Review ArticlesApproach to Fine Needle Aspiration of Giant Cell-rich Tumors of Soft TissueRottmann, Douglas MD; Pantanowitz, Liron MD, MHA Author Information Department of Pathology, University of Michigan, Ann Arbor, MI The authors have no funding or conflicts of interest to disclose. Reprints: Douglas Rottmann, MD, Department of Pathology, University of Michigan, 2800 Plymouth Rd, NCRC Bldg 35, Ann Arbor, MI 48109 (e-mail: [email protected]). All figures can be viewed online in color at www.anatomicpathology.com. Advances In Anatomic Pathology: November 2022 - Volume 29 - Issue 6 - p 401-411 doi: 10.1097/PAP.0000000000000359 Buy Metrics Abstract Giant cells may be found in a wide variety of reactive and neoplastic soft tissue lesions. Because of their distinct histomorphology, they often stand out in procured samples such as fine needle aspirates. The giant cells themselves may be benign or neoplastic. However, the presence, type, and quantity of giant cells are usually not specific and in some cases can even be misleading when making a diagnosis. The aim of this review is to guide the practicing cytopathologist in narrowing their differential diagnosis when encountering one of these challenging giant cell-rich lesions of the soft tissue. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.