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Intravenously Administered Lidocaine and Magnesium During Thyroid Surgery in Female Patients for Better Quality of Recovery After Anesthesia

Kim, Myoung Hwa, MD, PhD*; Kim, Min Soo, MD, PhD*; Lee, Jae Hoon, MD, PhD*; Kim, Sang Tae, MD, PhD; Lee, Jeong-Rim, MD, PhD*

doi: 10.1213/ANE.0000000000002797
Anesthetic Clinical Pharmacology: Original Clinical Research Report

BACKGROUND: Although systemic lidocaine and magnesium have been widely studied as perioperative analgesic adjuvants, they have been rarely evaluated with respect to recovery quality under the same conditions. We compared the quality of recovery 40 (QoR-40) scores of female patients who received intravenous lidocaine, magnesium, and saline during thyroidectomy to investigate their effects on comprehensive recovery from anesthesia.

METHODS: In this prospective, double-blind trial, 135 female patients scheduled for open thyroidectomy were randomly assigned to the lidocaine group (group L), magnesium group (group M), or control group (group C). Immediately after induction, lidocaine (2 mg/kg for 15 minutes followed by 2 mg/kg/h) was administered in group L and magnesium sulfate (20 mg/kg over 15 minutes followed by 20 mg/kg/h) was administered in group M. Group C received an equivalent volume of saline. The QoR-40 survey was conducted on postoperative days 1 and 2.

RESULTS: The mean global QoR-40 scores on postoperative day 1 were 186.3 (standard deviation, 5.5) in group L, 184.3 (4.7) in group M, and 179.4 (17.8) in group C, and there was a significant difference only between group L and group C (mean difference, 6.9; adjusted P = .018). Among the 5 dimensions of QoR-40, emotional state, physical comfort, and pain were superior in group L compared to group C.

CONCLUSIONS: Lidocaine administered intravenously during anesthesia led to better quality of postoperative recovery measured by QoR-40 compared with the group C. Magnesium was found to be insufficient to induce any significant improvement with the dose used in the present study.

From the *Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

Department of Anesthesiology and Pain Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.

Published ahead of print January 9, 2018.

Accepted for publication November 28, 2017.

Funding: This work was supported by the Yonsei University Research Fund (grant number: 4-2013-0719).

The authors declare no conflicts of interest.

Clinical Trial: NCT02018276 at

Institutional review board: The study protocol was approved by the Institute Research Committee at Severance Hospital, Yonsei University Health System (IRB number: 4-2013-0719). Human Research Protection Center, 50–1 Yonsei-ro, Seodaemun-gu, Seoul 120–752, Republic of Korea. E-mail:

Reprints will not be available from the authors.

Address correspondence to Jeong-Rim Lee, MD, PhD, Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50–1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Address e-mail to

© 2018 International Anesthesia Research Society
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