Secondary Logo

Journal Logo

The Association of Malignant Hyperthermia and Unusual Disease: When You’re Hot You’re Hot, or Maybe Not

Davis, Peter J., MD*†; Brandom, Barbara W., MD

doi: 10.1213/ane.0b013e3181b493d4
Editorial: Editorials
Free

From the *Department of Anesthesiology, Children’s Hospital of Pittsburgh, and †Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Accepted for publication June 19, 2009.

Barbara W. Brandom has received research funding from the Malignant Hyperthermia Association of the United States (MHAUS). The North American MH Registry (which is financially supported by MHAUS) may be affected financially by this publication. MHAUS is a not-for-profit organization focused on MH.

Peter J. Davis is a consultant for EISAI Pharmaceuticals, Abbott Laboratories, and Hospira.

Address correspondence and reprint requests to Peter J. Davis, MD, Department of Anesthesiology, Children’s Hospital of Pittsburgh, 45th and Penn, Pittsburgh, PA 15201. Address e-mail to davispj@anes.upmc.edu.

This issue of Anesthesia & Analgesia brings together a collection of papers focused on the prevalence of malignant hyperthermia (MH), the possible association of exertional heat illness with MH, and the association of myotonias, muscular dystrophies, core myopathies, and enzymopathies with MH.1–7 Although these papers have a global perspective, a number of them originate from a 1-day symposium held during the 2008 Society for Pediatric Anesthesia Spring meeting in San Diego.1,3–5 The purpose of this symposium was to discuss the relationship of these disorders to MH in light of what is currently understood with regard to their molecular basis and to identify the clinical challenges that these disorders present to pediatric anesthesiologists.

Because a number of case reports and small series have described patients with these disorders and clinical symptoms of increased temperature, arrhythmias, rhabdomyolysis, and/or hyperkalemia during or after anesthesia, the clinician is confronted with the question of whether there is a true association between these disorders and MH. In view of the relative rarity of these disorders, establishing an association between these disorders and MH becomes difficult.

One of the many challenges of providing anesthesia for pediatric patients is that rare or unusual diseases often remain undiagnosed in infancy and early childhood because they have not produced sufficient physiological impairment or clinical signs and symptoms to merit evaluation. This is especially true in pediatric patients with underlying neuromuscular disorders or enzymopathies undergoing anesthesia for muscle biopsies. In addition, critical incidents during anesthesia occur more frequently in infants and small children compared with older children and adults. Airway and cardiovascular instability frequently occurs on induction of anesthesia in infants and small children. Induction of anesthesia by inhalation of potent anesthetic is a method that can facilitate airway management. To further complicate the anesthetic management, IV access is often a challenge in pediatric patients. The need for venous access can become a major determinant of anesthetic technique.

Usually the pediatric patient who presents for a muscle biopsy has only a tentative diagnosis and therefore the risk of MH in this patient is unknown. Part of the dilemma in assessing MH risk in these patients is understanding the limitations in the MH literature and numerous case reports describing adverse anesthetic events. The “gold standard” for confirming a diagnosis of MH has been the in vitro contracture test. The sensitivity and specificity of the caffeine halothane contracture test has been determined in patients who did not have clinical myopathy. The sensitivity of a diagnostic test is the probability of that test being positive when the patient has the disease. Specificity of the test is the probability of a negative or normal test result when the patient does not have the disease. Any diagnostic test with high sensitivity has a low false negative rate, and tests with a low specificity have a high incidence of false positives. The specificity of the caffeine halothane contracture test is about 80%.8,9 Therefore some patients without MH will have positive contracture tests. Furthermore, the sensitivity and specificity of the caffeine halothane contracture test were determined in patients who did not have other neuromuscular diseases. There is no validation of positive or negative caffeine halothane contracture test cutoff values for MH in patients known to have muscular diseases.

In patients with neuromuscular disease, Adnet et al.12 reported 28 patients with various neuromuscular diseases and no history of MH or family members with MH who underwent contracture testing. In these patients, they noted a large number of fibers that were depolarized, produced less force when stimulated, and had reduced reactivity when exposed to large concentrations of caffeine. Such muscle does not meet the criteria required for interpretation of the caffeine halothane contracture test. The validity of a caffeine halothane contracture test in patients who have neuromuscular disorders and enzymopathies has been debated because the muscles in these patients may be prone to a positive test on exposure to triggering agents.10–12

An alternate to the caffeine halothane contracture test for confirmation of a MH susceptibility (MHS) diagnosis is genetic testing. Unfortunately, genetic testing for MH also has limitations. Genetic testing of MHS has been based on positive caffeine halothane contracture test results. Patients with stronger contracture results than the clinical cutoff for diagnosis of MHS underwent characterization of the ryanodine receptor gene (RYR1), most often in a tiered approach, meaning that the exons in which variants are most commonly found were studied first. Only a small number of patients have undergone complete examination of the entire RYR1 gene. Standard genetic criteria must be met before a variant is identified as causative of MH (see www.emhg.org). At present, more than 300 RYR1 mutations have been documented, and of these, 29 have been formally accepted as causative mutations. Most of the identified variants have not been shown to be causative of MH, because the process of demonstrating in vitro that a RYR1 variant can cause MH requires a significant commitment of resources. Some RYR1 variants do not alter function of the RYR1 calcium channel, and so they do not cause MH. In addition to RYR1, there are two, and possibly more, genetic loci that have been associated with MHS.13,14 Presently there is no clinical genetic test that examines these loci. Thus, failure to identify an MH causative mutation in a genetic screening does not rule out the possibility that a patient could be susceptible to MH.

