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Featured Articles: Infographic

New Tools in the Tool Belt: Basic Science Research Updates for Anesthesia

Wanderer, Jonathan P. MD, MPhil; Nathan, Naveen MD

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doi: 10.1213/ANE.0000000000004997
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The advent of revolutionary basic science research techniques has radically transformed the possibilities for understanding and modifying fundamental cellular processes. Specifically, advances in genetic sequencing have dramatically reduced the cost of elucidating cellular programming, application of transcription factors has made it feasible to develop pluripotent stem cells from somatic sources, and novel approaches have lowered the barrier for performing effective and efficient genetic editing. In this infographic, we review the technologies of next-generation sequencing, inducible pluripotent stem cells, and clustered regularly interspaced short palindromic repeat modulations and describe their applications in anesthesiology.

NGS indicates next-generation sequencing.


1. Obal D, Wu S, McKinstry-Wu A, Tawfik VLA guide to understanding “State-of-the-Art” basic research techniques in anesthesiology. Anesth Analg. 2020;131:450–463.
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