nausea and vomiting (PONV) prophylaxis; (6) multimodal analgesia initiation; (7) promotion of breastfeeding and maternal-infant bonding; (8) intravenous fluid optimization, and (9) delayed umbilical cord clamping.

Spinal Anesthesia–Induced Hypotension Prevention (Class I, Level A, High-Grade Level of Evidence)

Preventing spinal-induced hypotension is an important strategy to enhance maternal and neonatal outcomes in cesarean delivery.38 Fetal perfusion is dependent on uteroplacental blood flow, which lacks autoregulation, making it directly dependent on uterine perfusion pressure and inversely proportional to uterine vascular resistance. Current evidence supports the routine use of prophylactic phenylephrine infusion started immediately after injection of spinal anesthesia medications.38,58 A crystalloid fluid coload (1 L administered immediately and rapidly after spinal injection) is preferable to a preload, and in combination with vasopressors significantly reduces the incidence of spinal-induced hypotension.58 Spinal-induced hypotension during cesarean delivery should be managed with vasopressor agents having primarily direct alpha activity (eg, phenylephrine or norepinephrine), while fluids should remain a complementary intervention. Since IONV during cesarean delivery is commonly the result of spinal-induced hypotension, the above-recommended management techniques can be effective at reducing the incidence of IONV during cesarean delivery. Among women randomized to receive a prophylactic phenylephrine infusion compared to intermittent bolus regimens, umbilical artery pH and base excess were improved and the incidence of maternal IONV was lower.58

Normothermia Maintenance (Class I, Level C, Low-Grade Level of Evidence)

Maintaining normothermia confers multiple perioperative maternal-neonatal benefits including reduced surgical site infection risk, shorter hospital length of stay (as shown in nonobstetric surgical settings), and improved neonatal umbilical artery pH and Apgar scores.59–64 One meta-analysis found that active warming for elective cesarean delivery significantly decreased the incidence of hypothermia and perioperative shivering.63 Preferred methods of facilitating maternal-neonatal warming in cesarean delivery include preoperative patient warming, and intraoperative fluid and forced air warming. A higher ambient operating room temperature set at 72°F (23.0 °C) is also recommended.65

Uterotonic Administration (Class II, Level A, High-Grade Level of Evidence)

Optimal uterotonic administration during cesarean delivery is important to prevent and treat uterine atony and associated postpartum hemorrhage (PPH).66,67 However, appropriate dosing of these medications is important to avoid drug-related side effects. It is advisable to use the lowest effective dose of uterotonics needed to achieve adequate uterine tone to minimize side effects. Undesirable effects of uterotonic agents include flushing, nausea and vomiting, tachycardia, hypotension, delayed water retention, hyponatremia and seizures (oxytocin), bronchospasm (prostaglandins), hypertension (ergot alkaloids), and drug errors (a risk associated with any unnecessarily administered drug).27,66 A suggested uterotonic dosing regimen can be found in Table 2. Large and rapidly administered oxytocin boluses should be avoided to minimize side effects. Intrapartum cesarean delivery oxytocin dosing requirements are several fold higher than for elective cases without prior oxytocin exposure.68

Antibiotic Prophylaxis (Class I, Level A, High-Grade Level of Evidence)

Appropriate antibiotic prophylaxis is critical for prevention of surgical site infection. ACOG guidelines consider cefazolin 2 g as a first-line antibiotic, with the addition of azithromycin in appropriate cesarean deliveries (such as in the presence of ruptured membranes).24,69 Prophylactic antibiotics should be administered before incision, rather than after cord clamping. Preincision administration improves prophylaxis effectiveness without increasing risks to the fetus.24

IONV/PONV Prophylaxis (Class I, Level B, Moderate-Grade Level of Evidence)

Adding lipophilic opioids such as fentanyl or sufentanil to spinal anesthesia with local anesthetics enhances intraoperative anesthesia,70 reduces the total required dose of local anesthetic and thereby decreases spinal hypotension, reduces intraoperative pain and need for rescue analgesics, and decreases IONV.38,71 PONV prophylaxis elements for cesarean delivery include the use of at least 2 antiemetic agents, for example, ondansetron and dexamethasone.72–74 Metoclopramide is effective for IONV prevention, while dexamethasone’s pharmacological profile make it a better option for PONV prophylaxis.75 Evidence supports the avoidance of intraabdominal saline irrigation, which does not reduce the incidence of infectious complications but does increase the incidence of IONV and PONV.76,77

Avoiding uterine exteriorization has also been suggested as a strategy to reduce IONV,78 intra- and postoperative pain, and time-to-return of bowel function following cesarean delivery; however, evidence regarding its effectiveness in preventing IONV is conflicting. The committee favored avoiding uterine exteriorization because studies with IONV as the primary outcome after uterine exteriorization suggested benefits with not externalizing the uterus.78–84

Multimodal Analgesia (Class I, Level A, High-Grade Level of Evidence)

Initiating multimodal analgesia includes administration of intrathecal morphine (50–150 µg) or epidural morphine (1–3 mg); nonopioid analgesia, for example, nonsteroidal anti-inflammatory drugs and acetaminophen (started in the operating room unless contraindicated); and supplemental local anesthetic wound infiltration or truncal blocks in select cases (eg, if unable to receive the above-recommended drugs).20,38,85,86 An emphasis on regular scheduled nonopioid analgesia commencing before the onset of pain (ie, immediately after delivery of fetus and not upon first pain request) should be central in these multimodal analgesic regimens.

