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Sinatra Raymond S. MD PhD; Philip, Beverly K. MD; Naulty, J. Stephen MD; Ostheimer, Gerard W. MD
Anesthesia & Analgesia: December 1985

Magnesium sulfate (MgSO4) is widely utilized in the treatment of preeclamptic hyperreflexia. Such therapy has important anesthetic implications because increases in plasma magnesium potentiate the activity of both depolarizing and nondepolarizing neuromuscular blocking agents (1). In a recent animal study, Tran et al. (2) reported significant interaction between MgSO4 and vecuronium, a nondepolarizing muscle relaxant of intermediate duration. Although vecuronium dose requirements in patients treated with MgSO4 have yet to be determined, we present a case in which marked prolongation of neuromuscular blockade occurred after use of vecuronium in a patient being treated with MgSO4.

Address correspondence to Dr. Sinatra, Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.

© 1985 International Anesthesia Research Society