The patients' discomfort scores during PEAE were decreased as compared with their previous office-based examination (2.5 vs 4.9, P < 0.05).
In 114 of 138 cases, the PEAE procedure was completed before the OR had been readied for the surgical procedure. In the remaining 24 cases, PEAE delayed room entry by no more than 3 minutes.
At no time during this study was an emergent airway situation encountered. All tracheal intubations were accomplished in accordance with the PEAE plan, without episodes of oxyhemoglobin desaturation or need to change the recorded airway device.
The search for anatomic correlates and causes of difficult tracheal intubation has historically focused on findings associated with the failure of DL. As techniques of glottic visualization evolve (e.g., with the incorporation of indirect imaging technology), traditional airway measures or indexes may become less important to airway management practice.6 But despite the success of these newer instruments in situations in which DL has, or is predicted to fail, pathology in the “invisible” upper airway (i.e., at and below the level of the oral pharynx) may impede successful airway control with any instrument. Although many patients with known airway lesions will eventually be managed with routine anesthetic induction, the uncertain architecture of their airway anatomy, and therefore the potential for a catastrophic outcome, should infer an airway failure risk when they are initially evaluated.3 According to the American Society for Anesthesiologists' Task Force on the Difficult Airway, AI should be considered in these cases.2 Obviously, AI techniques in all patients who harbor an undefined risk for obstruction would unnecessarily draw on resources (equipment, personnel, and OR time), and cause discomfort in some patients. This would be especially disruptive in the ambulatory surgery setting, where a large number of patients may present for short diagnostic procedures of the upper airway.
Flexible nasal-endoscopy is a procedure frequently performed by otolaryngologists during a presurgical evaluation and may be accomplished with little or no patient preparation, monitoring, or discomfort.7 Unfortunately, the report of the otolaryngologist's preoperative examination may be inadequate for use by the anesthesiologists: the presurgical evaluation may have occurred weeks before the OR visit, and a rapidly changing lesion may become a previously unappreciated obstacle. Additionally, the otolaryngologist might not consider the anesthesiologist's use of supraglottic ventilation, or DL and indirect laryngoscopy techniques of tracheal intubation.
Because flexible indirect laryngoscopic examination of the upper airway is a technique familiar to the anesthesiologist, and the equipment is widely available, we sought to evaluate the clinical impact of PEAE on airway management decisions in the otolaryngology patient.1,4,7 When approached as a diagnostic (as opposed to a therapeutic) maneuver, airway endoscopy can be performed rapidly and requires little or no patient preparation.7 Moorthy et al.1 incorporated routine endoscopy into their examination of patients presenting with upper airway pathology over a 10-year period. Although these clinicians reviewed historical, physical examination, imaging, and other laboratory information, their airway management plan was also influenced by the PEAE. In the current study, we sought to determine whether PEAE would cause a change in the airway management plan that had been devised based on standard evaluation techniques alone. Although often available, pulmonary function tests and advanced radiological imaging were not used in our study design for 3 reasons. First, this information was not universally available at the time of our patients' presentations. Second, static imaging does not reflect changes in anatomic relationships with spontaneous ventilation, positive pressure ventilation, or the onset of anesthesia. Third, pulmonary function tests (that are obtained during spontaneous ventilation) may not reflect airway restriction caused by complex, fixed, and dynamic lesions when managed with positive pressure ventilation.
PEAE was performed to evaluate 3 anatomic findings that could not be assessed by standard airway examination. Although failure to find an optically straightforward access to the larynx does not exclude intubation success with a rigid or flexible device, it does discourage routine anesthetic induction; in the event of facemask or SGA ventilation failure, rapid tracheal tube placement cannot be relied on for airway salvage. Anatomic lesions that might interfere with SGA placement (e.g., posterior pharyngeal or upper esophageal masses) reduce the likelihood of success when using these devices in the event that other means of controlling the airway fail; in patients with preoperative findings consistent with difficult laryngeal visualization (e.g., significant standard airway examination findings, a history of upper airway surgery, or radiation), the additional identification of intra-airway lesions that cast doubt on successful SGA placement should discourage the induction of anesthesia before airway control, lest SGA salvage be needed. Lastly, vascular or friable lesions situated on the anterior surfaces of the upper airway may limit the use of devices that apply direct pressure (e.g., DL/VL) to these tissues, and therefore deter the inclusion of these instruments in a plan for rapid airway salvage after failed facemask or SGA ventilation.
In the current trial, PEAE led to a change in the airway management plan in one-quarter of the patients. The occurrence of a plan change was statistically significant when the Clinical decision plan called for AI, thereby reducing the use of awake techniques (P < 0.05). As noted, the site of airway pathology did not affect the post-PEAE change of plan. Additionally, 8 of 94 patients whose initial, clinically based plan called for tracheal intubation after the induction of anesthesia underwent AI after PEAE (P < 0.05). This group represents those whom PEAE served best: patients whose standard airway examination led the clinician to choose anesthetic induction before securing the airway, yet were discovered to have unexpectedly significant pathology on endoscopic examination. Clinical signs, symptoms, or standard airway examination findings did not make manifest the severity of their airway disease. It is speculated that had routine anesthetic induction been pursued, some of these patients' tracheas may have been both impossible to intubate and/or to ventilate by any means and might have required invasive airway rescue. No patients in the current study required emergency invasive airway management or were allowed to awaken because of airway management failure.