Breastfeeding and Maternal-Infant Bonding (Class IIa, Level C, Low-Grade Level of Evidence)

Skin-to-skin contact immediately after delivery improves breastfeeding success and promotes maternal-infant bonding.47–49 The Association of Women’s Health, Obstetric and Neonatal Nurses support skin-to-skin contact to promote lactation and breastfeeding.49 One quality improvement project found that early skin-to-skin contact in the operating room during cesarean delivery was feasible and increased breastfeeding initiation behaviors.47 These infants had lower rates of formula supplementation in the hospital. A meta-analysis, including 38 randomized controlled studies, showed that skin-to-skin contact promoted breastfeeding among healthy infants, and found potential physiologic benefits for infants in transitioning to extrauterine life.48 Although a randomized trial did not find this physiologic benefit for infants, it did not report elevated risks associated with early skin-to-skin contact.87

Intravenous Fluid Optimization (Class IIa, Level C, Low-Grade Level of Evidence)

Goal-directed intraoperative fluid management is a mainstay of many ERAS pathways (Table 2). In colorectal surgery, the avoidance of both volume overload (that may affect anastomotic integrity) and under-resuscitation (that may cause end-organ hypoperfusion) are important.37 As previously stated, prevention and treatment of spinal anesthesia–induced hypotension should focus on the use of vasopressors in conjunction with judicious coadministration of fluids. Ideal fluid management parameters or goals in cesarean delivery have not been established. Expert consensus suggests limiting intravenous fluids to <3 L for routine cases. Avoidance of excessive volumes is important given the ubiquitous coadministration of oxytocin for active management of the third stage of labor, which increases postoperative intravascular fluid shifts and the risk of hyponatremia.66,88 Early recognition and preparedness for PPH, a commonly preventable cause of serious maternal morbidity,11 is of critical importance. In the setting of PPH, fluid and blood administration as part of hemorrhage protocols supersede ERAC fluid guidelines. Data supporting the recommendations for intraoperative fluid management were derived from nonobstetric surgical populations (Table 2).

Delayed Cord Clamping (Class I, Level A, High-Grade Level of Evidence)

Delayed umbilical cord clamping improves neonatal hemoglobin levels at birth and improves iron stores in term infants, which may have neurodevelopmental benefits.89 Preterm infants benefit from delayed cord clamping by improved circulation, greater red cell volume, reduced transfusion risk, and decreased risk for necrotizing enterocolitis and cerebral hemorrhage. There may be a small increased risk for neonatal jaundice associated with this technique, and therefore systems should be set up for monitoring and treating jaundice in these infants. Delayed cord clamping does not significantly increase perioperative blood loss or the incidence of maternal postoperative anemia.28 ACOG currently recommends a delay in umbilical cord clamping in vigorous term and preterm infants for at least 30–60 seconds after birth.89 Patient-physician judgments should determine whether delayed cord clamping is performed in setting of PPH or high-risk deliveries.

In summary, intraoperative ERAC element recommendations include (1) prevention of spinal-induced hypotension, (2) maintenance of normothermia, (3) optimization of uterotonic administration, (4) antibiotic prophylaxis, (5) IONV and PONV prophylaxis, (6) multimodal analgesia initiation, (7) promotion of breastfeeding and maternal-infant bonding, (8) intravenous fluid optimization, and (9) delayed cord clamping.


Table 3. - Postoperative ERAC Pathway Elements
Recommendation Action Comments Strength of Recommendation Level of Evidence
(1) Early oral intake • Ice chips and/or water within 60 min postcesarean admission to PACU Early oral intake leads to:
• Accelerated return of bowel function
• Reduced hospital length of stay
• No increased rates of complication
• No increased risk of postoperative nausea or vomiting
• Reduced postoperative catabolism
• Improved insulin sensitivity
• Reduced surgical stress response
Class IIb For cesarean delivery Level C-EO
• Heparin/saline lock the IV early once oxytocin infusion complete, tolerating fluids, and urine output adequate
• Advance to regular diet ideally within 4 h postcesarean, as tolerated
(2) Early mobilization • Ambulate only after adequate return of motor function Early mobilization decreases:
• Insulin resistance
• Muscle atrophy
• Hypoxia
• Venous thromboembolism
• Length of stayRemove barriers to early mobilization:
• IV poles
• Urinary catheters
• Poor pain control
• Sedation
• Dizziness
• Slow block regression
Class I Level B-NR
0–8 h postoperatively:
• Sit on edge of bed
• Out of bed to chair
• Ambulation as tolerated
8–24 h postoperatively:
• Ambulation as tolerated
• Walk: 1–2 times (or more) in hall
24–48 h postoperatively:
• Walk: 3–4 times (or more) in hall
• Out of bed for 8 h
(3) Promotion of resting periods • Optimize sleep and rest • Fatigue potentially impacts cognitive function, depression, pain, maternal-infant bonding, and risk of respiratory depression Class IIb Level C-EO
• Encourage clustered interventions (eg, vital signs assessments in coordination with analgesic administration; timing of oral analgesics contemporaneously)
Appropriate use of postoperative monitoring (see SOAP neuraxial morphine monitoring consensus statement29)
(4) Early urinary catheter removal • Urinary catheter removed by 6–12 h postpartum Benefits include:
• Improved ambulation
• Reduced length of stay
• Lower rates of symptomatic UTIEarlier catheter removal may be associated with higher rates of urinary retention and need for recatheterizationDose of neuraxial local anesthetic and opioid can impact catheter removal time
Class IIb Level C-EO
• Construct protocols to establish criteria for appropriate removal and to manage postcatheter removal urinary retention
(5) Venous thromboembolism prophylaxis Follow institutional practices as per ACOG and ACCP guidelines30–33 • Cesarean delivery approximately doubles the risk of venous thromboembolism compared to vaginal delivery, but in otherwise healthy patients the absolute risk is low Class I Level A
• ACOG recommends mechanical thromboembolism prophylaxis for all women not already receiving pharmacologic thromboprophylaxis33
(6) Facilitate early discharge • Standardize discharge planning and coordinate care starting preoperatively • Discharge planning on POD 1 should ideally include pediatric, lactation, and contraceptive planning Class IIb Level C-EO
• Establish patient-oriented goals early
• Personalize/patient-centered opioid prescribing at discharge
• Use metrics to monitor patient progress in meeting early discharge criteria
(7) Anemia remediation • Screen and treat anemia • Hb check on POD 1 or 2 should be considered in patients with severe intraoperative bleeding Class I Level A
(8) Breastfeeding support • Robust lactation support per institutional guideline • Should start immediately after birth by offering skin-to-skin care and continued throughout hospitalization Class I Level A
• Support of the “golden hour” to help women initiate breastfeeding within 1 h of birth
• Initial skin-to-skin contact should continue uninterrupted until the completion of the first breastfeeding
• In the case of formula fed infants, initial skin-to-skin contact should continue as uninterrupted as possible for at least 1 h
• After the initial period of skin-to-skin contact, mothers should be encouraged to continue this type of care as much as possible during the hospital stay
• Provide lactation consulting and educational material (10 steps to successful breastfeeding as documented in the Joint Statement by UNICEF and WHO: Baby Friendly Hospital Initiative34)
(9) Multimodal analgesia Multimodal analgesia protocols include:
• Low-dose long-acting neuraxial opioid such as morphine (see above)
• Scheduled NSAID
• Scheduled APAP
• Local anesthetic techniques as indicated
Multimodal analgesia should be used to:
• Reduce pain
• Improve mobilization• Limit IV opioids in PACU
• Limit opioids in hospital
• Limit opioids at discharge
Opioids are associated with nausea/vomiting, sedation, fatigue, ileus, constipation, misuse/addiction risk
• Multimodal analgesia (including NSAID + APAP) decrease opioid use/side effects by 30%
• See SOAP Center of Excellence criteria Link:
• Expectation management25
• Truncal blocks (TAP, QLB) or continuous wound infiltration available when neuraxial morphine cannot be given, or as a rescue technique when severe breakthrough pain despite the use of neuraxial morphine
• TAP blocks does not provide significant improvement when given in addition to neuraxial morphine and scheduled NSAID/APAP
• Gabapentinoids have not been shown to have significant benefit in routine cesarean; may be appropriate in select patients; use caution in patients on methadone or other QTc prolonging medications
Class I Level B-NR
• APAP 650–1000 mg orally, per os q6h scheduled
• Ibuprofen 600 mg orally, per os q6h scheduled after IV ketorolac 15–30 mg that is given after delivery in OR, or naproxen 500 mg orally, per os twice a day or other NSAID
• Oxycodone 2.5–5 mg orally, per os q4h PRN pain
• Preemptive or rescue supplemental regional blocks as indicated
(10) Glycemic control • Patient with diabetes ideally first case of day • Hyperglycemia (>180–200 mg/dL) is associated with poor outcomes including infection and delayed wound healing Class I Level A
• Maintain normoglycemia (<180–200 mg/dL); check maternal/neonatal glucose per hospital protocol
• Data based on nonobstetric populations

