The effect of intravenous dexamethasone on the regression of sensory and motor block after isobaric bupivacaine spinal anesthesia is unknown. We conducted a prospective, double-blind, randomized controlled trial on 60 patients who received intravenously either placebo (group P) or 8-mg dexamethasone (group D) during the intrathecal injection of 12-mg isobaric bupivacaine 0.5%. Primary outcome was the time from bupivacaine injection to regression of 2 dermatomes in relation to the highest dermatome blocked by the spinal local anesthetic. Time to 2-dermatome regression was 85 minutes (74–96 minutes) in group P versus 87 minutes (76–98 minutes) in group D (P = .79).
From the Département d’anesthésiologie, Centre hospitalier de l’Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada.
Published ahead of print 18 June 2018.
Accepted for publication June 18, 2018.
The authors declare no conflicts of interest.
Clinical Trials identifier: NCT03078062.
Protocol available at: www.clinicaltrials.gov/ct2/show/study/ NCT03078062.
Reprints will not be available from the authors.
Address correspondence to Stephan R. Williams, MD, PhD, Département d’anesthésiologie, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, Montréal, QC H2L 4M1, Canada. Address e-mail to email@example.com.