New Antibody/TechniquesD2-40 Immunohistochemistry—So Far!Kalof, Alexandra N. MD; Cooper, Kumarasen MBChB, DPhil, FRCPathAuthor Information Department of Pathology, University of Vermont/Fletcher Allen Health Care, Burlington, VT All figures can be viewed online in color at http://www.anatomicpathology.com. Reprints: Alexandra N. Kalof, MD, Department of Pathology, University of Vermont/Fletcher Allen Health Care, Burlington, VT 05401 (e-mail: [email protected]). Advances in Anatomic Pathology: January 2009 - Volume 16 - Issue 1 - p 62-64 doi: 10.1097/PAP.0b013e3181915e94 Buy Metrics Abstract D2-40 is a commercially available monoclonal antibody directed against human podoplanin, a transmembrane mucoprotein that is expressed in lymphatic endothelial cells. Since its introduction, D2-40 immunoexpression has been described in a variety of lymphovascular neoplasms including lymphangioma, Kaposi sarcoma, and hemangioendothelioma, as well as nonvascular neoplasms such as epithelioid mesothelioma, seminoma, and hemangioblastoma. More recently, D2-40 immunoexpression has been reported in primary adrenal cortical tumors, schwannomas, and adnexal tumors of the skin. This brief review provides an update on the everexpanding proposed applications of D2-40 immunohistochemistry in surgical pathology. © 2009 Lippincott Williams & Wilkins, Inc.