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Waymack J. Paul MD; Miskell, Phillip BS; Gonce, Sara BS
Anesthesia & Analgesia: August 1989

Anesthesia and blood transfusions have been demonstrated to impair immune function. The present study evaluated whether these impairments led to increased susceptibility to infectious complications in two animal models. Both transfusions and anesthesia (methoxyflurane) were found to increase susceptibility to peritoneal Escherichia coli infections. This susceptibility increased with time after the transfusions but decreased with time after anesthesia. Neither transfusions nor anesthesia altered susceptibility to an intravenous Escherichia coli challenge in rats.

Address correspondence to Dr. J. Paul Waymack, Chief, Surgical Study Branch, U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234–5012.

© 1989 International Anesthesia Research Society