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Perioperative Precision Medicine

Promise, Progress, and Pitfalls

Wanderer, Jonathan P., MD, MPhil; Nathan, Naveen, MD

doi: 10.1213/ANE.0000000000002009
Infographics: Infographic

Vanderbilt University School of Medicine (

Northwestern University Feinberg School of Medicine (

The Infographic is composed by Jonathan P. Wanderer, MD, MPhil, Vanderbilt University School of Medicine (, and Naveen Nathan, MD, Northwestern University Feinberg School of Medicine (

Illustration by Naveen Nathan, MD.

The authors declare no conflicts of interest.



The promise of perioperative precision medicine is the ability to make drug and dosage choices that are informed by each patient’s genomic data. While substantial progress towards understanding drug-genome interactions has been made, large gaps exist between current state and fulfillment of precision medicine’s potential. In this infographic, we describe the relevant perioperative genomic interactions, and demonstrate some of the current limitations for this approach.1,2

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1. Iravani M, Lee LK, Cannesson M. Standardized Care versus precision medicine in the perioperative setting: can point-of-care testing help bridge the gap? Anesth Analg. 2017;124:1347–1353.
© 2017 International Anesthesia Research Society