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Blood Pressure Coefficient of Variation and Its Association With Cardiac Surgical Outcomes

Jinadasa, Sayuri P. MD*,†; Mueller, Ariel MA*; Prasad, Varesh BS‡,§; Subramaniam, Kathirvel MD, MPH; Heldt, Thomas PhD§,¶; Novack, Victor MD, PhD*; Subramaniam, Balachundhar MD, MPH*

doi: 10.1213/ANE.0000000000003362
Cardiovascular and Thoracic Anesthesiology: Original Clinical Research Report

BACKGROUND: Multiple studies completed in the ambulatory nonsurgical setting show a significant association between short- and long-term blood pressure variability and poor outcomes. However, perioperative blood pressure variability outcomes have not been well studied, especially in the cardiac surgical setting. In this study, we sought to assess whether systolic and mean arterial blood pressure variability were associated with 30-day mortality and in-hospital renal failure in patients undergoing cardiac surgery requiring cardiopulmonary bypass. Furthermore, blood pressure variability has not been evaluated specifically during each phase of surgery, namely in the pre-, intra- and postbypass phases; thus, we aimed also to assess whether outcomes were associated with phase-specific systolic and mean arterial blood pressure variability.

METHODS: All patients undergoing cardiac surgery from January 2008 to June 2014 were enrolled in this retrospective, single-center study. Demographic, intraoperative, and postoperative outcome data were obtained from the institution’s Society of Thoracic Surgery database and Anesthesia Information Management System. Systolic and mean arterial blood pressure variability were assessed using the coefficient of variation (CV). The primary outcomes were 30-day mortality and in-hospital renal failure in relation to the entire duration of a case, while the secondary outcomes assessed phase-specific surgical periods. In an effort to control the family-wise error rate, P values <.0125 were considered significant for the primary outcomes.

RESULTS: Of the 3687 patients analyzed, 2.7% of patients died within 30 days of surgery and 2.8% experienced in-hospital renal failure. After adjusting for significant covariates, we found a statistically significant association between increasing CV for systolic blood pressure (CVSBP) and 30-day mortality and in-hospital renal failure. For every 0.10 increase in CVSBP, there was a 150% increase in the odds of death (odds ratio, 2.50; 95% confidence interval, 1.60–3.92; P < .0001) and there was a 104% increase in odds of experiencing renal failure (odds ratio, 2.04; 95% confidence interval, 1.33–3.14; P = .001). The association with mortality was driven primarily by the prebypass period, because the association between CVSBP and mortality during the prebypass phase was significant (P = .01), and not during the postbypass phase (P = .08). There was no significant association between CV for mean arterial blood pressure and either death or renal failure during any period of surgery, including the bypass phase.

CONCLUSIONS: Increasing systolic blood pressure variability was associated with 30-day mortality and development of renal failure, with surgery phase-specific relationships observed. Further research is required to determine how to prospectively detect blood pressure variability and elucidate opportunities for intervention.

From the Departments of *Anesthesia, Critical Care, and Pain Medicine

General Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

Harvard-Massachusetts Institute of Technology Program in Health Sciences and Technology, Cambridge, Massachusetts

§Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Published ahead of print April 5, 2018.

Accepted for publication February 16, 2018.

Funding: V. Prasad is supported by the US Department of Defense National Defense Science and Engineering Graduate Fellowship. B. Subramaniam is supported by the National Institutes of Health Research Project Grant GM 098406. Statistical and writing support was provided by the Center for Anesthesia Research Excellence at Beth Israel Deaconess Medical Center.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Balachundhar Subramaniam, MD, MPH, Harvard Medical School, Beth Israel Deaconess Medical Center, One Deaconess Rd, C-650, Boston, MA 02215. Address e-mail to

Copyright © 2018 International Anesthesia Research Society
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