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Mixtures of Local Anesthetics: Bupivacaine-Chloroprocaine

Galindo Anibal MD PhD; Witcher, Terry BS
Anesthesia & Analgesia: September 1980

Experiments were performed in a rat sciatic nerve preparation to determine the characteristics of nerve blocks produced by a combination of commercially available solutions of bupivacaine and chloroprocaine. A mixture of equal parts or commercially available chloroprocaine 2% and bupivacaine 0.5% resulted in a nerve blockade with characteristics of a chloroprocaine block. Changing the pH value of this mixture from 3.60 to 5.56 changed these characteristics to a blockade resembling that produced by bupivacaine. It is concluded that the nerve blockades obtained by mixing commercially available solutions of local anesthetics are unpredictable and may depend on a number of factors which include not only the types of drugs but the pH of the mixture.

Partially supported by grants from the American Heart Association, Florida Affiliated, West Florida Chapter and from Abbott Universal Ltd (Latin America).

© 1980 International Anesthesia Research Society