Review ArticlesApproach to FNA of Pancreatic CystsJhala, Nirag MD*; Jhala, Darshana MD, BMus†,‡ Author Information *Department of Pathology and Laboratory Medicine, Temple University Hospital, Lewis Katz School of Medicine at Temple University †Department of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania ‡Pathology and Laboratory Services, CMC Philadelphia VA Medical Center, Philadelphia, PA The authors have no funding or conflicts of interest to disclose. Reprints: Nirag Jhala, MD, Department of Pathology and Laboratory Medicine, OPB 249, Temple University Hospital, 3901 North Broad Street, Philadelphia, PA 19140 (e-mail: [email protected]). Advances In Anatomic Pathology 29(6):p 349-357, November 2022. | DOI: 10.1097/PAP.0000000000000378 Buy Metrics Abstract Pancreatic cysts are increasingly detected on imaging studies. Accurate determination of the type of cyst is important to provide appropriate care for patients. It is also very clear that not one single modality can provide adequate diagnostic information for pancreatic cysts. A multimodal approach to the diagnosis of pancreatic cyst is the key. This review will highlight how to approach to fine-needle aspiration of pancreatic cysts. The review will also highlight salient features of common neoplastic pancreatic cysts along with the use of ancillary testing which includes biochemical testing, commonly utilized molecular tests, and/or immunohistochemical tests to provide an accurate diagnosis. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.