A total of 11 postoperative ERAC elements were identified (Table 3): (1) early oral intake, (2) early mobilization, (3) resting periods promotion, (4) early urinary catheter removal, (5) venous thromboembolism (VTE) prophylaxis, (6) early discharge facilitation, (7) anemia remediation, (8) breastfeeding support, (9) multimodal analgesia, (10) glycemic control, and (11) return of bowel function promotion.

Early Oral Intake (Class IIb, Level C-EO, Low-Grade Level of Evidence)

The goals of early oral intake are to accelerate return of bowel function and reduce postoperative catabolism. Early oral intake improves insulin sensitivity and mitigates the surgical stress response.37,90–95 Early oral intake is not associated with increased rates of gastrointestinal complications or risk for PONV in the nonobstetric and obstetric population. A meta-analysis, including 11 studies found that early oral intake after cesarean delivery enhances the return of bowel function and does not increase the risk of postoperative complications.90,92

Early Mobilization (Class I, Level B-NR, Moderate-Grade Level of Evidence)

Early mobilization reduces insulin resistance, venous thromboembolic risk, and hospital length of stay.96–99Table 3 provides examples of time-based goals for ambulation postcesarean delivery.100 For example, getting out of bed to a chair or ambulating within 8 hours as tolerated is a recommended goal. Barriers to early mobilization such as intravenous poles, urinary catheters, and poor pain control should be removed. Data supporting these recommendations were derived from nonobstetric populations (Table 3).

Resting Periods (Class IIb, Level C-EO, Low-Grade Level of Evidence)

Minimizing interruptions from visitors and health care providers encourage maternal resting periods. Maternal fatigue may negatively impact cognitive function, depression, mood, maternal-infant bonding, and increase the risk of respiratory depression.101 Practices that support these goals include clustering interventions such as assessment of vital signs, scheduled analgesic administration, and patient-appropriate postoperative monitoring. The 2019 SOAP respiratory monitoring consensus statement outlines patient-centered monitoring options in more detail.29

Early Urinary Catheter Removal (Class IIb, Level C-EO, Low-Grade Level of Evidence)

Early urinary catheter removal is important to support early mobilization goals. Other benefits include facilitating ambulation, shortening length of hospital stay, and lowering rates of symptomatic urinary tract infections.102–105 Neuraxial local anesthetic dose and particularly long-acting neuraxial opioids can increase the duration of detrusor muscle dysfunction and delay catheter removal times.103 Early urinary catheter removal must be balanced against increased risk of recatheterization. Data supporting these recommendations were derived from nonobstetric surgical populations (Table 3).

VTE Prophylaxis (Class I, Level A, High-Grade Level of Evidence)

Modern VTE prophylaxis goals in cesarean delivery96,106 include mechanical thromboprophylaxis for all women not already receiving pharmacologic thromboprophylaxis with low-molecular-weight heparin or unfractionated heparin (ACOG and American College of Chest Physicians, ACCP guidelines) unless contraindicated.30–33,96,106

Early Discharge (Class IIb, Level C-EO, Low-Grade Level of Evidence)

Facilitating early discharge ideally starts with establishing patient-oriented goals preoperatively, and encompasses elements such as neonatal care planning, lactation education, and contraception planning. Patient and support person education strategies in addition to patient self-empowerment for active participation in their health care are emphasized.107

Anemia Remediation (Class I, Level A, High-Grade Level of Evidence)

