New Antibody/TechniquesPodoplanin: A Novel Diagnostic Immunohistochemical MarkerOrdóñez, Nelson G. MD Author Information University of Texas, Anderson Cancer Center, Houston, TX Reprints: Dr Nelson G. Ordóñez, MD, Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 (e-mail: [email protected]) Received for publication March 2, 2006; accepted March 2, 2006 Advances in Anatomic Pathology 13(2):p 83-88, March 2006. | DOI: 10.1097/01.pap.0000213007.48479.94 Buy Metrics Abstract Podoplanin is a transmembrane mucoprotein recognized by the recently commercially available D2-40 monoclonal antibody. Recent investigations have shown that podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be strongly expressed in seminomas, epithelioid mesotheliomas, and hemangioblastomas, and immunostaining for this marker can assist in the diagnosis of these tumors. This article reviews the current information on the applications of podoplanin immunostaining in surgical pathology. Copyright © 2006 Wolters Kluwer Health, Inc. All rights reserved.