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Whole Blood for Resuscitation in Adult Civilian Trauma in 2017: A Narrative Review

Pivalizza, Evan G., MD*; Stephens, Christopher T., MD*; Sridhar, Srikanth, MD*; Gumbert, Sam D., MD*; Rossmann, Susan, MD; Bertholf, Marsha F., MD; Bai, Yu, MD; Cotton, Bryan A., MD§

doi: 10.1213/ANE.0000000000003427
Trauma: Narrative Review Article
Continuing Medical Education

After a hiatus of several decades, the concept of cold whole blood (WB) is being reintroduced into acute clinical trauma care in the United States. Initial implementation experience and data grew from military medical applications, followed by more recent development and data acquisition in civilian institutions. Anesthesiologists, especially those who work in acute trauma facilities, are likely to be presented with patients either receiving WB from the emergency department or may have WB as a therapeutic option in massive transfusion situations. In this focused review, we briefly discuss the historical concept of WB and describe the characteristics of WB, including storage, blood group compatibility, and theoretical hemolytic risks. We summarize relevant recent retrospective military and preliminary civilian efficacy as well as safety data related to WB transfusion, and describe our experience with the initial implementation of WB transfusion at our level 1 trauma hospital. Suggestions and collective published experience from other centers as well as ours may be useful to those investigating such a program. The role of WB as a significant therapeutic option in civilian trauma awaits further prospective validation.

From the *Department of Anesthesiology, University of Texas Health McGovern Medical School, Houston, Texas

Executive Staff, Gulf Coast Regional Blood Center, Houston, Texas

Departments of Pathology

§Surgery, University of Texas Health McGovern Medical School, Houston, Texas.

Accepted for publication April 3, 2018.

Funding: Departmental.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Evan G. Pivalizza, MD, Department of Anesthesiology, University of Texas Health McGovern Medical School, Houston, TX. Address e-mail to

© 2018 International Anesthesia Research Society
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