Anemia remediation includes early recognition and treatment of peripartum hemorrhage and management of postpartum anemia. Routinely checking postpartum laboratory tests in low-risk cohorts is not necessary, and routine hemoglobin checks on postoperative day 1 or 2 should be reserved for patients with significant (eg, >1 L) intraoperative bleeding or preexisting anemia.21,53–57 Although oral or intravenous formulations are acceptable for treatment of iron-deficiency anemia, 1 meta-analysis suggests intravenous formulations may offer increased efficacy (higher hemoglobin levels at 6 weeks postpartum) compared to oral administration, without increased risk of side effects.57 Recent reports describe the association between postpartum iron-deficiency anemia and postpartum anxiety and depression, emphasizing the importance of anemia remediation in preventing postpartum morbidity.108–110 Of note, there is no evidence that liberal transfusion policies improves maternal outcomes and transfusion reactions are more common in pregnant and postpartum women compared to their nonpregnant peers.111

Breastfeeding Support (Class I, Level A, High-Grade Level of Evidence)

Lactation education and counseling should continue throughout the hospital stay in accordance with the Joint Statement by United Nations International Children’s Emergency Fund (UNICEF) and WHO.34

Multimodal Analgesia (Class I, Level B-NR, Moderate-Grade Level of Evidence)

Multimodal analgesia in the postpartum period facilitates a reduction of pain, improves mobility, limits intravenous opioid requirement, and reduces in-hospital and discharge opioid use.112–115 These goals are accomplished by low-dose long-acting neuraxial opioids such as morphine (see “Intraoperative” section), scheduled nonsteroidal anti-inflammatory drugs, and scheduled acetaminophen.85,86,116–119 Local anesthetic techniques, including wound infiltration, transversus abdominis plane (TAP), and quadratus lumborum blocks (QLB) should also be leveraged when indicated (Table 2).

Glycemic Control (Class I, Level A, High-Grade Level of Evidence)

Avoidance of hyperglycemia (>180–200 mg/dL) is desirable because perioperative hyperglycemia increases risk of surgical site infection and delayed wound healing.120–122 Strategies to maintain normoglycemia include scheduling patients with insulin-dependent diabetes early in the day and checking maternal-neonatal glucose parameters per institutional protocol. These recommendations were derived from nonobstetric populations (Table 3).

Return of Bowel Function (Class IIb, Level C-EO, Low-Grade Level of Evidence)

Promoting return of bowel function emphasizes the use of multiple pro re nata bowel medications such as docusate and simethicone, minimizing opioid use, providing adequate hydration and encouraging mobilization.3790 These recommendations were derived from nonobstetric populations (Table 3).

In summary, postoperative ERAC element recommendations include promotion of (1) early oral intake, (2) early mobilization, (3) resting periods, (4) early urinary catheter removal, (5) VTE prophylaxis, (6) facilitation of early discharge, (7) anemia remediation, (8) breastfeeding support, (9) multimodal analgesia, (10) glycemic control, and (11) early return of bowel function.


Considerations for enhanced recovery pathways for cesarean deliveries differ significantly from those proposed after other surgical procedures, in that unique and essential elements for both maternal and fetal/neonatal care goals, standards and outcomes are necessary. Importantly, ensuring women’s ability to care for their newborn is crucial, which requires optimization of pain management and achievement of specific milestones by the time of hospital discharge. The overarching goal is to improve maternal outcomes without compromising measures of patient safety including maternal readmission and complication rates. While it is desirable to reduce postpartum depression, improve neonatal safety, reduce chronic pain, and decrease maternal morbidity (eg, surgical site infection, acute kidney injury, and wound dehiscence), future research needs to evaluate ERAC effects on these rarer outcomes.

Implementation of ERAC pathways for obstetric patients requires highly functional relationships between hospital systems and local cultural factors to support each element. ERAC pathways improve maternal and infant outcomes, enhance the patient experience, and support a local culture of growth orientation and commitment to continuous improvement and high quality of clinical care. Inherent to enhanced recovery pathways is ongoing interdisciplinary quality improvement and auditing of processes and outcomes to continuously adapt and improve individual ERAC protocols.

Due to relatively limited, high-quality evidence supporting enhanced recovery elements specific to obstetric populations, several recommendations presented here are based on low or very low-quality evidence or expert consensus. Strongest evidence (level 1 A) exists for intraoperative and postoperative recommendations, such as avoidance of spinal-induced hypotension to prevent IONV, implementation of multimodal analgesia and delayed cord clamping. Postoperative recommendations with strong evidence (level 1 A) are early mobilization, glycemic control, and use of multimodal analgesia.

There is minimal evidence of specific effects of individual elements of ERAC protocols; however, recommended elements proposed here have been evaluated together in different bundles and resulted in improved maternal and neonatal outcomes.123

A limitation of this consensus statement is that no obstetricians or nurses were invited to participate, yet several recommendations primarily apply to obstetric providers and nurses. However, as perioperative specialists, it is the responsibility of obstetric anesthesiologists to promote and facilitate these important elements of an enhanced recovery program to all, rather than on a case-by-case basis, and ensure they are built into ERAC pathways. There is no international consensus regarding which specific outcomes should be monitored in perioperative enhanced recovery pathway studies. Future research should therefore focus on providing high-quality data clarifying which pathway elements, or combinations thereof, best enhance recovery. More study is required to facilitate consensus among the various ERAC protocols that are utilized while considering the impact of local practices. Other areas of knowledge gaps include how to best initiate, support, and maintain ERAC system changes, and how to optimally involve and motivate patients to be part of and comply with enhanced recovery care pathways.


Name: Laurent Bollag, MD.

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Grace Lim, MD, MS.

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Pervez Sultan, MBChB, FRCA, MD (Res).

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Ashraf S. Habib, MBBCh, MSc, FRCA.

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Ruth Landau, MD.

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Mark Zakowski, MD.

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Mohamed Tiouririne, MD.

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Sumita Bhambhani, MD.

Contribution: This author helped write the manuscript and approve the final manuscript.

Name: Brendan Carvalho, MBBCh, FRCA, MDCH.

Contribution: This author helped write the manuscript and approve the final manuscript.

