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A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects

Sadhasivam, Senthilkumar MD, MPH, MBA, FASA*; Aruldhas, Blessed W. MD*,†,‡; Packiasabapathy, Senthil MD*; Overholser, Brian R. PharmD, FCCP†,§; Zhang, Pengyue PhD; Zang, Yong PhD; Renschler, Janelle S. DVM, PhD*; Fitzgerald, Ryan E. MD; Quinney, Sara K. PharmD, PhD†,#,**

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doi: 10.1213/ANE.0000000000005366

Abstract

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