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Effect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: A Randomized Controlled Crossover Pilot Study

Larsen, Mikkel Hjordt Holm MD*; Ekeloef, Sarah MD*; Kokotovic, Dunja MD*; Schou-Pedersen, Anne-Marie PhD; Lykkesfeldt, Jens PhD, DMSc; Gögenür, Ismail MD, DMSc*

doi: 10.1213/ANE.0000000000002357
Basic Science: Brief Report

It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.

From the *Department of Surgery, Center for Surgical Science, Zealand University Hospital, Koege, Denmark; and Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.

Accepted for publication June 8, 2017.

Funding: This study received a grant of $285,943 by The A.P. Møller Foundation for the Advancement of Medical Science.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Mikkel Hjordt Holm Larsen, MD, Department of Surgery, Zealand University Hospital, Lykkebaekvej 1, 4600 Koege, Denmark. Address e-mail to

© 2017 International Anesthesia Research Society
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