In this issue of Anesthesia & Analgesia, Driver et al perform a post hoc analysis of a subset of patients from the PRODIGY trial to determine the incidence, frequency, and temporal distribution of respiratory depression after surgery. They specifically observed the peak time frame in which the initial respiratory depression episodes occurred as well as the highest likelihood of when all respiratory depression episodes would eventuate. As seen in this infographic, patients displayed the initial event mostly between 2 pm and 8 pm on the day of surgery. All respiratory depression events were mostly likely to occur between 2 am and 6 am This study has important implications on defining how best to monitor postsurgical patients with scrutiny during the most at-risk time frames.
1. Driver CN, Laporta ML, Bergese SD, et al. Frequency and temporal distribution of postoperative respiratory depressive events. Anesth Analg. 2021132:1206–1214.
2. Khanna AK, Bergese SD, Jungquist CR, et al. Prediction of opioid-induced respiratory depression on inpatient wards using continuous capnography and oximetry: an international, prospective, observational trial. Prediction of opioid-induced respiratory depression on inpatient wards using continuous capnography and oximetry: an international prospective, observational trial. Anesth Analg. 2020;131:1012–1024.