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Propofol Infusion and the Incidence of Emesis in Pediatric Outpatient Strabismus Surgery

Weir Patricia M. FRCAnaes; Munro, Hamish M. FRCAnaes; Reynolds, Paul I. MD; Lewis, Ian H. MRCP, FRCAnaes; Wilton, Niall C. T. MRCP, FRCAnaes
Anesthesia & Analgesia: April 1993

A prospective, randomized, double-blind study was conducted to examine the effect of a propofol infusion on the incidence of postoperative emesis in children undergoing Outpatient strabismus surgery. Seventy-eight children, aged 3–12 yr, were allocated randomly to receive either nitrous oxide and halothane or nitrous oxide and a propofol infusion for the maintenance of anesthesia. The overall incidence of vomiting during the first 24 h was 64% in those receiving halothane and 41% in those receiving the propofol infusion; this difference was statistically significant (P < 0.05). In children who received no opioids postoperatively, the incidence of vomiting in the first 24 h was 71% in the halothane group and 24% in the propofol group; this difference was also significant (P = 0.001). We conclude that propofol was effective in reducing the incidence of postoperative emesis in pediatric outpatient strabismus surgery.

Address correspondence and reprint requests to Dr. Paul I. Reynolds, C.S. Mott Childrens Hospital, University of Michigan, Room 4139, Box 0800, Ann Arbor, MI 48109.

© 1993 International Anesthesia Research Society