Review ArticlesApproach to FNA of Myxoid Soft Tissue TumorsSatturwar, Swati MD*; Wakely, Paul E. Jr MD*; Pantanowitz, Liron MD, MHA† Author Information *Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH †Department of Pathology, University of Michigan, Ann Arbor, MI The authors have no funding or conflicts of interest to disclose. Reprints: Liron Pantanowitz, MD, MHA, Department of Pathology, University of Michigan, NCRC Bldg 35, 2800 Plymouth Road, Ann Arbor, MI 48109-2800 (e-mail: [email protected]). All figures can be viewed online in color at www.anatomicpathology.com. Advances In Anatomic Pathology: November 2022 - Volume 29 - Issue 6 - p 380-388 doi: 10.1097/PAP.0000000000000354 Buy Metrics Abstract Myxoid tumors of the soft tissue encompass a group of heterogenous tumors that are characterized by the presence of abundant extracellular myxoid or chondromyxoid matrix material. Fine needle aspiration (FNA) is variably used for diagnosing primary, recurrent, and metastatic myxoid soft tissue tumors. The spectrum of myxoid soft tissue tumors encountered in practice ranges from benign lesions such as simple ganglion cysts to high-grade malignant sarcomas such as myxofibrosarcoma. These myxoid tumors have clinical, cytologic, and histologic overlap. Therefore, making an accurate diagnosis by FNA alone is challenging. Despite this challenge, using a systematic cytomorphologic approach and ancillary studies, an accurate diagnosis is feasible in the majority of cases. This article provides a systematic approach to diagnosing myxoid soft tissue tumors by FNA along with a review of the literature. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.