Hydroxocobalamin (vitamin B12a) is an emerging treatment for vasoplegic syndrome (VS) associated with cardiopulmonary bypass (CPB). Given its cost and scarcity, an institutional guideline for its use as a rescue treatment in cases of suspected VS was developed. Hemodynamic variables and vasopressor requirements were reviewed for a series of 24 post-CPB patients who received B12a. Favorable changes in hemodynamic parameters and vasopressor requirements were seen after B12a administration although guideline criteria for VS were inconsistently met. These findings support the continued study of B12a in patients with CPB-associated VS.
From the *Department of Anesthesiology & Perioperative Medicine
‡Department of Cardiovascular Surgery, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Accepted for publication June 6, 2018.
The authors declare no conflicts of interest.
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Address correspondence to James A. Nelson, MBBS, Department of Anesthesiology & Perioperative Medicine, Mayo Clinic College of Medicine and Science, 200 First St SW, Rochester, MN 55905. Address e-mail to firstname.lastname@example.org.