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Inflamed in the Membrane: Neuroinflammation and Perioperative Neurocognitive Disorders

Nathan, Naveen MD

doi: 10.1213/ANE.0000000000004098
Infographics: Infographic

Northwestern University Feinberg School of Medicine (

Published ahead of print 24 January 2019.

The Infographic is composed by Naveen Nathan, MD, Northwestern University Feinberg School of Medicine ( Illustration by Naveen Nathan, MD.

The author declares no conflicts of interest.

This infographic offers a visual summary of how patient comorbidities, surgical stress, and anesthetic technique convene in the development of both systemic and neurologic inflammation. The latter has been observed through the listed biomarkers as well as imaging studies. Terrando and Subramaniyan describe how current science defines the role of neurologic inflammation in the predisposition to perioperative neurocognitive dysfunction. For a full scope and understanding of this subject, the reader is strongly encouraged to review the referenced article.

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1. Terrando N, Subramaniyan S. Neuroinflammation and perioperative neurocognitive disorders. Anesth Analg. 2019;128:781–788.
Copyright © 2019 International Anesthesia Research Society