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Colloids and the Microcirculation

He, Huaiwu PhD,*; Liu, Dawei PhD,*; Ince, Can PhD†‡

doi: 10.1213/ANE.0000000000002620
Research Report: PDF Only

Colloid solutions have been advocated for use in treating hypovolemia due to their expected effect on improving intravascular retention compared with crystalloid solutions. Because the ultimate desired effect of fluid resuscitation is the improvement of microcirculatory perfusion and tissue oxygenation, it is of interest to study the effects of colloids and crystalloids at the level of microcirculation under conditions of shock and fluid resuscitation, and to explore the potential benefits of using colloids in terms of recruiting the microcirculation under conditions of hypovolemia. This article reviews the physiochemical properties of the various types of colloid solutions (eg, gelatin, dextrans, hydroxyethyl starches, and albumin) and the effects that they have under various conditions of hypovolemia in experimental and clinical scenarios.

From the *Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China; Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; and Department of Intensive Care, Erasmus MC, University Hospital Rotterdam, Rotterdam, the Netherlands.

Accepted for publication September 27, 2017.

Funding: H.H. received funding from the China Scholarship Council (No. 201608110082) and the Organization Department of Beijing Municipal Committee (No. 2015000020124G072). C.I. has received honoraria and independent research grants from Fresenius-Kabi, Bad Homburg, Germany, and Baxter HealthCare, Deerfield, IL.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Can Ince, PhD, Department of Intensive Care, Erasmus Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, the Netherlands. Address e-mail to

© 2018 International Anesthesia Research Society
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