This manuscript was handled by: Jill M. Mhyre, MD.


    1. Basse L, Hjort Jakobsen D, Billesbølle P, Werner M, Kehlet H. A clinical pathway to accelerate recovery after colonic resection. Ann Surg. 2000;232:51–57.
    2. Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg. 2017;152:292–298.
    3. Gustafsson UO, Scott MJ, Hubner M, et al. Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations: 2018. World J Surg. 2019;43:659–695.
    4. Nelson G, Bakkum-Gamez J, Kalogera E, et al. Guidelines for perioperative care in gynecologic/oncology: Enhanced Recovery After Surgery (ERAS) Society recommendations-2019 update. Int J Gynecol Cancer. 2019;29:651–668.
    5. Nelson G, Altman AD, Nick A, et al. Guidelines for pre- and intra-operative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations–part I. Gynecol Oncol. 2016;140:313–322.
    6. Nelson G, Altman AD, Nick A, et al. Guidelines for postoperative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations–part II. Gynecol Oncol. 2016;140:323–332.
    7. National Institute for Health and Care Excellence (NICE). Caesarean section - Clinical Guideline. Availabel at: Accessed May 5, 2020.
    8. Khan S, Wilson T, Ahmed J, Owais A, MacFie J. Quality of life and patient satisfaction with enhanced recovery protocols. Colorectal Dis. 2010;12:1175–1182.
    9. Li D, Jensen CC. Patient satisfaction and quality of life with enhanced recovery protocols. Clin Colon Rectal Surg. 2019;32:138–144.
    10. Machin JT, Phillips S, Parker M, Carrannante J, Hearth MW. Patient satisfaction with the use of an enhanced recovery programme for primary arthroplasty. Ann R Coll Surg Engl. 2013;95:577–581.
    11. Main EK, Goffman D, Scavone BM, et al.; National Parternship for Maternal Safety; Council for Patient Safety in Women’s Health Care. National Partnership for Maternal Safety: consensus bundle on obstetric hemorrhage. Anesth Analg. 2015;121:142–148.
    12. Mann S, Pratt S, Gluck P, et al. Assessing quality obstetrical care: development of standardized measures. Jt Comm J Qual Patient Saf. 2006;32:497–505.
    13. Wilson RD, Caughey AB, Wood SL, et al. Guidelines for antenatal and preoperative care in cesarean delivery: Enhanced Recovery After Surgery Society recommendations (part 1). Am J Obstet Gynecol. 2018;219:523.e1–523.e15.
    14. Caughey AB, Wood SL, Macones GA, et al. Guidelines for intraoperative care in cesarean delivery: Enhanced Recovery After Surgery Society Recommendations (part 2). Am J Obstet Gynecol. 2018;219:533–544.
    15. Macones GA, Caughey AB, Wood SL, et al. Guidelines for postoperative care in cesarean delivery: Enhanced Recovery After Surgery (ERAS) Society recommendations (part 3). Am J Obstet Gynecol. 2019;221:247.e1–247.e9.
    16. Baker A. Institute of Medicine (US) Committee on Quality of Health Care in America. In: Crossing the Quality Chasm: A New Health System for the 21st Century. 2001.National Academies Press (US);
    17. Wilmore DW, Kehlet H. Management of patients in fast track surgery. BMJ. 2001;322:473–476.
    18. Brethauer SA, Grieco A, Fraker T, et al. Employing enhanced recovery goals in bariatric surgery (ENERGY): a national quality improvement project using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program. Surg Obes Relat Dis. 2019;15:1977–1989.
    19. Djaladat H, Daneshmand S. Enhanced recovery pathway following radical cystectomy. Curr Opin Urol. 2014;24:135–139.
    20. Practice guidelines for obstetric anesthesia: an updated report by the American Society of anesthesiologists task force on obstetric anesthesia and the society for obstetric anesthesia and perinatology. Anesthesiology. 2016;124:270–300.
    21. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 95: anemia in pregnancy. Obstet Gynecol. 2008;112:201–207.
    22. American College of Obstetricians and Gynecologists Women's Health Care Physicians; Committee on Health Care for Underserved Women. Committee opinion no. 570: breastfeeding in underserved women: increasing initiation and continuation of breastfeeding. Obstet Gynecol. 2013;1222 pt 1423–428.
    23. ACOG committee opinion no. 756: optimizing support for breastfeeding as part of obstetric practice. Obstet Gynecol. 2018;132:e187–e196.
    24. Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin no. 199: use of prophylactic antibiotics in labor and delivery. Obstet Gynecol. 2018;132:e103–e119.
    25. Society for Obstetric and Anesthesia and Perinatology. SOAP Enhanced Recovery after Cesarean Delivery Consensus Statement. Available at: Accessed May 5, 2020.
    26. Halperin JL, Levine GN, Al-Khatib SM, et al. Further evolution of the ACC/AHA clinical practice guideline recommendation classification system: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2016;133:1426–1428.
    27. Heesen M, Carvalho B, Carvalho JCA, et al. International consensus statement on the use of uterotonic agents during caesarean section. Anaesthesia. 2019;74:1305–1319.
    28. Purisch SE, Ananth CV, Arditi B, et al. Effect of delayed vs immediate umbilical cord clamping on maternal blood loss in term cesarean delivery: a randomized clinical trial. JAMA. 2019;322:1869–1876.
    29. Bauchat JR, Weiniger CF, Sultan P, et al. Society for obstetric anesthesia and perinatology consensus statement: monitoring recommendations for prevention and detection of respiratory depression associated with administration of neuraxial morphine for cesarean delivery analgesia. Anesth Analg. 2019;129:458–474.
    30. Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141:e419S–e496S.
    31. Hauk L. NPMS releases consensus statement on venous thromboembolism during pregnancy. Am Fam Physician. 2017;95:397–398.
