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HPV-related Squamous Neoplasia of the Lower Anogenital Tract: An Update and Review of Recent Guidelines Erratum

Advances In Anatomic Pathology: March 2015 - Volume 22 - Issue 2 - p 147
doi: 10.1097/01.pap.0000460830.58578.14
Erratum
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In the article “HPV-related Squamous Neoplasia of the Lower Anogenital Tract: An Update and Review of Recent Guidelines” in the September 2014 issue of Advances in Anatomic Pathology on pages 341–358, an erroneous statement appears in the RESPONSE TO LAST section.

On page 351, the error is in the first few sentences of the “Studies on p16” sub-heading. Currently it reads as follows:

A few groups have examined the implications of the LAST recommendations on the use of p16. One study from China with a large number of patients found that 42.7% of lesions diagnosed as CIN 2 were p16 positive, a result that suggests that the new recommendations would result in over half of CIN 2s being downgraded.89 However, this study also found that only 75.5% of lesions diagnosed as CIN 3 were p16 positive, an unusual finding given that prior studies have found close to 100% of CIN 3s to have diffuse strong p16 expression.

The corrected paragraph should read as follows:

A few groups have examined the implications of the LAST recommendations on the use of p16. One study from China with a large number of patients found that 75.5% of lesions diagnosed as CIN 2 were p16 positive, a result that suggests that the new recommendations would result in one quarter of CIN 2s being downgraded. However, this study also found that only 79.6% of lesions diagnosed as CIN 3 were p16 positive, an unusual finding given that prior studies have found close to 100% of CIN 3s to have diffuse strong p16 expression.

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REFERENCE

1. Maniar KP, Nayar R. HPV-related squamous neoplasia of the lower anogenital tract: an update and review of recent guidelines. Adv Anat Pathol. 2014;21:341–358.
© 2015 by Lippincott Williams & Wilkins.