Anesthetic management of pediatric patients presenting for muscle biopsy presents numerous challenges. In addition to the general risks associated with airway management and cardiovascular instability observed in pediatric anesthesia, some pediatric patients with neuromuscular disease have also been reported to have hyperkalemia, cardiac arrests, rhabdomyolysis, and central nervous system alterations after general anesthesia. Occasionally, these patients are labeled as MH or MHS because of these episodes. But hyperkalemic cardiac arrest is not synonymous with MHS. The number of such cases is so few that a valid assessment of the risk of this event and its possible association with MH is not feasible.

Does the choice of anesthetic alter the risks? How does one balance the challenges of venous access difficulty, the risk of losing airway patency, and cardiovascular instability with the possibility that the underlying disorder could increase susceptibility to MH (Table 1)? Because avoidance of triggering anesthetics (inhaled anesthetics and the depolarizing muscle relaxant succinylcholine) is accepted as standard practice for patients with MH or MHS, the use of regional anesthetics and IV drugs has become the preferred anesthetic management for these patients. However, the sin qua non of IV anesthesia is the presence of a functioning IV catheter. All too often the patients most in need of the IV catheter are those infants whose venous access is difficult. Should infants whose risk of MH is “weak association” be stressed as they undergo multiple percutaneous IV placement attempts? Should these infants undergo awake cutdowns or intraosseous infusions to achieve venous access? It is not surprising that in the review process of these symposium papers significant differences emerged between the expert reviewers as to the choice of anesthetics and anesthetic approaches for patients whose risk was a “weak association.” Some experts maintained that even though some patients do not experience adverse events from exposure to potent inhaled anesthetics, other patients did, and therefore the anesthesiologist should avoid these drugs in all such patients. Other experts maintained that when venous access is a challenge and the risk of MH is weak, brief exposure to inhaled anesthetics during venous cannulation and securing the airway is acceptable practice. If the experts cannot agree, how should less experienced anesthesiologists manage these conundrums?

Table 1

Table 1

One potential solution is to quantify risk. One issue in all of these papers is that each set of authors uses different phrases to describe risk. Descriptions of “weak association,” and “increased more than the general population” only serve to create a wider gray zone. In the case of children with myopathies undergoing anesthesia, they rarely have hyperkalemia, but often do have increased preoperative creatine kinase levels and rhabdomyolysis may worsen postoperatively. Increased creatine phosphokinase, increased potassium, and myoglobinuria are signs associated with MH but do not define MH. Some of these patients will even have positive contracture tests. If they do not have findings of an increased oxygen consumption or a hypermetabolic state, do these patients have more, less, or the same risk level for MH as the patients with disorders labeled “weak association.”

The paper by Benca and Hogan5 gives a thoughtful approach to these disorders where evidence for an association with MH is weak. However, efforts are still needed to better define risk with more complete clinical data, careful analysis of clinical data from children with myopathies and enzymopathies, and further consensus development to define appropriate anesthetic management for these children.

Back to Top | Article Outline

REFERENCES

1. Klingler W, Rueffert H, Lehmann-Horn F, Girard T, Hopkins PM. Core myopathies and risk of malignant hyperthermia. Anesth Analg 2009;109:1167–73
2. Capacchione JF, Muldoon SM. The relationship between exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia. Anesth Analg 2009;109:1065–9
3. Parness J, Bandschapp O, Girard T. The myotonias and susceptibility to malignant hyperthermia. Anesth Analg 2009;109:1054–64
4. Gurnaney H, Brown A, Litman RS. Malignant hyperthermia and muscular dystrophies. Anesth Analg 2009;109:1043–8
5. Benca J, Hogan K. Malignant hyperthermia, coexisting disorders, and enzymopathies: risks and management options. Anesth Analg 2009;109:1049–53
6. Brady JE, Sun LS, Rosenberg H, Li G. Prevalence of malignant hyperthermia due to anesthesia in New York State, 2001 to 2005. Anesth Analg 2009;109:1162–6
7. Hogan KJ, Vladutiu GD. Malignant hyperthermia-like syndrome and carnitine palmitoyltransferase II deficiency with heterozygous R503C mutation. Anesth Analg 2009;109:1070–2
8. Allen GC, Larach MG, Kunselman AR. The sensitivity and specificity of the caffeine-halothane contracture test: a report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS. Anesthesiology 1998;88:579–88
9. Larach MG, Landis JR, Bunn JS, Diaz M. Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. Anesthesiology 1992;76:16–27
10. Heytens L, Martin JJ, Van de Kelft E, Bossaert LL. In vitro contracture tests in patients with various neuromuscular diseases. Br J Anaesth 1992;68:72–5
11. Gronert GA, Fowler W, Cardinet GH III, Grix A Jr, Ellis WG, Schwartz MZ. Absence of malignant hyperthermia contractures in Becker-Duchenne dystrophy at age 2. Muscle Nerve 1992;15:52–6
12. Adnet PJ, Krivosic-Horber M, Krivosic I, Haudecoeur G, Reyford HG, Adamantidis MM, Medahoui H. Viability criterion on muscle bundles used in the in vitro contracture test in patients with neuromuscular diseases. J Anaesth 1994;72:93–7
13. Robinson RL, Curran JL, Ellis FR, Halsall PJ, Hall WJ, Hopkins PM, Iles DE, West SP, Shaw MA. Multiple interacting gene products may influence susceptibility to malignant hyperthermia. Ann Hum Genet 2000;64:307–20
14. Jurkat-Rott K, McCarthy T, Lehmann-Horn F. Genetics and pathogenesis of malignant hyperthermia. Muscle Nerve 2000;23:4–17
© 2009 International Anesthesia Research Society