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Friedberg, B.L. MD; Sigl, J.C. PhD

doi: 10.1097/00000539-199902001-00054
Abstracts of Posters; Presented at the International Anesthesia Research Society; 73rd Clinical and Scientific Congress; Los Angeles, CA; March 12-16, 1999: Bispectral

(Friedberg) Corona Del Mar, CA; (Sigl) Aspect Medical Systems, Natick, MA.

Abstract S54

INTRODUCTION: BIS monitoring has been demonstrated to reduce propofol usage in propofol/alfentanil/N2 O technique. [1] The current study investigated the effect of the implementation of routine BIS monitoring on propofol consumption during office-based propofol-ketamine [2] anesthesia.

METHODS: A retrospective analysis of 264 consenting patients receiving propofol-ketamine anesthesia for office-based plastic surgery was performed. Prior to the implementation of routine BIS monitoring (A1050 monitor, Aspect Medical Systems), patients, in the absence of opioids, had propofol (5 mg[center dot]ml-1 via 60 gtts[center dot]ml-1 intravenous set) titrated to standard clinical signs. Subsequently, patients monitored with BIS were titrated to a BIS of >or=to 60 but < 70, with the same initial infusion. After achieving adequate hypnosis, 50 mg of ketamine was administered prior to injection of local anesthetic. Purposeful response to the local injection was treated with additional ketamine (25-50 mg). Cases performed before the implementation of routine BIS monitoring (Pre-BIS, n=135) were compared with those performed after implementation (BIS Monitored, n=129). Propofol usage outliers were defined as those patients requiring > 2,000 mg propofol. The high propofol dose rate group was defined to contain the upper 1/3 of cases by using a threshold of 210 [micro sign] g[center dot]kg-1[center dot]min-1. Statistical comparisons were by t-test and chi-square, with statistical significance defined as p < 0.05.

RESULTS: There were no statistically significant differences between the groups in age, weight, gender or anesthetic duration. Total average propofol consumption decreased by 20%. Ketamine consumption was unchanged. (Table 1)

Table 1

Table 1

The proportion of patients receiving greater than 2000 mg of propofol decreased 48%, from 56/135 in the Pre-BIS group to 28/129 in the BIS Monitored group (p=0.001). The proportion of patients receiving high propofol infusion rates decreased by 39%, from 50/135 in the Pre-BIS group to 29/129 in the BIS Monitored group (p=0.010). (Figure 1)

Figure 1

Figure 1

DISCUSSION: No patients experienced hallucinations in either group but pleasant colorful dreams were reported more often in the BIS group. Statistical analysis confirmed the clinical impression of decreased propofol consumption. The decrease in average propofol consumption of 416 mg translates into a average per patient cost savings of $24.92, using a propofol cost of $12.32/200 mg ampoule and accounting for waste.

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1. Anesth 87:808-15, 1997.
2. Aesth Plast Surg 17:297-300, 1993.
© 1999 International Anesthesia Research Society