Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 5th ed.
Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ, eds. Philadelphia: Lippincott Williams & Wilkins, 2006. ISBN 0-7817-4996-4. 1827 pages, $329.00.
For those who have an interest in coagulation and transfusion therapy, the book Hemostasis and Thrombosis: Basic Principles and Clinical Practice has been one of the best resource books available. The new 5th edition continues to provide an in-depth coverage of the basic science of the coagulation system and clinical practice from authors who are the world’s experts in their fields. The number of chapters has grown from 91 in the 4th edition to 123 as a result of the continuing explosion of knowledge in this area, especially from the human genome project. A new cofactor has been discovered, Protein Z, and a new regulatory enzyme that inhibits thrombin-activated fibrinolysis. A new enzyme, ADAMTS13, has been discovered that controls the proteolytic breakdown of von Willebrand factor multimers, and deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. There have been multiple chapters added to the clinical applications section to reflect increased knowledge and increased emphasis on translational medicine.
The strengths of this book are its in-depth coverage of every aspect of the coagulation system both from the basic science aspect and clinical practice. For the casual reader, the review chapters are excellent and provide an outstanding overview. For most anesthesiologist, the clinical practice section chapters would be most useful. Many of the chapters in the clinical practice section provide excellent summaries at end of the chapter. The figures and tables are excellent and appropriate. The final chapters on new thrombolytic and anticoagulant agents were especially intriguing.
There are few weaknesses in the book. They continue to use a very small font, which is difficult to read. The genetic information that is provided is very important, but tends to make one’s eyes glaze over. One of the clinical practice chapters is missing, and it is the readers’ loss as to information that is not presented. Overall, this an excellent book, especially as a reference book for complex coagulation questions.
Gregory A. Nuttall, MD
Department of Anesthesiology