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Left Main Coronary Artery Dissection During Aortic Valve Replacement

Nakao, Kenta MD*; Sawai, Toshiyuki MD, PhD*; Nakahira, Junko MD, PhD*; Hamakawa, Ayako MD; Ishii, Hisanari MD, PhD; Minami, Toshiaki MD, PhD*

doi: 10.1213/ANE.0000000000002064
Perioperative Echocardiography and Cardiovascular Education

From the *Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan; and Department of Anesthesiology, Tenri Hospital, Tenri, Japan.

Accepted for publication December 22, 2016.

Funding: None.

The authors declare no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website.

Reprints will not be available from the authors.

Address correspondence to Toshiyuki Sawai, MD, PhD, Department of Anesthesiology, Osaka Medical College, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, Japan. Address e-mail to

A 73-year-old man was scheduled to undergo aortic valve replacement (AVR) for severe aortic stenosis. Transthoracic echocardiography showed normal left ventricular function with no regional wall motion abnormalities (RWMA). Preoperative coronary artery angiography showed no significant stenosis. Written informed consent was obtained from the patient for publication of this report.

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Figure 1.

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Figure 3.

Transesophageal echocardiography (TEE) before initiating cardiopulmonary bypass (CPB) showed no additional findings compared with preoperative transthoracic echocardiography. During CPB, myocardial protection was achieved by antegrade (via the ascending aorta) and retrograde (via the coronary sinus) administration of cardioplegia. The aortic root was markedly calcified. After removal of calcification, the aortic valve was replaced with a bio-prosthesis. After aortic cross-clamp release, normal function of the prosthetic valve was confirmed. However, during weaning off CPB, a localized linear density was observed in the proximal left main coronary artery in the short-axis view of the midesophageal (ME) aortic valve (Figure 1; Supplemental Digital Content, Video 1, This linear density suggested a coronary artery dissection flap. No aortic root dissection was detected. In the short-axis view of the modified ME aortic valve, coronary blood flow velocity was measured by pulsed wave (PW) Doppler and showed a marked increase in diastole (1.4 m/s), which suggested coronary artery stenosis (Figure 2). Neither RWMA by TEE nor ischemia-related changes by electrocardiogram in perfusion territories of the left main coronary artery were observed. Therefore, we elected to continue weaning from CPB and perform coronary artery angiography postoperatively. Weaning from CPB was performed without difficulty, and surgery was completed with stable hemodynamics. Postoperative coronary artery angiography showed 75% stenosis in the left main coronary artery. Optical coherence tomography, a catheter-based invasive imaging system for clearly visualizing lumen morphology, showed a localized dissection (Figure 3). A drug-eluting stent was placed at the dissection site of the left main coronary artery. The patient was discharged, and the clinical course did not show any hemodynamic changes.

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Coronary artery dissection is spontaneous or iatrogenic (Table).1–3 Iatrogenic coronary artery dissection results from catheters during percutaneous coronary intervention or cardioplegia administration, or handling during surgical procedures, such as implantation of the coronary ostia during aortic root surgery.2,3 Spontaneous coronary artery dissection typically follows aortic dissection, or it is caused by atherosclerosis, hypertension, coronary vasospasm, or pregnancy and may occur in connective tissue diseases.4 Aortic dissection can extend to a coronary artery, and it involves the right coronary artery, typically.5 In our case, there was neither an ascending aorta nor right coronary artery dissection. Additionally, the coronary artery ostia were not directly cannulated as intraoperative myocardial protection was achieved using antegrade and retrograde administration of cardioplegia. We speculate that the cause of dissection was an intimal tear at the ostium of the left main coronary artery when calcification of the aortic root was removed.



This case presented a considerable challenge in decision making regarding the treatment strategy. Although TEE is useful for diagnosing coronary artery ostial dissection, detailed assessment of the coronary artery lumen, progression of dissection, or the number of affected branches is difficult.6 Following AVR, an intracoronary mass should be differentiated from ultrasound artifacts as well as an intimal flap, suture material, and calcified debris. A dissection flap has a similar echogenicity to the wall of a coronary artery and does not cross physical boundaries. On the other hand, masses, such as retained sutures or calcified debris, appear highly echogeneic.7

Measurement of coronary blood flow velocity with TEE is challenging because it is difficult to position the PW Doppler sample volume inside the moving coronary artery. The diagnostic accuracy of PW Doppler is improved by using a lower frequency transducer and scanning at a decreased depth, in order to increase the pulse repetition frequency, parallel alignment with blood flow, and proper setting of the velocity scale. To obtain more accurate findings, epicardial ultrasound imaging might help in the definitive diagnosis. Stenosis of the left main coronary artery should be suspected if coronary blood flow velocity is increased above the normal range of 0.3–0.4 m/s.8

If new RWMA consistent with left main coronary artery perfusion zones appear intraoperatively, surgical revascularization should be undertaken without hesitation.

