Review ArticlesCarcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic ConsiderationsArafah, Maria MD*; Rashid, Sameera MD†; Tulbah, Asma MD, FRCPA‡; Akhtar, Mohammed MD, FCAP, FRCPath, FRCPA†Author Information *Department of Pathology, King Saud University ‡Department of Pathology and Laboratory Medicine, King Faisal Hospital and Research Center, Riyadh, Saudi Arabia †Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar The authors have no funding or conflicts of interest to disclose. Reprints: Maria Arafah, MD, Department of Pathology, King Saud University, Riyadh 11421, Saudi Arabia (e-mail: [email protected]). All figures can be viewed online in color at www.anatomicpathology.com. Advances In Anatomic Pathology: May 2021 - Volume 28 - Issue 3 - p 150-170 doi: 10.1097/PAP.0000000000000300 Buy Metrics Abstract Most cervical carcinomas and their related lesions are attributed to an infection by human papillomavirus (HPV). The infection usually starts in the basal cells at the squamocolumnar junction. It causes cell proliferation and maturation abnormalities along with nuclear abnormalities resulting in low-grade squamous intraepithelial lesions. An overwhelming majority of these lesions spontaneously disappear, and the infection is cleared. In a small subset of high-risk HPV infection cases, the lesions may persist and progress to high-grade squamous intraepithelial lesions. These are associated with the incorporation of the viral genome into the human genome. Some of the high-grade squamous intraepithelial lesions, over several years, progress to invasive carcinoma. Carcinomas of the cervix are usually squamous cell carcinomas (SCCs), but 20% to 25% of the cases may manifest as adenocarcinomas. Similar to SCC, adenocarcinomas may initially manifest as adenocarcinomas in situ and may progress to invasive carcinomas after a variable period of time. In the recently published World Health Organization classification of female genital tumors, SCCs, and adenocarcinomas of the cervix are divided into HPV-associated and HPV-independent tumors. This review draws on the latest terminology and the several morphologic subtypes recognized for each category. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.