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Infographics: Infographic

Subcellular Hypoxia: A Survival Guide

Wanderer, Jonathan P. MD, MPhil; Nathan, Naveen MD

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doi: 10.1213/ANE.0000000000002166
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While the delivery of oxygen to tissue is essential for aerobic metabolism and life, hypoxia is an essential aspect of embryogenesis in mammals and many species tolerate prolonged periods of decreased metabolism and access to oxygen. These adaptations have implications for diseases such as cancer and sepsis. In this infographic, we review several key aspects of adaptations for hypoxia and describe therapeutic implications.1,2


1. Thiele RH. Subcellular energetics and metabolism: a cross-species framework. Anesth Analg. 2017;124:1857–1871.
2. Thiele RH. Subcellular energetics and metabolism: potential therapeutic applications. Anesth Analg. 2017;124:1872–1885.
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