The effects of lung traction on arterial blood pressure and plasma prostacyclin concentrations were studied in five patients undergoing partial pneumonectomy or lobectomy. After manual traction of a lung segment, mean arterial blood pressure decreased from 77 ± 5 mm Hg (mean ± SEM, before lung traction) to 59 ± 5 mm Hg. The concentrations of 6-keto prostaglandin F1a (a stable breakdown product of prostacyclin) increased significantly from 46 ± 6 pg/mL (mean ± SEM, before thoracotomy) to 593 ± 91 pg/mL. Four of five patients showed facial flushing and palmar erythema. Arterial blood pressure returned to pretraction value, and both the facial flushing and palmar erythema disappeared within 30 min after lung traction. These results suggest that traction of the lung stimulates release and/or production of prostacyclin, which results in facial flushing, palmar erythema, and decrease in arterial blood pressure.
Address correspondence to Dr. Matsumoto, Yamaguchi University, School of Medicine, 1144 Kogushi, Ube, Yamaguchi, 755 Japan.
© 1992 International Anesthesia Research Society