    32. James A; Committee on Practice Bulletins—Obstetrics. Practice bulletin no. 123: thromboembolism in pregnancy. Obstet Gynecol. 2011;118:718–729.
    33. American College of Obstetricians; Gynecologists' Committee on Practice Bulletins—Obstetrics. ACOG practice bulletin no. 196: thromboembolism in pregnancy. Obstet Gynecol. 2018;132:e1–e17.
    34. World Health Organization. Ten Steps for Successful Breastfeeding. 2010. Available at: Accessed May 5, 2020.
    35. Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: an updated report by the American Society of Anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology. 2017;126:376–393.
    36. Carli F. Physiologic considerations of Enhanced Recovery After Surgery (ERAS) programs: implications of the stress response. Can J Anaesth. 2015;62:110–119.
    37. Thiele RH, Raghunathan K, Brudney CS, et al.; Perioperative Quality Initiative (POQI) I Workgroup. American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery. Perioper Med (Lond). 2016;5:24.
    38. Lim G, Facco FL, Nathan N, Waters JH, Wong CA, Eltzschig HK. A review of the impact of obstetric anesthesia on maternal and neonatal outcomes. Anesthesiology. 2018;129:192–215.
    39. Van de Putte P, Vernieuwe L, Perlas A. Term pregnant patients have similar gastric volume to non-pregnant females: a single-centre cohort study. Br J Anaesth. 2019;122:79–85.
    40. Chang CW, Shih SC, Wang HY, et al. Meta-analysis: the effect of patient education on bowel preparation for colonoscopy. Endosc Int Open. 2015;3:E646–E652.
    41. Claus D, Coudeyre E, Chazal J, Irthum B, Mulliez A, Givron P. An evidence-based information booklet helps reduce fear-avoidance beliefs after first-time discectomy for disc prolapse. Ann Phys Rehabil Med. 2017;60:68–73.
    42. Levinson W, Roter DL, Mullooly JP, Dull VT, Frankel RM. Physician-patient communication. The relationship with malpractice claims among primary care physicians and surgeons. JAMA. 1997;277:553–559.
    43. Love EM, Manalo IF, Chen SC, Chen KH, Stoff BK. A video-based educational pilot for basal cell carcinoma (BCC) treatment: a randomized controlled trial. J Am Acad Dermatol. 2016;74:477–483.e7.
    44. Ledford CJW, Sadler KP, Jackson JT, Womack JJ, Rider HA, Seehusen AB. Applying the chronic care model to prenatal care: patient activation, productive interactions, and prenatal outcomes. Patient Educ Couns. 2018;101:1620–1623.
    45. Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 2012;129:e827–e841.
    46. DiGirolamo AM, Grummer-Strawn LM, Fein SB. Effect of maternity-care practices on breastfeeding. Pediatrics. 2008;122(suppl 2):S43–S49.
    47. Hung KJ, Berg O. Early skin-to-skin after cesarean to improve breastfeeding. MCN Am J Matern Child Nurs. 2011;36:318–324.
    48. Moore ER, Bergman N, Anderson GC, Medley N. Early skin-to-skin contact for mothers and their healthy newborn infants. Cochrane Database Syst Rev. 2016;11:CD003519.
    49. Page-Goertz S, McCamman S, Westdahl C. Breastfeeding promotion. Top tips for motivating women to breastfeed their infants. AWHONN Lifelines. 2001;5:41–43.
    50. Centers for Disease Control and Prevention. About Breastfeeding. 2020. Available at: Accessed May 5, 2020.
    51. The Joint Commission. Speak Up: What You Need to Know About Breastfeeding. 2011. Available at: Accessed May 5, 2020.
    52. Lowe NK. The Surgeon General’s call to action to support breastfeeding. J Obstet Gynecol Neonatal Nurs. 2011;40:387–389.
    53. Centers for Disease Control and Prevention. Recommendations to prevent and control iron deficiency in the United States. MMWR Recomm Rep. 1998;47Rr-31–29.
    54. Althoff FC, Neb H, Herrmann E, et al. Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis. Ann Surg. 2019;269:794–804.
    55. Butwick AJ, Walsh EM, Kuzniewicz M, Li SX, Escobar GJ. Patterns and predictors of severe postpartum anemia after cesarean section. Transfusion. 2017;57:36–44.
    56. Sheikh M, Hantoushzadeh S, Shariat M, Farahani Z, Ebrahiminasab O. The efficacy of early iron supplementation on postpartum depression, a randomized double-blind placebo-controlled trial. Eur J Nutr. 2017;56:901–908.
    57. Sultan P, Bampoe S, Shah R, et al. Oral vs intravenous iron therapy for postpartum anemia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2019;221:19–29.e3.
    58. Kinsella SM, Carvalho B, Dyer RA, et al.; Consensus Statement Collaborators. International consensus statement on the management of hypotension with vasopressors during caesarean section under spinal anaesthesia. Anaesthesia. 2018;73:71–92.
    59. Akhtar Z, Hesler BD, Fiffick AN, et al. A randomized trial of prewarming on patient satisfaction and thermal comfort in outpatient surgery. J Clin Anesth. 2016;33:376–385.
    60. de Almeida MF, Guinsburg R, Sancho GA, et al.; Brazilian Network on Neonatal Research. Hypothermia and early neonatal mortality in preterm infants. J Pediatr. 2014;164:271–5.e1.
    61. Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N Engl J Med. 1996;334:1209–1215.
    62. Ousey K, Edward KL, Lui S, et al. Perioperative, local and systemic warming in surgical site infection: a systematic review and meta-analysis. J Wound Care. 2017;26:614–624.
    63. Sultan P, Habib AS, Cho Y, Carvalho B. The effect of patient warming during caesarean delivery on maternal and neonatal outcomes: a meta-analysis. Br J Anaesth. 2015;115:500–510.
    64. Sun Z, Honar H, Sessler DI, et al. Intraoperative core temperature patterns, transfusion requirement, and hospital duration in patients warmed with forced air. Anesthesiology. 2015;122:276–285.
