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Subcellular Hypoxia

A Survival Guide

Wanderer, Jonathan P., MD, MPhil; Nathan, Naveen, MD

doi: 10.1213/ANE.0000000000002166
Infographics: Infographic
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Vanderbilt University School of Medicine (jon.wanderer@vanderbilt.edu)

Northwestern University Feinberg School of Medicine (n-nathan@northwestern.edu)

The Infographic is composed by Jonathan P. Wanderer, MD, MPhil, Vanderbilt University School of Medicine (jon.wanderer@vanderbilt.edu), and Naveen Nathan, MD, Northwestern University Feinberg School of Medicine (n-nathan@northwestern.edu). Illustration by Naveen Nathan, MD.

The authors declare no conflicts of interest.

Figure

Figure

While the delivery of oxygen to tissue is essential for aerobic metabolism and life, hypoxia is an essential aspect of embryogenesis in mammals and many species tolerate prolonged periods of decreased metabolism and access to oxygen. These adaptations have implications for diseases such as cancer and sepsis. In this infographic, we review several key aspects of adaptations for hypoxia and describe therapeutic implications.1,2

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REFERENCES

1. Thiele RH. Subcellular energetics and metabolism: a cross-species framework. Anesth Analg. 2017;124:1857–1871.
2. Thiele RH. Subcellular energetics and metabolism: potential therapeutic applications. Anesth Analg. 2017;124:1872–1885.
© 2017 International Anesthesia Research Society