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Post-Cardiac Arrest Management: Time to Cool It on Cooling?

Wanderer, Jonathan P. MD, MPhil; Nathan, Naveen MD

doi: 10.1213/ANE.0000000000002832
Infographics: Infographic

Vanderbilt University School of Medicine (

Northwestern University Feinberg School of Medicine (

The Infographic is composed by Jonathan P. Wanderer, MD, MPhil, Vanderbilt University School of Medicine (, and Naveen Nathan, MD, Northwestern University Feinberg School of Medicine ( Illustration by Naveen Nathan, MD.

The authors declare no conflicts of interest.

Therapeutic hypothermia after postcardiac arrest has become a recommended component of care for survivors. Despite this recommendation, recent randomized clinical trials have failed to support the benefit of targeted temperature management on important end points such as all-cause mortality and neurological outcomes. In this infographic, we review the timeline of the development of the current recommendations, visualize the clinical trials that have provided data to guide clinical care, and summarize a recent meta-analysis that synthesizes the high-quality data available to date.

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1. Kalra R, Arora G, Patel N, et al. Targeted temperature management after cardiac arrest: systematic review and meta-analyses. Anesth Analg. 2018126:867–875.
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