    65. Duryea EL, Nelson DB, Wyckoff MH, et al. The impact of ambient operating room temperature on neonatal and maternal hypothermia and associated morbidities: a randomized controlled trial. Am J Obstet Gynecol. 2016;214:505.e1–505.e7.
    66. Dyer RA, van Dyk D, Dresner A. The use of uterotonic drugs during caesarean section. Int J Obstet Anesth. 2010;19:313–319.
    67. Kovacheva VP, Soens MA, Tsen LC. A randomized, double-blinded trial of a “rule of threes” algorithm versus continuous infusion of oxytocin during elective cesarean delivery. Anesthesiology. 2015;123:92–100.
    68. Lavoie A, McCarthy RJ, Wong CA. The ED90 of prophylactic oxytocin infusion after delivery of the placenta during cesarean delivery in laboring compared with nonlaboring women: an up-down sequential allocation dose-response study. Anesth Analg. 2015;121:159–164.
    69. Tita AT, Szychowski JM, Boggess K, et al.; C/SOAP Trial Consortium. Adjunctive azithromycin prophylaxis for cesarean delivery. N Engl J Med. 2016;375:1231–1241.
    70. Uppal V, Retter S, Casey M, Sancheti S, Matheson K, McKeen DM. Efficacy of intrathecal fentanyl for cesarean delivery: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. Anesth Analg. 2020;130:111–125.
    71. Dahlgren G, Hultstrand C, Jakobsson J, Norman M, Eriksson EW, Martin H. Intrathecal sufentanil, fentanyl, or placebo added to bupivacaine for cesarean section. Anesth Analg. 1997;85:1288–1293.
    72. Imeh A, Olaniyi O, Simeon O, Omotola O. Dexamethasone versus a combination of dexamethasone and ondansetron as prophylactic antiemetic in patients receiving intrathecal morphine for caesarean section. Afr Health Sci. 2014;14:453–459.
    73. Wu JI, Lo Y, Chia YY, et al. Prevention of postoperative nausea and vomiting after intrathecal morphine for cesarean section: a randomized comparison of dexamethasone, droperidol, and a combination. Int J Obstet Anesth. 2007;16:122–127.
    74. Demirhan A, Tekelioglu YU, Akkaya A, et al. Antiemetic effects of dexamethasone and ondansetron combination during cesarean sections under spinal anaesthesia. Afr Health Sci. 2013;13:475–482.
    75. Cardoso MM, Leite AO, Santos EA, Gozzani JL, Mathias LA. Effect of dexamethasone on prevention of postoperative nausea, vomiting and pain after caesarean section: a randomised, placebo-controlled, double-blind trial. Eur J Anaesthesiol. 2013;30:102–105.
    76. Eke AC, Shukr GH, Chaalan TT, Nashif SK, Eleje GU. Intra-abdominal saline irrigation at cesarean section: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2016;29:1588–1594.
    77. Viney R, Isaacs C, Chelmow D. Intra-abdominal irrigation at cesarean delivery: a randomized controlled trial. Obstet Gynecol. 2012;119:1106–1111.
    78. Mireault D, Loubert C, Drolet P, et al. Uterine exteriorization compared with in situ repair of hysterotomy after cesarean delivery: a randomized controlled trial. Obstet Gynecol. 2020;135:1145–1151.
    79. Coutinho IC, Ramos de Amorim MM, Katz L, Bandeira de Ferraz AA. Uterine exteriorization compared with in situ repair at cesarean delivery: a randomized controlled trial. Obstet Gynecol. 2008;111:639–647.
    80. El-Khayat W, Elsharkawi M, Hassan A. A randomized controlled trial of uterine exteriorization versus in situ repair of the uterine incision during cesarean delivery. Int J Gynaecol Obstet. 2014;127:163–166.
    81. Gode F, Okyay RE, Saatli B, Ertugrul C, Guclu S, Altunyurt S. Comparison of uterine exteriorization and in situ repair during cesarean sections. Arch Gynecol Obstet. 2012;285:1541–1545.
    82. Nafisi S. Influence of uterine exteriorization versus in situ repair on post-cesarean maternal pain: a randomized trial. Int J Obstet Anesth. 2007;16:135–138.
    83. Siddiqui M, Goldszmidt E, Fallah S, Kingdom J, Windrim R, Carvalho JC. Complications of exteriorized compared with in situ uterine repair at cesarean delivery under spinal anesthesia: a randomized controlled trial. Obstet Gynecol. 2007;110:570–575.
    84. Zaphiratos V, George RB, Boyd JC, Habib AS. Uterine exteriorization compared with in situ repair for cesarean delivery: a systematic review and meta-analysis. Can J Anaesth. 2015;62:1209–1220.
    85. Carvalho B, Butwick AJ. Postcesarean delivery analgesia. Best Pract Res Clin Anaesthesiol. 2017;31:69–79.
    86. Eandi M, Viano I, Ricci Gamalero S. Absolute bioavailability of paracetamol after oral or rectal administration in healthy volunteers. Arzneimittelforschung. 1984;34:903–907.
    87. Kollmann M, Aldrian L, Scheuchenegger A, et al. Early skin-to-skin contact after cesarean section: a randomized clinical pilot study. PLoS One. 2017;12:e0168783.
    88. Bergum D, Lonnée H, Hakli TF. Oxytocin infusion: acute hyponatraemia, seizures and coma. Acta Anaesthesiol Scand. 2009;53:826–827.
    89. Committee on Obstetric Practice. Committee opinion no. 684: delayed umbilical cord clamping after birth. Obstet Gynecol. 2017;129:e5–e10.
    90. Charoenkwan K, Phillipson G, Vutyavanich T. Early versus delayed (traditional) oral fluids and food for reducing complications after major abdominal gynaecologic surgery. Cochrane Database Syst Rev. 2007:Cd004508.
    91. Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology. 2015;123:1455–1472.
    92. Huang H, Wang H, He M. Early oral feeding compared with delayed oral feeding after cesarean section: a meta-analysis. J Matern Fetal Neonatal Med. 2016;29:423–429.
    93. Minig L, Biffi R, Zanagnolo V, et al. Reduction of postoperative complication rate with the use of early oral feeding in gynecologic oncologic patients undergoing a major surgery: a randomized controlled trial. Ann Surg Oncol. 2009;16:3101–3110.
