Featured Articles: Infographic
New Tools in the Tool Belt: Basic Science Research Updates for Anesthesia
Wanderer, Jonathan P. MD, MPhil; Nathan, Naveen MD
Author Information
Vanderbilt University School of Medicine (jon.wanderer@vanderbilt.edu)
Northwestern University Feinberg School of Medicine (n-nathan@northwestern.edu).
The Infographic is composed by Jonathan P. Wanderer, MD, MPhil, Vanderbilt University School of Medicine (jon.wanderer@vanderbilt.edu), and Naveen Nathan, MD, Northwestern University Feinberg School of Medicine (n-nathan@northwestern.edu). Illustration by Naveen Nathan, MD.
The authors declare no conflicts of interest.
doi: 10.1213/ANE.0000000000004997
The advent of revolutionary basic science research techniques has radically transformed the possibilities for understanding and modifying fundamental cellular processes. Specifically, advances in genetic sequencing have dramatically reduced the cost of elucidating cellular programming, application of transcription factors has made it feasible to develop pluripotent stem cells from somatic sources, and novel approaches have lowered the barrier for performing effective and efficient genetic editing. In this infographic, we review the technologies of next-generation sequencing, inducible pluripotent stem cells, and clustered regularly interspaced short palindromic repeat modulations and describe their applications in anesthesiology.
NGS indicates next-generation sequencing.
REFERENCES
1. Obal D, Wu S, McKinstry-Wu A, Tawfik VLA guide to understanding “State-of-the-Art” basic research techniques in anesthesiology. Anesth Analg. 2020;131:450–463.
