In 12 patients undergoing saphenous vein coronary artery bypass operations cardiovascular hemodynamics were studied in the awake state (control) and during anesthesia with isoflurane (inspired concentration, 1.24%, 7 patients) or with halothane (inspired concentration, 0.77%, 5 patients). Isoflurane anesthesia was accompanied by decreases of 19% in the cardiac in- dex (), 19% in mean arterial pressure
and 16% in heart rate (HR). Only the change in
was statistically significant. Halothane anesthesia was accompanied by decreases in (28%)
(22%), and HR (10%). The changes in and
were significant. HR did not change significantly following the induction of anesthesia with either agent. The decrease in
was similar with both agents, and, in this regard, neither agent was clearly superior for patients with occlusive coronary artery disease.
This study was supported in part by a grant-in-aid from Ohio Medical Products, a division of Airco, Inc.
© 1976 International Anesthesia Research Society