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Featured Articles: Infographic

Sugammadex: Now With Fewer Complications!

Wanderer, Jonathan P. MD, MPhil; Nathan, Naveen MD

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doi: 10.1213/ANE.0000000000004896
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Postoperative residual neuromuscular blockade is known to predispose surgical patients to adverse respiratory physiology, specifically through impairing upper airway dilator muscles, increasing odds of airway obstruction, and interfering with swallowing. Neostigmine is an agent used to reverse neuromuscular blockade but can cause similar effects when not dosed appropriately. In this infographic, we review a postoperative respiratory failure outcome study that analyzes the transition from neostigmine to sugammadex at one institution, demonstrating a reduction in the incidence of postoperative respiratory failure after adjusting for confounding factors.

CI indicates confidence interval; ICU, intensive care unit.

REFERENCES

1. Togioka BM, Xinling X, Banner-Goodspeed V, Eikermann M. Does sugammadex reduce postoperative airway failure? Anesth Analg. 2020;131:137–140.
2. Krause M, McWilliams SK, Bullard KJ, et al. Neostigmine versus sugammadex for reversal of neuromuscular blockade and effects on reintubation for respiratory failure or newly initiated non-invasive ventilation: an interrupted time series study design. Anesth Analg. 2020;131:141–151.
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