Review ArticlesSmall Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization UpdatesSung, Simon MD*; Heymann, Jonas J. MD†; Politis, Michelle Garlin MD*; Baine, Marina K. MD, PhD‡; Rekhtman, Natasha MD, PhD‡; Saqi, Anjali MD, MBA* Author Information *Department of Pathology & Cell Biology, Columbia University Irving Medical Center †Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital-Weill Cornell Medical College ‡Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY The authors have no funding or conflicts of interest to disclose. All figures can be viewed online in color at www.anatomicpathology.com Reprints: Anjali Saqi, MD, MBA, Columbia University Medical Center, Department of Pathology & Cell Biology, 630 W. 168th St, New York, NY 10032 (e-mail: [email protected]). Advances In Anatomic Pathology 29(6):p 329-336, November 2022. | DOI: 10.1097/PAP.0000000000000360 Buy Metrics Abstract Pulmonary neuroendocrine neoplasms comprise ~20% of all lung tumors. Typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma represent the 4 major distinct subtypes recognized on resections. This review provides a brief overview of the cytomorphologic features and the 2021 World Health Organization classification of these tumor types on small biopsy and cytology specimens. Also discussed are the role of immunohistochemistry in the diagnosis and molecular signatures of pulmonary neuroendocrine tumors. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.