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Impact of Anesthetic Regimen on Remote Ischemic Preconditioning in the Rat Heart In Vivo

Behmenburg, Friederike MD*; van Caster, Patrick MD*; Bunte, Sebastian MD*; Brandenburger, Timo MD*; Heinen, André MD, PhD; Hollmann, Markus W. MD, PhD; Huhn, Ragnar MD, PhD*

doi: 10.1213/ANE.0000000000002563
Research Report: PDF Only

Remote ischemic preconditioning (RIPC) seems to be a promising cardioprotective strategy with contradictive clinical data suggesting the anesthetic regimen influencing the favorable impact of RIPC. This study aimed to investigate whether cardio protection by RIPC is abolished by anesthetic regimens. Male Wistar rats were randomized to 6 groups. Anesthesia was either maintained by pentobarbital (Pento) alone or a combination of sevoflurane (Sevo) and remifentanil or propofol (Prop) and remifentanil in combination with and without RIPC. RIPC reduced infarct size in Pento- and Sevo-anesthetized rats (Pento-RIPC: 30% ± 9% versus Pento-control [Con]: 65% ± 6%, P < .001; Sevo-RIPC: 31% ± 6% versus Sevo-Con: 61% ± 8%, P < .001), but RIPC did not initiate cardio protection in Prop-anesthetized animals (Prop-RIPC: 59% ± 6% versus Prop-Con: 59% ± 8%, P = 1.000). Cardio protection by RIPC is abolished by Prop.

From the *Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany; Institute of Cardiovascular Physiology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany; and Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.

Accepted for publication September 12, 2017.

Funding: This work was supported by departmental funding only.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Friederike Behmenburg, MD, Department of Anesthesiology, University Hospital Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany. Address e-mail to

© 2018 International Anesthesia Research Society
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