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Murata Kenji MD; Nakagawa, Itsuo MD; Kumeta, Yukihiro MD; Kitahata, Luke M. MD, PhD; Collins, J. G. PhD
Anesthesia & Analgesia: August 1989

The analgesic effectiveness of perispinal clonidine administration prompted us to evaluate clonidine effects on spinal dorsal horn wide dynamic range neurons. Intrathecal clonidine produced a dose-dependent (10 and 30 μg), yohimbine-reversible suppression of noxiously evoked activity in decerebrate, spinal cord-transected cats. In addition, combining ineffective intrathecal doses of morphine (25 μg) and clonidine (5 μg) produced statistically significant, reversible suppression of noxiously evoked activity. The time course of suppression was similar to that observed behaviorally. These results support the role of spinal α2-adrenergic receptors in clonidine analgesia.

Address correspondence to Dr. Collins, Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.

© 1989 International Anesthesia Research Society