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Effect of Intravenous Dexamethasone on the Regression of Isobaric Bupivacaine Spinal Anesthesia

A Randomized Controlled Trial

Guay, Juliane, MD; Williams, Stephan R., MD, PhD; Robin, Florian, MD, MSc; Ruel, Monique, RN, CCRP

doi: 10.1213/ANE.0000000000003670
Regional Anesthesia and Acute Pain Medicine: Brief Report

The effect of intravenous dexamethasone on the regression of sensory and motor block after isobaric bupivacaine spinal anesthesia is unknown. We conducted a prospective, double-blind, randomized controlled trial on 60 patients who received intravenously either placebo (group P) or 8-mg dexamethasone (group D) during the intrathecal injection of 12-mg isobaric bupivacaine 0.5%. Primary outcome was the time from bupivacaine injection to regression of 2 dermatomes in relation to the highest dermatome blocked by the spinal local anesthetic. Time to 2-dermatome regression was 85 minutes (74–96 minutes) in group P versus 87 minutes (76–98 minutes) in group D (P = .79).

From the Département d’anesthésiologie, Centre hospitalier de l’Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada.

Published ahead of print 18 June 2018.

Accepted for publication June 18, 2018.

Funding: Internal.

The authors declare no conflicts of interest.

Clinical Trials identifier: NCT03078062.

Protocol available at: NCT03078062.

Reprints will not be available from the authors.

Address correspondence to Stephan R. Williams, MD, PhD, Département d’anesthésiologie, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, Montréal, QC H2L 4M1, Canada. Address e-mail to

© 2019 International Anesthesia Research Society
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