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Validation of a Real-Time Minute-to-Minute Urine Output Monitor and the Feasibility of Its Clinical Use for Patients Undergoing Cardiac Surgery

Chang, Aaron, J., MSE*; Nomura, Yohei, MD; Barodka, Viachaslau, M., MD; Hori, Daijiro, MD; Magruder, Jonathan, T., MD; Katz, Nevin, M., MD; Berkowitz, Dan, E., MD; Hogue, Charles, W., MD§

doi: 10.1213/ANE.0000000000002217
Perioperative Echocardiography and Cardiovascular Education: Brief Report

Acute kidney injury after cardiac surgery is associated with increased morbidity and mortality. Methods for measuring urine output in real time may better ensure renal perfusion perioperatively in contrast to the current standard of care where urine output is visually estimated after empiric epochs of time. In this study, we describe an accurate method for monitoring urine output continuously during cardiopulmonary bypass. This may provide a means for setting patient-specific targets for blood pressure and cardiopulmonary bypass flow as a potential strategy to reduce the risk for acute kidney injury.

Published ahead of print June 22, 2017.

From the *Center for Bioengineering Innovation and Design, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland

§Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Published ahead of print June 22, 2017.

Accepted for publication April 7, 2017.

Funding: Supported by Wallace H. Coulter Foundation Seed Grant, Japan Heart Association/Bayer Yakuhin Grant for Abroad (D.H., Y.N.), and C.W.H. is the principal investigator on a grant from the National Institutes of Health (RO1 092259).

The authors declare no conflicts of interest.

Prototype under development for commercial consideration by A.J.C.

Reprints will not be available from the authors.

Address correspondence to Charles W. Hogue, MD, Department of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron St, Feinberg 5–704, Chicago, IL 60611. Address e-mail to Charles.hogue@northwestern.edu.

© 2017 International Anesthesia Research Society
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