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Factor XI Deficiency and Pregnancy: Abnormal Lab Values or Significant Risk?

Wanderer, Jonathan P. MD, MPhil; Nathan, Naveen MD

doi: 10.1213/ANE.0000000000003501
Infographics: Infographic

Vanderbilt University School of Medicine (

Northwestern University Feinberg School of Medicine (

The Infographic is composed by Jonathan P. Wanderer, MD, MPhil, Vanderbilt University School of Medicine (, and Naveen Nathan, MD, Northwestern University Feinberg School of Medicine ( Illustration by Naveen Nathan, MD.

The authors declare no conflicts of interest.

The management of parturients with coagulopathy involves a careful assessment of risks and benefits to determine the most appropriate plan for workup and management. Pregnant patients with factor XI deficiency present a particularly complex scenario because frequently their diagnosis is revealed through laboratory testing and the clinical implications are unclear. In this infographic, we will review the normal function of factor XI, how to evaluate factor levels in the context of clinical history, and management strategies in the setting of pregnancy.

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1. Shander A, Friedman T, Palleschi G, Shore-Lesserson LThe evolving dilemma of factor XI in pregnancy: suggestions for management. Anesth Analg. 2018;126:2032–2037.
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