    94. Minig L, Biffi R, Zanagnolo V, et al. Early oral versus “traditional” postoperative feeding in gynecologic oncology patients undergoing intestinal resection: a randomized controlled trial. Ann Surg Oncol. 2009;16:1660–1668.
    95. Schilder JM, Hurteau JA, Look KY, et al. A prospective controlled trial of early postoperative oral intake following major abdominal gynecologic surgery. Gynecol Oncol. 1997;67:235–240.
    96. D’Alton ME, Friedman AM, Smiley RM, et al. National partnership for maternal safety: consensus bundle on venous thromboembolism. Obstet Gynecol. 2016;128:688–698.
    97. Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg. 2002;183:630–641.
    98. Liebermann M, Awad M, Dejong M, Rivard C, Sinacore J, Brubaker L. Ambulation of hospitalized gynecologic surgical patients: a randomized controlled trial. Obstet Gynecol. 2013;121:533–537.
    99. van der Leeden M, Huijsmans R, Geleijn E, et al. Early enforced mobilisation following surgery for gastrointestinal cancer: feasibility and outcomes. Physiotherapy. 2016;102:103–110.
    100. Wijk L, Udumyan R, Pache B, et al. International validation of Enhanced Recovery After Surgery Society guidelines on enhanced recovery for gynecologic surgery. Am J Obstet Gynecol. 2019;221:237.e1–237.e11.
    101. ACOG committee opinion no. 766 summary: approaches to limit intervention during labor and birth. Obstet Gynecol. 2019;133:406–408.
    102. Ahmed MR, Sayed Ahmed WA, Atwa KA, Metwally L. Timing of urinary catheter removal after uncomplicated total abdominal hysterectomy: a prospective randomized trial. Eur J Obstet Gynecol Reprod Biol. 2014;176:60–63.
    103. Kuipers PW, Kamphuis ET, van Venrooij GE, et al. Intrathecal opioids and lower urinary tract function: a urodynamic evaluation. Anesthesiology. 2004;100:1497–1503.
    104. Phipps S, Lim YN, McClinton S, et al. Short term urinary catheter policies following urogenital surgery in adults. Cochrane Database Syst Rev. 2006:Cd004374.
    105. Walsh C, O’ Sullivan OE, Von Bunau G, Agnew G. Highlights of 38th annual IUGA meeting with the Continence Foundation of Ireland, Dublin, Ireland, 2013. Int Urogynecol J. 2013;24:1993–1994.
    106. Friedman AM, D’Alton ME. Venous thromboembolism bundle: risk assessment and prophylaxis for obstetric patients. Semin Perinatol. 2016;40:87–92.
    107. Ferguson S, Davis D, Browne J. Does antenatal education affect labour and birth? A structured review of the literature. Women Birth. 2013;26:e5–e8.
    108. Chandrasekaran N, De Souza LR, Urquia ML, et al. Is anemia an independent risk factor for postpartum depression in women who have a cesarean section? - A prospective observational study. BMC Pregnancy Childbirth. 2018;18:400.
    109. Kang SY, Kim HB, Sunwoo S. Association between anemia and maternal depression: a systematic review and meta-analysis. J Psychiatr Res. 2020;122:88–96.
    110. Eckerdal P, Kollia N, Löfblad J, et al. Delineating the association between heavy postpartum haemorrhage and postpartum depression. PLoS One. 2016;11:e0144274.
    111. Thurn L, Wikman A, Westgren M, Lindqvist PG. Incidence and risk factors of transfusion reactions in postpartum blood transfusions. Blood Adv. 2019;3:2298–2306.
    112. Snell P, Hicks C. An exploratory study in the UK of the effectiveness of three different pain management regimens for post-caesarean section women. Midwifery. 2006;22:249–261.
    113. American Society of Anesthesiologists Task Force on Obstetric Anesthesia. Practice guidelines for obstetric anesthesia: an updated report by the American Society of Anesthesiologists Task Force on Obstetric Anesthesia. Anesthesiology. 2007;106:843–863.
    114. Elia N, Lysakowski C, Tramèr MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology. 2005;103:1296–1304.
    115. Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth. 2011;106:292–297.
    116. Berger JS, Gonzalez A, Hopkins A, et al. Dose-response of intrathecal morphine when administered with intravenous ketorolac for post-cesarean analgesia: a two-center, prospective, randomized, blinded trial. Int J Obstet Anesth. 2016;28:3–11.
    117. Blackburn A, Stevens JD, Wheatley RG, Madej TH, Hunter D. Balanced analgesia with intravenous ketorolac and patient-controlled morphine following lower abdominal surgery. J Clin Anesth. 1995;7:103–108.
    118. Niruthisard S, Werawataganon T, Bunburaphong P, Ussawanophakiat M, Wongsakornchaikul C, Toleb K. Improving the analgesic efficacy of intrathecal morphine with parecoxib after total abdominal hysterectomy. Anesth Analg. 2007;105:822–824.
    119. Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110:1170–1179.
    120. Kiran RP, Turina M, Hammel J, Fazio V. The clinical significance of an elevated postoperative glucose value in nondiabetic patients after colorectal surgery: evidence for the need for tight glucose control? Ann Surg. 2013;258:599–604.
    121. Qaseem A, Humphrey LL, Chou R, Snow V, Shekelle P; Clinical Guidelines Committee of the American College of Physicians. Use of intensive insulin therapy for the management of glycemic control in hospitalized patients: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2011;154:260–267.
    122. Ramos M, Khalpey Z, Lipsitz S, et al. Relationship of perioperative hyperglycemia and postoperative infections in patients who undergo general and vascular surgery. Ann Surg. 2008;248:585–591.
    123. Sultan P, Sharawi N, Blake L, Carvalho B. Enhanced recovery after caesarean delivery versus standard care studies: a systematic review of interventions and outcomes. Int J Obstet Anesth. 2020;43:72–86.
    Copyright © 2020 International Anesthesia Research Society