Conversely, 28 of the 44 patients for whom the standard airway examination resulted in an initial choice of AI underwent routine induction and intubation after PEAE. This included 2 distinct patient groups: those patients with unremarkable standard airway examinations, but with a history or symptoms that caused a suspicion of significant airway pathology, and those patients with clinical findings consistent with difficult laryngoscopy and/or difficult ventilation (e.g., history of radiation or surgery, small interincisor gap, higher Samsoon and Young score). After the attending anesthesiologist was reassured by PEAE that the “invisible” airway was not obstructed or included other pathology of concern, routine induction was pursued. This represented a 54% reduction in all AI events.
For the purposes of the study, the attending anesthesiologist was limited in the choice of tracheal intubation devices. Although the nonsurgical intubation armamentarium of the modern OR is vast compared with just a decade ago, it can be described by 2 basic device designs: sagittal plane line-of-sight devices (e.g., DL, VL, channeled laryngoscopes, optical stylets, blind intubation devices), or multiplane line-of-sight devices (e.g., flexible fiberoptic laryngoscopes, flexible digital scopes). In obstructive or complex lesions of the upper airway, devices that can be manipulated in more than a single plane may be able to follow a pathway to the larynx that has been distorted out of the simple sagittal plane. Because this is often the most significant change to affect access to the airway, we decided to limit the choice of intubation devices. In 1 patient, these options were too limiting for the attending anesthesiologist, who opted for a minimally invasive technique (i.e., retrograde wire-aided intubation) because of severe airway distortion. This patient's data remained in the analysis because, in the context of the current study, his airway represented an extreme form of nonsagittal plane airway distortion.
In our series of patients, clinical signs of airway compromise were not helpful, and at times were misleading in identifying those who were eventually managed with AI. Of 10 patients with voice changes or stridor who were judged on standard airway examination to require AI (Clinical decision-Awake), 5 were changed to the PEAE-Induced plan after endoscopy. Likewise, of the 8 Clinical decision-Induced patients who were changed to PEAE-Awake management after endoscopy, 5 had no clinical signs of airway compromise. Whereas patients who were moved from the Clinical decision-Awake to the PEAE-Induced group represent a reduction in unnecessary AIs, these latter patients underscore the diagnostic advantage of endoscopic evaluation: patients without manifest signs of airway compromise, yet harboring potentially obstructive lesions, were identified only through PEAE.
In each case in which AI was chosen based on the PEAE findings, the outcome, had intubation after induction been pursued clinically, is unknown. Determining which PEAE findings mandate AI would have necessitated blinding the attending anesthesiologist to the results of the endoscopy, which the authors believed was ethically unfeasible. Another limiting aspect of this protocol was that the same clinician was responsible for determining both the Clinical decision plan and PEAE plan. An attempt to mitigate this potential bias was made with the remote reevaluation of the PEAE recordings; the clinical history and video records were reviewed ≥4 months after the first data collection. The remote PEAE plans did not differ significantly from the original, PEAE plans results.
Although our data suggest that PEAE may efficiently provide the practitioner with superior information to be used in managing the patient with a difficult airway, the potential for bias can not be fully eliminated without the performance of a randomized controlled trial. A true randomized controlled trial could not only verify whether PEAE reduces the use of AI, but also weigh the benefits of performing PEAE in all patients versus the modest occurrence of unnecessary AI in some.
PEAE is a noninvasive technique that may be completed without OR delay. Unlike AI, only the nasal cavity need be gently anesthetized, if at all. PEAE was performed during the OR turnover period, and rarely introduced even a minor delay. Our subjects found the examination to be less uncomfortable than the one performed by the otolaryngologist during the preoperative visit (often done without anesthetic preparation). We attribute this to our progressive preparation of the nasal cavity as the patient moved from the admitting to the holding areas, and to the OR. No IV premedication (i.e., benzodiazepines) was necessary to perform the PEAE, hence precluding the risk of oversedation in patients with a difficult-to-manage airway.
Skill in the use of AI techniques is critical for the anesthesiologist. When properly applied, AI can be performed efficiently and be comfortable for both the patient and staff. In this study, PEAE not only eliminated several unnecessary AI events, but also identified patients who may have experienced catastrophic outcomes had routine anesthetic induction been chosen. The goal of this study was not to eliminate the use of AI, but rather to validate an evaluation tool that can aid in identifying appropriate candidates for AI.
Among patients who present for intra-airway procedures, standard physical evaluation and the reliance on airway signs and symptoms do not consistently identify all those at risk for airway management failure who present for intra-airway procedures. Endoscopic airway examination in this population reduces the number of unnecessary AI procedures, and may increase patient safety by providing the clinician with superior anatomic information. PEAE can be done with minimal or no schedule delay or patient discomfort, and we believe it increases the clinician's confidence in the airway plan. Because PEAE reduced the number of unneeded AIs and identified high-risk patients who had otherwise been considered for routine anesthesia induction, we believe that it has a place in the evaluation of patients with airway pathology who present for intra-airway surgery. Additionally, PEAE may have a role in the evaluation of patients presenting for surgery remote from the airway, yet harbor chronic airway changes that increase their risk for airway failure (e.g., morbid obesity, obstructive sleep apnea, lingual tonsil hyperplasia, and recent food ingestion).
WR and WS helped design and conduct the study, analyze the data, and write the manuscript. AII helped conduct the study, analyze the data, and write the manuscript. AF helped design the study, analyze the data, and write the manuscript. CS helped design and conduct the study and write the manuscript. All authors have seen the original study data, reviewed the analysis of the data, and approved the final manuscript. WR is the author responsible for archiving the study files.
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© 2011 International Anesthesia Research Society
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