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The Evolving Molecular Genetics of Low-grade Glioma: Erratum

Advances In Anatomic Pathology: May 2015 - Volume 22 - Issue 3 - p 226
doi: 10.1097/PAP.0000000000000071

In the article “The Evolving Molecular Genetics of Low-grade Glioma” in the March 2015 issue of Advances in Anatomic Pathology on pages 94–101, the figure legends were mistakenly switched.

The legends should have been listed as follows:

FIGURE 1. FGFR1 and BRAF alterations in pediatric low-grade glioma (LGG) converge on the mitogen-activated protein (MAP) kinase pathway. Alterations in FGFR1 result in constitutive activation of the receptor resulting in activation of the MAP kinase pathway. A subset of pediatric LGG also shows mutations in the receptor tyrosine kinase NTRK2. Rare mutations involve other members of this pathway including RAS, NF1 (negative regulator of RAS), and PTPN11, a tyrosine phosphatase adapter protein. BRAF V600E mutations and the BRAF-KIAA1549 fusion (other rare fusions not illustrated) also result in constitutive kinase activity and aberrant MAP kinase activation. Please see this image in color online.

FIGURE 2. IDH 1/2, ATRX, and TERT promoter mutations and 1p/19q codeletion in adult low-grade glioma (LGG). IDH 1/2 mutations are thought to be an early event in adult LGG pathogenesis in a common precursor cell. Mutations in IDH1 (cytoplasmic) and IDH2 (mitochondrial) result in the generation of the oncometabolite 2-hydroxyglutarate (2HG). 2HG is thought to inhibit aketoglutarate-dependent demethylases resulting in histone and DNA-CpG island methylation (G-CIMP phenotype). Mutations in ATRX are seen in astrocytic tumors. ATRX is a helicase belonging to the SWItch/Sucrose NonFermentable family involved in H3.3 deposition (along with its partner DAXX). Its deficiency induces alternative lengthening of telomeres. 1p/19q codeletion is seen in oligodendrogliomas. CIC and FUBP1 alterations are associated with 1p/19q codeletion in a variable percentage of oligodendrogliomas. TERT promoter mutations are also noted in oligodendrogliomas and are thought to be important for telomere maintenance. Please see this image in color online.

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1. Venneti S, Huse JT. The Evolving Molecular Genetics of Low-grade Glioma. Adv Anat Pathol. 2015;22:94–101.
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