Oral Epithelial Dysplasia: A Review of Diagnostic Criteria for Anatomic Pathologists : Advances in Anatomic Pathology

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Oral Epithelial Dysplasia: A Review of Diagnostic Criteria for Anatomic Pathologists

Cheung, Veronica K.Y. FRCPA*,†; Hulme, Katherine MBChB*; Schifter, Mark FRACDS‡,§,∥; Palme, Carsten FRACS†,∥; Low, Tsu-Hui (Hubert) FRACS†,∥,¶; Clark, Jonathan FRACS†,∥,#; Gupta, Ruta MD, FRCPA, DMedSci*,†

Author Information

*Department of Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital

†Faculty of Medicine and Health, Sydney Medical School

‡Westmead Centre for Oral Health, Westmead Hospital, a Teaching Hospital of the Sydney Dental School, Faculty of Medicine and Health, University of Sydney

§The Skin Hospital, Darlinghurst (Sydney)

∥Sydney Head and Neck Cancer Institute, Chris O’Brien Lifehouse

¶Department of Otolaryngology – Head & Neck Surgery, Faculty of Medicine and Health Sciences, Macquarie University

#Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia

The authors have no funding or conflicts of interest to disclose.

All figures can be viewed online in color at www.anatomicpathology.com.

Reprints: Ruta Gupta, MD, FRCPA, DMedSci, Department of Tissue Pathology and Diagnostic Oncology, Building 94, Royal Prince Alfred Hospital, John Hopkins Drive, Camperdown, NSW 2050, Australia (e-mail: [email protected]).

Advances In Anatomic Pathology 29(4):p 227-240, July 2022. | DOI: 10.1097/PAP.0000000000000343

Abstract

Oral epithelial dysplasia (OED) represents a spectrum of histologic changes in the oral cavity mucosa that has the potential to transform into oral squamous cell carcinoma. Predicting the risk of malignant transformation is predominantly based on clinicopathologic correlation, histologic examination and grading. OED often poses a diagnostic challenge, primarily due to its histologic mimics and a large number of terminologies used in the literature. The grading system for OED is also fraught with significant interobserver variability. This review summarizes the essential clinical and histopathologic features of OED and its mimics. Practical preanalytical, analytical, and postanalytical considerations for anatomic pathologists are discussed to improve the diagnostic accuracy and increase the reproducibility in the grading of OED.

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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