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Impact on the Frontlines

Anesthetic Effects on Neutrophil Function

Nathan, Naveen, MD

doi: 10.1213/ANE.0000000000004040
Infographics: Infographic
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SDC

Northwestern University Feinberg School of Medicine (n-nathan@northwestern.edu).

Published ahead of print 26 December 2018.

The Infographic is composed by Naveen Nathan, MD, Northwestern University Feinberg School of Medicine (n-nathan@northwestern.edu). Illustration by Naveen Nathan, MD.

The author declares no conflicts of interest.

Figure

Figure

The infographic summarizes the purported effects of commonly used anesthetic drugs on neutrophil function as is described in this issue by Meier and Nizet.1 Anesthetic drugs variably influence cell receptors that govern neutrophil rolling, adhesion, chemotaxis, and the actual act of bacterial killing. As neutrophils play a key role in both inflammation as well as protection against pathogenic invaders, it remains to be seen how anesthetic pharmacology tips the balance variably in either direction. The reader is encouraged to review the corresponding article for a deeper understanding of cellular and molecular responses.

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REFERENCES

1. Meier A, Nizet V. Impact of anesthetics on human neutrophil function. Anesth Analg. 2019; 128:569–574.
© 2019 International Anesthesia Research Society