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Clinician’s Key Teaching Points

By Kent H. Rehfeldt, MD, and Nikolaos J. Skubas, MD

  1. Coronary artery dissection is an iatrogenic complication or occurs spontaneously. Percutaneous interventions, direct administration of cardioplegia into the coronary ostia, or surgical manipulation of the aortic root are the most frequent iatrogenic causes. Coronary artery dissection can occur spontaneously from retrograde progression of aortic dissection or in the setting of hypertension, pregnancy, or coronary vasospasm.
  2. Echocardiographic features consistent with coronary artery dissection include the visualization of a linear density within the coronary lumen. Additionally, the dissection flap can elevate blood flow velocities above the normal range of 0.3–0.4 m/s. The finding of new RWMA in the corresponding myocardial territory is suggestive of an acute reduction in coronary blood flow.
  3. In this case, a linear density, suspicious for a dissection flap, was observed by TEE (short-axis view of the ME aortic valve) in the left main coronary artery lumen following aortic root decalcification and AVR. Additionally, the diastolic flow velocity in the left main coronary artery was increased to 0.7 m/s. However, given the absence of associated RWMA, the lack of ascending aorta dissection, and the hemodynamic stability of the patient, the operation was completed and the patient was transferred to the catheterization laboratory where the diagnosis of left main coronary dissection was confirmed and treated by stent placement.
  4. Coronary artery dissection should be distinguished from other causes of echogenic material within the vessel lumen. A dissection flap has an echo density similar to that of the coronary artery wall and does not cross anatomic boundaries. Sutures or calcified debris display an increased echo density compared with a dissection flap, whereas artifacts may extend beyond the coronary lumen.
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We appreciate Dr Yoshihiro Takeda for the assessment.

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Name: Kenta Nakao, MD.

Contribution: This author was in charge of the patient and helped prepare the manuscript.

Name: Toshiyuki Sawai, MD, PhD.

Contribution: This author helped manage the manuscript, figures, video, and table.

Name: Junko Nakahira, MD, PhD.

Contribution: This author helped prepare the figures and the video.

Name: Ayako Hamakawa, MD.

Contribution: This author helped prepare the references.

Name: Hisanari Ishii, MD, PhD.

Contribution: This author was in charge of the patient and helped prepare the manuscript.

Name: Toshiaki Minami, MD, PhD.

Contribution: This author helped perform a native check.

This manuscript was handled by: Nikolaos J. Skubas, MD, DSc, FACC, FASE.

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1. Jorgensen MB, Aharonian V, Mansukhani P, Mahrer PR. Spontaneous coronary dissection: a cluster of cases with this rare finding. Am Heart J. 1994;127:1382–1387
2. Michalak KW, Moszura T, Peruga JZ, Moll JJ. Right coronary artery dissection during intraoperative ostium cannulation. Presentation of successful treatment. Kardiol Pol. 2011;69:966–968
3. Machado Fde P, Sampaio RO, Mazzucato FL, Tarasoutchi F, Spina GS, Grinberg M. Acute coronary artery dissection after aortic valve replacement. Arq Bras Cardiol. 2010;94:e23–e25, e82–e85, e31–e34
4. Yip A, Saw J. Spontaneous coronary artery dissection—a review. Cardiovasc Diagn Ther. 2015;5:37–48
5. Kawahito K, Adachi H, Murata S, Yamaguchi A, Ino T. Coronary malperfusion due to type A aortic dissection: mechanism and surgical management. Ann Thorac Surg. 2003;76:1471–1476
6. Lerakis S, Manoukian S, Martin RP. Transesophageal echo detection of postpartum coronary artery dissection. J Am Soc Echocardiogr. 2001;14:1132–1133
7. Spence BC, Hartman GS. Mass in the left main coronary artery after aortic valve replacement. Anesth Analg. 2011;112:535–537
8. Cortigiani L, Rigo F, Gherardi S, Bovenzi F, Picano E, Sicari R. Prognostic value of Doppler echocardiographic-derived coronary flow velocity reserve of left anterior descending artery in octogenarians with stress echocardiography negative for wall motion criteria. Eur Heart J Cardiovasc Imaging. 2015;16:653–660

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