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Editor’s Note: Notice of Retraction

Shafer, Steven L. MD

doi: 10.1213/ANE.0000000000000417
Retraction: Retraction

Editor-in-Chief, Anesthesia & Analgesia

In 2009, Joachim Boldt published an article in Anesthesia & Analgesia comparing albumin and hydroxyethyl starch priming cardiopulmonary bypass.1 The study was retracted in December 2010 for lack of IRB approval.2 A subsequent investigation by Klinikum Ludwigshafen determined that the study was fabricated.3

Based on the finding by Landesärztekammer Rheinland-Pfalz, the State Medical Association of Rheinland-Pfalz that the studies were conducted without IRB approval, Anesthesia & Analgesia retracted 22 papers by Dr. Boldt in 2011 for unethical conduct of research.4 A subsequent investigation by Klinikum Ludwigshafen found that Boldt’s studies “failed to meet required standards,” included “false data” in at least 10 studies, and found “clear evidence of procedural irregularities and research misconduct on the part of Dr. Joachim Boldt.”

In light of these concerns, Justus-Liebig Universität Giessen undertook an investigation of Dr. Boldt’s work from that institution. This investigation cast doubt on the veracity of Boldt J, Heesen M, Müller M, Pabsdorf M, Hempelmann G. The effects of albumin versus hydroxyethyl starch solution on cardiorespiratory and circulatory variables in critically ill patient. Anesth Analg 1996;83:254–61. Based on evidence of data manipulation reported by Justus-Liebig Universität Giessen to the journal, this paper is hereby retracted.

Steven L. Shafer, MD


Anesthesia & Analgesia

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1. Boldt J, Suttner S, Brosch C, Lehmann A, Röhm K, Mengistu A. Cardiopulmonary bypass priming using a high dose of a balanced hydroxyethyl starch versus an albumin-based priming strategy. Anesth Analg. 2009;109:1752–62
2. Shafer SL. Notice of retraction. Anesth Analg. 2010;111:1567
3. Shafer SL. Shadow of doubt. Anesth Analg. 2011;112:498–500
4. Shafer SL. Notice of retraction Anesth Analg. 2011:1246–7
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